Patents by Inventor Pu-Ting Xu

Pu-Ting Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Creation of human apolipoprotein E isoform specific transgenic mice in apolipoprotein deficient "knockout" mice
    Patent number: 5767337
    Abstract: A transgenic mouse that expresses the human Apo E isoforms Apo E2, Apo E3 or Apo E4 but is essentially incapable of expressing endogenous Apo E. Additionally, mice that express more than one of these isoforms are produced by selectively breeding the transgenic mice expressing the different Apo E isoforms disclosed herein. Thus, the present invention allows, among other things, the study of the effects of different combinations of human Apo E isoform expression on normal brain biology, development, function, aging and injury.
    Type: Grant
    Filed: July 31, 1995
    Date of Patent: June 16, 1998
    Assignee: Duke University
    Inventors: Allen D. Roses, John R. Gilbert, Pu-Ting Xu, Donald E. Schmechel