Patents by Inventor Pu Zhou

Pu Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10351817
    Abstract: This invention provides an Amycolatopsis sp. strain (zhp06), and a method of using the whole cell preparation of the strain for vanillin production. The strain was deposited in China Center for Type Culture Collection on Jul. 26, 2011 with the number of CCTCC NO: M 2011265. Under high concentrations of ferulic acid substrate, the vanillin production by this method can reach more than 10 g/L. The molar conversion rate of ferulic acid is more than 50% and the purity of vanillin is from 80% to 95%. The advantage of this invention includes: repeated use of biocatalyst cells, mild biotransformation condition, low environmental pollution, short production cycle, high product purity and simple purification procedure. It has a great potential for industrial applications.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: July 16, 2019
    Assignee: BGN TECH LLC
    Inventors: Pu Zheng, Hui Li, Xinglin Wang, Jianhai Zhou, Shibiao Chu
  • Patent number: 10327896
    Abstract: An expandable introducer sheath for passage of implant delivery catheters, such as catheters for delivery of prosthetic heart valves. The expandable sheath balances the amounts, shapes and positions of various stiff and elastic structures in the sheath to selectively program the expandability and buckling stiffness of the sheath. The expandable sheath can include, for example, an expandable tubular layer that includes alternating stiff and elastic wall portions of a single radial thickness. The combination of stiff and elastic wall portions allow for torque and push strength to advance the expandable sheath while at the same time accommodating temporary expansion. The expandable sheath can also be reinforced with a tubular layer of braided fibers or a stent structure for additional strength. Other embodiments include selective use of slots or gaps at the distal end of a stiff wall portion to enhance expandability and distribute strain.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: June 25, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Pu Zhou, Yong Gao, Erik Bulman, Baigui Bian, Yidong M. Zhu, David D. Williams
  • Patent number: 10258770
    Abstract: A recanalization catheter for facilitating re-entry into a lumen of a blood vessel from a subintimal space. The catheter includes an inflatable balloon mounted on a distal end region of the catheter shaft of the catheter. The catheter shaft includes a guidewire lumen having a distal opening and a lateral opening in a distal region of the catheter shaft proximal of the distal opening, and an inflation lumen in fluid communication with the balloon. The balloon is configured to be inflated in the subintimal space to a first inflation state at inflation pressures below a threshold inflation pressure to orient the lateral opening toward the lumen of the blood vessel, and inflated to a second inflation state at inflation pressures above the threshold inflation pressure. The catheter includes means for retaining the balloon in the first inflation state at pressures below the threshold inflation pressure.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: April 16, 2019
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Huisun Wang, Pu Zhou, Benjamin Gundale, Daniel Horn, John Chen
  • Publication number: 20190059668
    Abstract: A vacuum cleaner can include an upright section, a surface cleaning head coupled to the upright section, and at least one wheel coupled to the surface cleaning head. The at least one wheel can include a hub, a rim, and an absorber. The absorber can extend between the hub and the rim. The absorber can be configured to deform before the rim experiences substantial deformation. A deformation limiter can be provided that is configured to limit the deformation in the absorber.
    Type: Application
    Filed: August 30, 2018
    Publication date: February 28, 2019
    Inventors: Jason B. THORNE, Pu ZHOU, Ming YAO, Gordon HOWES
  • Publication number: 20190046315
    Abstract: An implantable prosthetic valve assembly, according to one embodiment, comprises a frame assembly including a plurality of struts and a prosthetic valve secured inside the frame assembly by sutures. The sutures are inward of the outermost surface of an outer periphery of the frame assembly. In certain embodiments the struts contain recesses in which sutures can be disposed. In other embodiments, the struts can have holes through them which the sutures pass through. The implantable prosthetic valve assembly can also be collapsed within a catheter such that an outermost surface of a periphery of the frame assembly touches the catheter but the sutures are spaced apart from the catheter or are flush with the outer surface of the frame.
    Type: Application
    Filed: August 10, 2018
    Publication date: February 14, 2019
    Inventors: Yong Gao, Pu Zhou, Tianwen Zhao, Jeffrey Wu
  • Publication number: 20190030299
    Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.
    Type: Application
    Filed: October 2, 2018
    Publication date: January 31, 2019
    Inventors: Pu Zhou, Erik Bulman, Timothy A. Geiser, Michael G. Valdez, Yidong M. Zhu, Baigui Bian, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana K. Gowdar, Yong Gao, David D. Williams
  • Publication number: 20190030296
    Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.
    Type: Application
    Filed: October 2, 2018
    Publication date: January 31, 2019
    Inventors: Pu Zhou, Erik Bulman, Timothy A. Geiser, Michael G. Valdez, Yidong M. Zhu, Baigui Bian, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana K. Gowdar, Yong Gao, David D. Williams
  • Publication number: 20190030295
    Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.
    Type: Application
    Filed: October 2, 2018
    Publication date: January 31, 2019
    Inventors: Pu Zhou, Erik Bulman, Timothy A. Geiser, Michael G. Valdez, Yidong M. Zhu, Baigui Bian, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana K. Gowdar, Yong Gao, David D. Williams
  • Publication number: 20190030297
    Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.
    Type: Application
    Filed: October 2, 2018
    Publication date: January 31, 2019
    Inventors: Pu Zhou, Erik Bulman, Timothy A. Geiser, Michael G. Valdez, Yidong M. Zhu, Baigui Bian, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana K. Gowdar, Yong Gao, David D. Williams
  • Publication number: 20190029820
    Abstract: An expandable introducer sheath for passage of implant delivery catheters, such as catheters for delivery of prosthetic heart valves. The expandable sheath balances the amounts, shapes and positions of various stiff and elastic structures in the sheath to selectively program the expandability and buckling stiffness of the sheath. The expandable sheath can include, for example, an expandable tubular layer that includes alternating stiff and elastic wall portions of a single radial thickness. The combination of stiff and elastic wall portions allow for torque and push strength to advance the expandable sheath while at the same time accommodating temporary expansion. The expandable sheath can also be reinforced with a tubular layer of braided fibers or a stent structure for additional strength. Other embodiments include selective use of slots or gaps at the distal end of a stiff wall portion to enhance expandability and distribute strain.
    Type: Application
    Filed: October 2, 2018
    Publication date: January 31, 2019
    Inventors: Pu ZHOU, Yong GAO, Erik BULMAN, Baigui BIAN, Yidong M. ZHU, David D. WILLIAMS, Timothy A. GEISER, Michael G. VALDEZ, Sonny TRAN, Richard D. WHITE, Thanh Huy LE, Tung T. LE, Alpana K. GOWDAR
  • Publication number: 20190029409
    Abstract: A cleaning roller is mountable to a cleaning robot. The cleaning roller includes a sheath comprising a shell, an outer diameter of the shell tapering from a first end portion of the sheath and a second end portion of the sheath toward a center of the roller. The cleaning roller further includes a core including a central portion interlocked with the sheath to rotationally couple the core to the sheath and inhibit relative translation of the sheath and the core along an axis of rotation. An inner surface of the sheath and an outer surface of the core define an air gap therebetween, the air gap extending from the central portion of the core longitudinally along the axis of rotation toward the first end portion or the second end portion.
    Type: Application
    Filed: July 25, 2017
    Publication date: January 31, 2019
    Inventors: Matthew Blouin, Pierre Paul Richard Souloumiac, Pu Zhou
  • Publication number: 20190030298
    Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.
    Type: Application
    Filed: October 2, 2018
    Publication date: January 31, 2019
    Inventors: Pu Zhou, Erik Bulman, Timothy A. Geiser, Michael G. Valdez, Yidong M. Zhu, Baigui Bian, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana K. Gowdar, Yong Gao, David D. Williams
  • Publication number: 20180326186
    Abstract: A medical device assembly may include an elongated tubular membrane having a wall defining a lumen extending through the membrane from a proximal end to a distal end, the lumen having a first inner diameter, and a percutaneous medical device having a maximum outer diameter greater than the first inner diameter, wherein the membrane is configured to permit the medical device to pass through the lumen, and wherein the membrane includes a plurality of longitudinally-oriented channels recessed along an inner surface of the wall. A medical device delivery sheath may include a tubular first layer of polymeric material formed into a wavy cross-section having a plurality of lobes and a plurality of valleys, wherein the first layer of material is resiliently expandable in a radial direction from a relaxed configuration to an expanded configuration, and wherein the first layer of material is substantially non-expandable in an axial direction.
    Type: Application
    Filed: July 5, 2018
    Publication date: November 15, 2018
    Applicant: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Pu Zhou, Huisun Wang
  • Patent number: 10117659
    Abstract: A recanalization catheter for facilitating re-entry into a lumen of a blood vessel from a subintimal space. The recanalization catheter includes first and second mechanically actuatable wings positioned at a distal region of the elongate shaft of the catheter that are actuatable between a retracted position and an expanded position. In the retracted position the mechanically actuatable wings are positioned in first and second elongate channels defined in the elongate shaft, and in the expanded position the mechanically actuatable wings extend outward from the first and second elongate channels. The actuatable wings extend in an arcuate path away from the elongate shaft in the expanded position to be positionable in a circumferential orientation within a subintimal space formed in a vessel wall to automatically orient a lateral port of the elongate shaft toward the true lumen.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: November 6, 2018
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Pu Zhou, Huisun Wang
  • Publication number: 20180256858
    Abstract: An expandable delivery sheath includes an elastic outer tubular layer and an inner tubular layer. The inner tubular layer include a thick wall portion integrally connected to a thin wall portion. The thin wall portion can include longitudinal reinforcing members/rods that facilitate unfolding during the passage of the implant, thus decreasing the push force and increasing the consistency of the push force. The inner tubular layer can have a non-expanded or folded condition wherein the thin wall portion folds onto an outer surface of the thick wall portion under urging of the elastic outer tubular layer. When an implant passes therethrough, the outer tubular layer stretches and the inner tubular layer unfolds into an expanded lumen diameter. Once the implant passes, the outer tubular layer again urges the inner tubular layer into the non-expanded condition with the sheath reassuming its smaller profile.
    Type: Application
    Filed: March 7, 2018
    Publication date: September 13, 2018
    Inventors: Pu Zhou, Erik Bulman, Baigui Bian
  • Publication number: 20180207395
    Abstract: Disclosed herein are expandable introducer sheaths and methods of making and using the same. The sheaths minimize trauma to a patient's vasculature by allowing for temporary expansion of a portion of the sheath to accommodate passage of a delivery system for a cardiovascular device, then return to a non-expanded state after the passage of the device. The sheath includes an elongated annular member having longitudinally extending channels that facilitate the sheath's temporary expansion. The channels are positioned in such a way that, upon expansion, they enable the movement of protruding contact surfaces toward the inner and outer surfaces of the annular member, reducing friction between the surface and the passing device. Some embodiments of the expandable sheath include an elastic outer layer that pushes the protruding contact surfaces back towards their original positions after the passage of the device.
    Type: Application
    Filed: January 19, 2018
    Publication date: July 26, 2018
    Inventors: Erik Bulman, Pu Zhou
  • Publication number: 20180071500
    Abstract: Inflatable devices are disclosed including a surface which has a network of polymer chains and is configured to be inflatable into a therapeutically or diagnostically useful shape, and at least one ultrashort laser pulse-formed modification in the surface. The network can, for example, include a network morphology that is substantially unchanged by modification with the ultrashort pulse laser. Ultrashort laser pulses can be laser pulses equal to or less than 1000 picoseconds in duration. Advantageously, the etching process uses a relatively low-heat laser to avoid significant heating of surrounding polymers while modifying the surface (and other structures) of the device. The process is configured so that the polymer chain morphology adjacent the modification is substantially unaffected by the low-heat laser. The resulting inflatable device has customized surface features while still retaining substantially homogenous polymer network morphology.
    Type: Application
    Filed: November 16, 2017
    Publication date: March 15, 2018
    Inventors: Pu Zhou, Bin Tian, Yidong M. Zhu
  • Publication number: 20180064524
    Abstract: A catheter assembly comprises a catheter having a distal end and a longitudinal axis, a stent disposed about the distal end of the catheter, and a stent protector. The stent protector has a stent covering portion disposed about the stent and a catheter engagement portion that removably engages the stent protector to the catheter assembly. The stent covering portion is disposed about the stent without substantially engaging the stent.
    Type: Application
    Filed: November 14, 2017
    Publication date: March 8, 2018
    Applicant: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: JOEL WASDYKE, MICHAEL D. JOHNSON, SHAWN SORENSON, RAYMOND ADNEY, RAM PERIAKARUPPAN, MATT HEIDNER, SEAN MCNULTY, PU ZHOU
  • Patent number: 9889007
    Abstract: A heart valve delivery system includes a low-profile catheter having an outer sheath, the outer sheath having therein a stent and a replacement heart valve. In an unemployed configuration, the stent is located distally to the replacement heart valve. Upon deployment, however, the stent and replacement heart valve are expanded and the replacement heart valve is situated within the stent.
    Type: Grant
    Filed: January 18, 2016
    Date of Patent: February 13, 2018
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Pu Zhou, Huisun Wang, James Q. Feng
  • Patent number: 9814557
    Abstract: A catheter assembly comprises a catheter having a distal end and a longitudinal axis, a stent disposed about the distal end of the catheter, and a stent protector. The stent protector has a stent covering portion disposed about the stent and a catheter engagement portion that removably engages the stent protector to the catheter assembly. The stent covering portion is disposed about the stent without substantially engaging the stent.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: November 14, 2017
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Joel Wasdyke, Michael D. Johnson, Shawn Sorenson, Raymond Adney, Ram Periakaruppan, Matt Heidner, Sean McNulty, Pu Zhou