Abstract: Described herein are silicone-containing acrylic polymers useful, for example, in transdermal drug delivery compositions, to methods of making and using them, to transdermal drug delivery compositions comprising them, and to methods of making and using such transdermal drug delivery compositions. The polymers are particular suitable for formulating amine drugs, such as amphetamine, methylphenidate, rivastigmine, paroxetine and clonidine.

Abstract: Described are transdermal drug delivery systems for the transdermal administration of tertiary amine drugs, such as rivastigmine, fentanyl or rotigotine, comprising a polymer matrix comprising a free base form of the drug and at least one carboxyl group-containing compound. In some embodiments, the systems include a rate-controlling membrane and a skin-contacting face adhesive apart from the polymer matrix.

Abstract: Described herein are silicone-containing acrylic polymers useful, for example, in transdermal drug delivery compositions, to methods of making and using them, to transdermal drug delivery compositions comprising them, and to methods of making and using such transdermal drug delivery compositions. The polymers are particular suitable for formulating amine drugs, such as amphetamine, methylphenidate, rivastigmine, paroxetine and clonidine.

Abstract: Described are pressure-sensitive adhesive polymers (PSAs) useful, for example, for application to the skin, such as in the field of transdermal drug delivery. The PSAs include polar groups modeled on one or more polar portions of skin lipids, which contribute to good skin adhesion properties. Methods of making the PSAs, compositions comprising them, and methods of making and using them also are provided.

Abstract: Described are pressure-sensitive adhesive polymers (PSAs) useful, for example, for application to the skin, such as in the field of transdermal drug delivery. The PSAs include polar groups modeled on one or more polar portions of skin lipids, which contribute to good skin adhesion properties. Methods of making the PSAs, compositions comprising them, and methods of making and using them also are provided.

Abstract: The present invention relates to gastric retention delivery systems and controlled release compositions containing a pharmaceutically acceptable active agent and a delivery agent.

Abstract: This invention relates to microparticles and/or nanoparticles containing a delivery agent and/or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent.

Abstract: The present application relates to a train smoke and fire alarm communication method based on independent modules combination and a 3U chassis structure. By externally connecting a carriage number connector X4 of an IO board to an address line to identify a carriage number, and invoking a detector configuration; acquiring temperature information and smoke concentration information by detectors and transmitting the same to a CPU board to be processed; by the CPU board, determining the acquired information, and outputting alarm information, and transmitting the alarm information to an HMI display screen in a cab; interrupting signals output between the IO board and a train safety loop, and transmitting the alarm information to the HMI display screen in the cab, and lightening a red alarm indicator on the DISP board; and by a DS board, Enet board and wireless board, collecting, storing and uploading the information.

Abstract: Oral insulin formulations and processes for preparing oral insulin formulations are provided.

Abstract: The present application relates to a train smoke and fire alarm communication method based on independent modules combination and a 3U chassis structure. By externally connecting a carriage number connector X4 of an IO board to an address line to identify a carriage number, and invoking a detector configuration; acquiring temperature information and smoke concentration information by detectors and transmitting the same to a CPU board to be processed; by the CPU board, determining the acquired information, and outputting alarm information, and transmitting the alarm information to an HMI display screen in a cab; interrupting signals output between the IO board and a train safety loop, and transmitting the alarm information to the HMI display screen in the cab, and lightening a red alarm indicator on the DISP board; and by a DS board, Enet board and wireless board, collecting, storing and uploading the information.

Abstract: Compositions for the transdermal delivery of methylphenidate in a flexible, finite form are described. The compositions comprise a polymer matrix that includes methylphenidate or a pharmaceutically acceptable salt and at least one acrylic polymer that is non-reactive with methylphenidate. Methods using the compositions to achieve transdermal delivery of methylphenidate or for treating Attention Deficit Disorder (ADD) and/or Attention Deficit/Hyperactivity Disorder (ADHD), postural orthostatic tachycardia syndrome, or narcolepsy also are described.

Abstract: Described are methods for oral administration of therapeutic proteins and peptides, more specifically to the oral administration of therapeutic proteins and peptides with gastric acid modulators, and compositions of comprising a gastric acid modulator and a protein or peptide.

Abstract: Described are transdermal pharmaceutical compositions exhibiting reduced skin irritation potential comprising a steroid and an antioxidant, useful for reducing the skin irritation associated with the use of transdermal drug delivery compositions. Methods of making and using the compositions also are described.

Abstract: Multi-polymer compositions for the transdermal delivery of drugs, such as amine-functional drugs, in a flexible, finite form are described. The compositions comprise a polymer matrix that includes a drug or a pharmaceutically acceptable salt thereof and a polymer matrix comprising acrylic polymer(s), polyisobutylene polymer(s) and styrene-isoprene-styrene block copolymer(s). Methods of manufacturing and methods of using the compositions also are described.

Abstract: Described are pressure-sensitive adhesive polymers (PSAs) useful, for example, for application to the skin, such as in the field of transdermal drug delivery. The PSAs include polar groups modeled on one or more polar portions of skin lipids, which contribute to good skin adhesion properties. Methods of making the PSAs, compositions comprising them, and methods of making and using them also are provided.

Abstract: The present invention provides a topical composition comprising (a) at least one delivery agent compound and (b) a cromoglycic acid compound. Methods of treatment, and methods of preparing the topical composition are also provided.

Abstract: Described are oligomeric/polymeric silicone fluids useful in transdermal drug delivery systems. Also described are compositions for the transdermal delivery of a drug comprising a drug-containing polymer matrix comprising a drug; a carrier polymer, and an oligomeric/polymeric silicone fluid having repeating —Si(CH3)2—O— units. Related methods and uses also are described.

Abstract: Described are pressure-sensitive adhesive polymers (PSAs) useful, for example, for application to the skin, such as in the field of transdermal drug delivery. The PSAs include polar groups modeled on one or more polar portions of skin lipids, which contribute to good skin adhesion properties. Methods of making the PSAs, compositions comprising them, and methods of making and using them also are provided.

Abstract: Described are transdermal drug delivery systems for the transdermal administration of agomelatine. Methods of making and using such systems also are described.

Abstract: Multi-polymer compositions for the transdermal delivery of drugs, such as amine-functional drugs, in a flexible, finite form are described. The compositions comprise a polymer matrix that includes a drug or a pharmaceutically acceptable salt thereof and a polymer matrix comprising acrylic polymer(s), polyisobutylene polymer(s) and styrene-isoprene-styrene block copolymer(s). Methods of manufacturing and methods of using the compositions also are described.