Patents by Inventor Puhui Li

Puhui Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fused tricyclic heterocycle compounds and therapeutic uses thereof
    Patent number: 11535633
    Abstract: This application discloses a new class of fused tricyclic heterocycles of formula (I), preparation methods thereof, pharmaceutical compositions comprising these compounds, and pharmaceutically acceptable salts, solvates, or prodrugs thereof, and their uses for the treatment of diseases in which modulation of STING is beneficial, for example, cancers, pre-cancerous disorders, and viral infections.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: December 27, 2022
    Assignees: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Dong Liu, Lei Chen, Linghang Zhuang, Puhui Li, Xinzhu Zhang, Chunying Song, Matthew Miller, Qiyue Hu, Yuna Yan, Feng He, Weikang Tao
  • COMPOUNDS AS BRUTON TYROSINE KINASE INHIBITORS, PREPARATION METHODS AND MEDICAL APPLICATIONS THEREOF
    Publication number: 20220169645
    Abstract: This application discloses Bruton Tyrosine Kinase (BTK) inhibitors of the general formula (IM) and analogs thereof, pharmaceutical compositions containing these compounds, methods of preparing them, and use of these compounds as therapeutic agents for the treatment of various disorders related to the excessive BTK activity, including cancers, immune disorders, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders, and neurological disorders.
    Type: Application
    Filed: December 2, 2021
    Publication date: June 2, 2022
    Inventors: Puhui Li, Yinfa Yan, Jian Liu, Dong Liu, Chunying Song, Suxing Liu
  • TRICYCLIC COMPOUNDS AS STING AGONISTS, AND PREPARATION METHODS AND MEDICINAL USES THEREOF
    Publication number: 20220056044
    Abstract: Compounds of formula (I) useful as agonists of stimulator of interferon genes (STING), the preparation method therefor, pharmaceutical compositions comprising the compounds, and the pharmaceutical uses for the treatment of STING-mediated diseases or disorders are disclosed.
    Type: Application
    Filed: December 14, 2019
    Publication date: February 24, 2022
    Inventors: Dong Liu, Puhui Li, Linghang Zhuang, Fengqi Zhang, Lei Chen, Xinzhu Zhang, Chunying Song, Suxing Liu, Matthew Miller, Qiyue Hu, Yuna Yan, Jing Li, Feng He, Weikang Tao
  • TYROSINE KINASE 2 INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF
    Publication number: 20220009910
    Abstract: This application discloses Tyk-2 inhibitors represented by the general formula (I) and analogs thereof, pharmaceutical compositions containing these compounds, method of preparing them, and use of these compounds as therapeutic agents for the treatment of diseases or conditions associated with Tyk-2 activity, such as autoimmune diseases and cancers.
    Type: Application
    Filed: July 10, 2021
    Publication date: January 13, 2022
    Inventors: Linghang Zhuang, Jian Liu, Yinfa Yan, Puhui Li, Yu Zhou, Suxing Liu
  • TYROSINE KINASE 2 INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF
    Publication number: 20220002267
    Abstract: Compounds of formula (I) useful as tyrosine kinase 2 (Tyk2) inhibitors, pharmaceutical compositions containing these compounds, methods of using the pharmaceutical compositions in the treatment of various disorders related to the regulation of Tyk2 activity, and methods of preparing these compounds are disclosed.
    Type: Application
    Filed: June 24, 2021
    Publication date: January 6, 2022
    Inventors: Linghang Zhuang, Jian Liu, Heping Wu, Puhui Li, Yu Zhou, Suxing Liu
  • FUSED TRICYCLIC HETEROCYCLE COMPOUNDS AND THERAPEUTIC USES THEREOF
    Publication number: 20210300944
    Abstract: This application discloses a new class of fused tricyclic heterocycles of formula (I), preparation methods thereof, pharmaceutical compositions comprising these compounds, and pharmaceutically acceptable salts, solvates, or prodrugs thereof, and their uses for the treatment of diseases in which modulation of STING is beneficial, for example, cancers, pre-cancerous disorders, and viral infections.
    Type: Application
    Filed: June 28, 2019
    Publication date: September 30, 2021
    Inventors: Dong Liu, Lei Chen, Linghang Zhuang, Puhui Li, Xinzhu Zhang, Chunying Song, Matthew Miller, Qiyue Hu, Yuna Yan, Feng He, Weikang Tao