Patents by Inventor Pulak Nath

Pulak Nath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11525879
    Abstract: A nuclear magnetic resonance (NMR) system is configured to detect combinatorial signatures stemming from homonuclear and heteronuclear J-couplings. The system comprises a pre-polarization system, a detector, and NMR electronics, wherein the detector includes an NMR magnet with a magnetic field of strength between 300 mT and 10 ?T.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: December 13, 2022
    Assignee: Triad National Security, LLC
    Inventors: Robert F. Williams, Michelle A. Espy, Derrick C. Kaseman, Jacob Luther Yoder, Per Erik Magnelind, Algis V. Urbaitis, Michael Timothy Janicke, Ryszard Michalczyk, Jurgen G. Schmidt, Pulak Nath, Scarlett Widgeon Paisner, Tammie Renee Nelson
  • Patent number: 11340181
    Abstract: A nuclear magnetic resonance (NMR) system is configured to detect chemical threat material. The system comprises a magnet configured to generate a magnetic field of about 300 millitesla or less; and a probe configured to detect nuclear relaxation of at least two nuclei selected from the group consisting of 1H, 19F, 31P and 14N, and detect the spin density of nuclei selected from the group consisting of 1H, 19F, 31P and 14N, following excitation.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: May 24, 2022
    Assignee: Triad National Security, LLC
    Inventors: Robert F. Williams, Michelle A. Espy, Jacob Luther Yoder, Derrick C. Kaseman, Per Erik Magnelind, Algis V. Urbaitis, Michael Timothy Janicke, Ryszard Michalczyk, Jurgen G. Schmidt, Pulak Nath, Scarlett Widgeon Paisner
  • Patent number: 11287358
    Abstract: Devices that include a liquid chamber including at least two ports, wherein the opening of a first port is larger than the opening of a second port, an air chamber including at least one port, and a membrane located between the liquid chamber and the air chamber, and a pressure sensor coupled to the port in the air chamber are provided. Systems including the disclosed devices are also provided. The systems include liquid in the liquid chamber of the device. Methods of using the devices and systems include measuring one or more properties of a liquid by flowing the liquid through the liquid chamber of the system and measuring the pressure produced due to the difference in size of the ports in the liquid chamber.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: March 29, 2022
    Assignee: Triad National Security, LLC
    Inventors: Pulak Nath, Jackson Henry McFall, Dylan Chance Purcell, Jen-Huang Huang
  • Patent number: 10982181
    Abstract: Devices and systems for cell culture that include one or more hollow fibers or channels integrated into a chamber are provided. The hollow fibers or channels and/or the chamber are seeded with one or more cell types. Methods of co-culturing two or more cell types in the devices are also provided.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: April 20, 2021
    Assignee: Triad National Security, LLC
    Inventors: Pulak Nath, Jen-Huang Huang
  • Patent number: 10908149
    Abstract: Disclosed herein are embodiments of devices for managing fluid transport. In particular disclosed embodiments, the devices are used to manage fluid transport in reactor systems, such as bio-assessment systems, chemical synthesis reactors, and the like. The devices disclosed herein include fluid management devices, reservoir assemblies, valving systems, pumps, and combinations thereof. The devices disclosed herein are cost-efficient and user-friendly and can be implemented in a variety of reactor systems.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: February 2, 2021
    Assignee: Triad National Security, LLC
    Inventors: Rashi Iyer, Pulak Nath, Jen-Huang Huang
  • Publication number: 20200378910
    Abstract: A nuclear magnetic resonance (NMR) system is configured to detect chemical threat material. The system comprises a magnet configured to generate a magnetic field of about 300 millitesla or less; and a probe configured to detect nuclear relaxation of at least two nuclei selected from the group consisting of 1H, 19F, 31P and 14N, and detect the spin density of nuclei selected from the group consisting of 1H, 19F, 31P and 14N, following excitation.
    Type: Application
    Filed: March 2, 2020
    Publication date: December 3, 2020
    Applicant: Triad National Security, LLC
    Inventors: Robert F. Williams, Michelle A. Espy, Jacob Luther Yoder, Derrick C. Kaseman, Per Erik Magnelind, Algis V. Urbaitis, Michael Timothy Janicke, Ryszard Michalczyk, Jurgen G. Schmidt, Pulak Nath, Scarlett Widgeon Paisner
  • Publication number: 20200355770
    Abstract: A nuclear magnetic resonance (NMR) system is configured to detect combinatorial signatures stemming from homonuclear and heteronuclear J-couplings. The system comprises a pre-polarization system, a detector, and NMR electronics, wherein the detector includes an NMR magnet with a magnetic field of strength between 300 mT and 10 ?T.
    Type: Application
    Filed: March 2, 2020
    Publication date: November 12, 2020
    Applicant: Triad National Security, LLC
    Inventors: Robert F. Williams, Michelle A. Espy, Derrick C. Kaseman, Jacob Luther Yoder, Per Erik Magnelind, Algis V. Urbaitis, Michael Timothy Janicke, Ryszard Michalczyk, Jurgen G. Schmidt, Pulak Nath, Scarlett Widgeon Paisner, Tammie Renee Nelson
  • Patent number: 10737261
    Abstract: The present disclosure concerns embodiments of reversibly bonded devices that comprise a reversible bonding component. The reversible bonding component is able to exhibit strong adhesive properties so as to couple device components, but upon exposure to an energy source, the strong adhesive properties are weakened. By weakening the adhesive strength of the reversible bonding component, the device can be deconstructed to access internal biological samples for analysis and characterization.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: August 11, 2020
    Assignee: Triad National Security, LLC
    Inventors: Pulak Nath, Jen-Huang Huang
  • Patent number: 10634665
    Abstract: Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device embodiments and various components used therein that can be used in combination with the lung organ devices disclosed herein. In some embodiments, the disclosed devices can be used to determine drug toxicity and also can be used with one or more disease models to determine methods of treating disease.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: April 28, 2020
    Assignees: Triad National Security, LLC, Vanderbilt University
    Inventors: Rashi Iyer, Jen-Huang Huang, Pulak Nath, Jennifer Harris, John P. Wikswo, Jr.
  • Patent number: 10564148
    Abstract: Disclosed herein are media for culture of cells, tissues, and/or organs. The media formulations disclosed herein can be used to support growth, viability, and/or function of one or more than one cell type, tissue, or organ. In some embodiments, one or more cell types, tissues, organ devices, and/or organs are contacted with a disclosed culture medium under conditions sufficient to support growth, viability, and/or function of the cell types, tissues, and/or organs. The disclosed media can be used in methods of culturing multiple cell types, and in some examples, is used in a platform device including one or more organ devices, for example, by circulating the medium through the one or more organ devices in the platform.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: February 18, 2020
    Assignees: Triad National Security, LLC, CFD Research Corporation
    Inventors: Rashi Iyer, Jennifer F. Harris, Jen-Huang Huang, Pulak Nath, Andrzej Przekwas
  • Patent number: 10408821
    Abstract: Disclosed herein are devices that include a top chamber including at least one port, a bottom chamber including at least one inlet and at least one outlet, wherein the opening of the at least one inlet is smaller than the opening of the at least one outlet, and a membrane located between the top chamber and the bottom chamber, wherein the membrane is fluidly coupled with the top chamber and the bottom chamber. Also disclosed herein are systems including the disclosed devices. The systems include liquid in one or more of the chambers of the device. Methods of using the devices and systems include producing a vacuum by flowing a liquid through the bottom chamber of the system. Due to the difference in size of the inlet and outlet in the bottom chamber, a vacuum is produced in the top chamber.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: September 10, 2019
    Assignee: Triad National Security, LLC
    Inventors: Pulak Nath, Jen-Huang Huang
  • Patent number: 10400915
    Abstract: Disclosed herein are embodiments of magnetically controlled valve and pump systems that can be used to control and facilitate fluid flow in fluidic devices. Various types of magnetically controlled valves and pumps are described as well as methods of magnetically-controlling such valves and pumps.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: September 3, 2019
    Assignee: Triad National Security, LLC
    Inventors: Pulak Nath, Jen-Huang Huang
  • Publication number: 20180066220
    Abstract: Devices and systems for cell culture that include one or more hollow fibers or channels integrated into a chamber are provided. The hollow fibers or channels and/or the chamber are seeded with one or more cell types. Methods of co-culturing two or more cell types in the devices are also provided.
    Type: Application
    Filed: September 6, 2017
    Publication date: March 8, 2018
    Applicant: Los Alamos National Security, LLC
    Inventors: Pulak Nath, Jen-Huang Huang
  • Publication number: 20170307594
    Abstract: Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device embodiments and various components used therein that can be used in combination with the lung organ devices disclosed herein. In some embodiments, the disclosed devices can be used to determine drug toxicity and also can be used with one or more disease models to determine methods of treating disease.
    Type: Application
    Filed: September 24, 2015
    Publication date: October 26, 2017
    Applicant: Los Alamos National Security, LLC
    Inventors: Rashi Iyer, Jen-Huang Huang, Pulak Nath, Jennifer Harris
  • Publication number: 20170299578
    Abstract: Disclosed herein are devices that include a top chamber including at least one port, a bottom chamber including at least one inlet and at least one outlet, wherein the opening of the at least one inlet is smaller than the opening of the at least one outlet, and a membrane located between the top chamber and the bottom chamber, wherein the membrane is fluidly coupled with the top chamber and the bottom chamber. Also disclosed herein are systems including the disclosed devices. The systems include liquid in one or more of the chambers of the device. Methods of using the devices and systems include producing a vacuum by flowing a liquid through the bottom chamber of the system. Due to the difference in size of the inlet and outlet in the bottom chamber, a vacuum is produced in the top chamber.
    Type: Application
    Filed: April 14, 2017
    Publication date: October 19, 2017
    Applicant: Los Alamos National Security, LLC
    Inventors: Pulak Nath, Jen-Huang Huang
  • Publication number: 20170298966
    Abstract: Disclosed herein are embodiments of magnetically controlled valve and pump systems that can be used to control and facilitate fluid flow in fluidic devices. Various types of magnetically controlled valves and pumps are described as well as methods of magnetically-controlling such valves and pumps.
    Type: Application
    Filed: April 14, 2017
    Publication date: October 19, 2017
    Applicant: Los Alamos National Security, LLC
    Inventors: Pulak Nath, Jen-Huang Huang
  • Publication number: 20170291173
    Abstract: Disclosed herein are embodiments of devices for managing fluid transport. In particular disclosed embodiments, the devices are used to manage fluid transport in reactor systems, such as bio-assessment systems, chemical synthesis reactors, and the like. The devices disclosed herein include fluid management devices, reservoir assemblies, valving systems, pumps, and combinations thereof. The devices disclosed herein are cost-efficient and user-friendly and can be implemented in a variety of reactor systems.
    Type: Application
    Filed: September 24, 2015
    Publication date: October 12, 2017
    Applicant: Los Alamos National Security, LLC
    Inventors: Rashi Iyer, Pulak Nath, Jen-Huang Huang
  • Publication number: 20170275587
    Abstract: Disclosed herein are media for culture of cells, tissues, and/or organs. The media formulations disclosed herein can be used to support growth, viability, and/or function of one or more than one cell type, tissue, or organ. In some embodiments, one or more cell types, tissues, organ devices, and/or organs are contacted with a disclosed culture medium under conditions sufficient to support growth, viability, and/or function of the cell types, tissues, and/or organs. The disclosed media can be used in methods of culturing multiple cell types, and in some examples, is used in a platform device including one or more organ devices, for example, by circulating the medium through the one or more organ devices in the platform.
    Type: Application
    Filed: September 24, 2015
    Publication date: September 28, 2017
    Inventors: Rashi Iyer, Jennifer F. Harris, Jen-Huang Huang, Pulak Nath, Andrzej Przekwas
  • Patent number: 9322013
    Abstract: Described herein are methods and systems for harvesting, collecting, separating and/or dewatering algae using iron based salts combined with a magnetic field gradient to separate algae from an aqueous solution.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: April 26, 2016
    Assignee: Los Alamos National Security, LLC
    Inventors: Pulak Nath, Scott N. Twary
  • Publication number: 20140242663
    Abstract: Described herein are methods and systems for harvesting, collecting, separating and/or dewatering algae using iron based salts combined with a magnetic field gradient to separate algae from an aqueous solution.
    Type: Application
    Filed: February 25, 2014
    Publication date: August 28, 2014
    Applicant: Los Alamos National Security, LLC
    Inventors: Pulak Nath, Scott N. Twary