Patents by Inventor Pulla Reddy Muddasani

Pulla Reddy Muddasani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL PROCESS FOR THE PREPARATION OF ACALABRUTINIB AND ITS INTERMEDIATES
    Publication number: 20230081911
    Abstract: The present invention relates to an improved and industrially viable process for the preparation of Acalabrutinib and its Intermediates. The present invention involves less expensive reagents, solvents and the process conditions can be easily adopted for commercial scale. The present invention relates to process for the preparation Acalabrutinib of formula (1) and process for the preparation of Acalabrutinib key starting material.
    Type: Application
    Filed: December 1, 2020
    Publication date: March 16, 2023
    Inventors: Shankar Reddy BUDIDETI, Srinivasa Krishna Murthy KONDURI, Jagan Mohan Reddy SANAPUREDDY, Ravi Kumar REMELLA, Sandeep Kumar THOOTA, Sunitha KOTHAMUNIREDDYGARI, Pulla Reddy MUDDASANI, Venkaiah Chowdary NANNAPANENI
  • Process for the preparation of Tipiracil hydrochloride and intermediates thereof
    Patent number: 11465988
    Abstract: The present invention provides a process for the preparation of Tipiracil HCl of Formula (I) and intermediate thereof with improved yields and purities.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: October 11, 2022
    Assignee: NATCO PHARMA LIMITED
    Inventors: Srinivasulu Sakkani, Uma Naresh Babu Kotra, Dharmender Ragidi, Buchappa Gongalla, Durga Prasad Konakanchi, Pulla Reddy Muddasani, Venkaiah Chowdary Nannapaneni
  • A PROCESS FOR THE PREPARATION OF VENETOCLAX AND ITS POLYMORPHS THEREOF
    Publication number: 20220259204
    Abstract: The present invention relates to a process for the preparation of 4-(4-{[2-(4-chlorophenyl)-4,4dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b] pyridin-5-yloxy)benzamide) compound of formula-1 which is represented by the following structural formula:
    Type: Application
    Filed: July 8, 2020
    Publication date: August 18, 2022
    Inventors: Balakrishna Reddy SIRIGIREDDY, Veeraswamy BALINA, Sreenivas RACHAKONDA, Veerender MURKI, Durga Prasad KONAKANCHI, Pulla Reddy MUDDASANI, Venkaiah Chowdary NANNAPANENI
  • PROCESS FOR THE PREPARATION OF HIGH PURE ERIBULIN AND ITS MESYLATE SALT
    Publication number: 20220089607
    Abstract: The present invention relates to a process for the preparation of high pure Eribulin and Eribulin Mesylate. The present invention involves preparation of high pure Eribulin and its mesylate salt involving chiral acid addition salts of Eribulin.
    Type: Application
    Filed: November 27, 2019
    Publication date: March 24, 2022
    Inventors: Prabhakar DIVYA, Srinivasu KASA, Durga Prasad KONAKANCHI, Ramesh DANDALA, Pulla Reddy MUDDASANI, Venkaiah Chowdary NANNAPANENI
  • IMPROVED PROCESS FOR THE PREPARATION OF TIPIRACIL HYDROCHLORIDE AND INTERMEDIATES THEREOF
    Publication number: 20220056016
    Abstract: The present invention provides a process for the preparation of Tipiracil HCl of Formula (I) and intermediate thereof with improved yields and purities.
    Type: Application
    Filed: December 13, 2019
    Publication date: February 24, 2022
    Applicant: NATCO PHARMA LIMITED
    Inventors: Srinivasulu SAKKANI, Uma Naresh Babu KOTRA, Dharmender RAGIDI, Buchappa GONGALLA, Durga Prasad KONAKANCHI, Pulla Reddy MUDDASANI, Venkaiah Chowdary NANNAPANENI
  • Process for the preparation of N-(3-ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin-4-amine dihydrochloride
    Patent number: 11091470
    Abstract: Present invention relates to an improved process for the preparation of N—(3-ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin-4-amine dihydrochloride of formula-I.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: August 17, 2021
    Assignee: NATCO PHARMA LIMITED
    Inventors: Pulla Reddy Muddasani, Shankar Reddy Budideti, Srinivasa Krishna Murthy Konduri, Nagalingam Samatham, Venkaiah Chowdary Nannapaneni
  • Intermediates for the preparation of eribulin thereof
    Patent number: 11008296
    Abstract: The present invention relates to novel intermediates of Eribulin and process for the preparation of the same. The process of the present invention is commercially viable and can be easily adopted for plant scale operations. The present invention relates to tetrahydrofuran compounds of formula I, X, XI, D and B.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: May 18, 2021
    Assignee: Natco Pharma Limited
    Inventors: Bulli Babi Vipparla, Sreenivas Nagapuri, Sathaiah Kandula, Janaki Rama Rao Ravi, Durga Prasad Konakanchi, Pulla Reddy Muddasani, Venkaiah Chowdary Nannapaneni
  • AN IMPROVED PROCESS FOR THE PREPARATION OF RIBOCICLIB SUCCINATE AND ITS NOVEL CRYSTALLINE FORMS THEREOF
    Publication number: 20210122754
    Abstract: The present invention relates to an improved process for the preparation of 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate (1/1) compound of formula-1a and its novel crystalline forms.
    Type: Application
    Filed: January 10, 2019
    Publication date: April 29, 2021
    Inventors: Arunkumar THIRIVEEDHI, Swapna KONDAVEETI, Sathish THUMATI, Naresh GHANTA, Janaki Rama Rao RAVI, Durga Prasad KONAKANCHI, Pulla Reddy MUDDASANI, Venkaiah Chowdary NANNAPANENI
  • Process for the preparation of amorphous idelalisib
    Patent number: 10870650
    Abstract: The present invention relates to a process for the preparation of stable and 5 pure amorphous form of Idelalisib. Further, the present process is simple, more economical, cost effective and efficient method of manufacturing that is suitable for industrial scale-up having a high degree of chromatographic purity.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: December 22, 2020
    Assignee: NATCO PHARMA LIMITED
    Inventors: Amala Kompella, Sreenivas Rachakonda, Venugopala Krishna Gampa, Subhash Kusumba, Durga Prasad Konakanchi, Pulla Reddy Muddasani, Venkaiah Chowdary Nannapaneni
  • AN IMPROVED PROCESS FOR THE PREPARATION OF N-(3-ETHYNYLPHENYL)-7-METHOXY-6-(3- MORPHOLINOPROPOXY) QUINAZOLIN -4-AMINE DIHYDROCHLORIDE
    Publication number: 20200331899
    Abstract: Present invention relates to an improved process for the preparation of N-(3-ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin-4-amine dihydrochloride of formula-I.
    Type: Application
    Filed: June 19, 2017
    Publication date: October 22, 2020
    Inventors: Pulla Reddy MUDDASANI, Shankar Reddy BUDIDETI, Srinivasa Krishna Murthy KONDURI, Nagalingam SAMATHAM, Venkaiah Chowdary NANNAPANENI
  • INTERMEDIATES FOR THE PREPARATION OF ERIBULIN THEREOF
    Publication number: 20200299248
    Abstract: The present invention relates to novel intermediates of Eribulin and process for the preparation of the same. The process of the present invention is commercially viable and can be easily adopted for plant scale operations. The present invention relates to tetrahydrofuran compounds of formula I, X, XI, D and B.
    Type: Application
    Filed: November 20, 2018
    Publication date: September 24, 2020
    Inventors: Bulli Babi VIPPARLA, Sreenivas NAGAPURI, Sathaiah KANDULA, Janaki Rama Rao RAVI, Durga Prasad KONAKANCHI, Pulla Reddy MUDDASANI, Venkaiah Chowdary NANNAPANENI
  • Process for the preparation of Ibrutinib
    Patent number: 10626117
    Abstract: The present invention relates to an improved process for the preparation of Ibrutinib with high purity and high yields. The present process is cost effective and feasible in large scale production also. The present process avoids the mitsunobu reagent conditions also. The present Invention also relates to a process for the preparation of Crystalline form A and Crystalline form C of Ibrutinib.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: April 21, 2020
    Assignee: NATCO PHARMA LIMITED
    Inventors: Pulla Reddy Muddasani, Shankar Reddy Budideti, Veerababu Madalapu, Anitha Gattu, Bala Ankireddy Konda, Venkaiah Chowdary Nannapaneni
  • Modified process for the preparation of Ceritinib and amorphous form of Ceritinib
    Patent number: 10604505
    Abstract: The present invention is related to an improved process for the preparation of Ceritinib with high yield and high purity. The present process is cost effective and feasible in large scale production also. The present invention also related to a stable amorphous form of Ceritinib and its preparation. The present invention also relates to a process for the preparation of Crystalline form A of Ceritinib.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: March 31, 2020
    Assignee: Natco Pharma Limited
    Inventors: Durga Prasad Konakanchi, Subba Rao Pula, Muni Bhaskar Pallooru, Radha Rani Samatham, Ramakrishna Pilli, Lakshmana Viswa Venkata Pavan Kumar Maddula, Sandeep Karnam, Pulla Reddy Muddasani, Kali Satya Bhujanga Rao Adibhatla, Venkaiah Chowdary Nannapaneni
  • PROCESS FOR THE PREPARATION OF AMORPHOUS IDELALISIB
    Publication number: 20200095249
    Abstract: The present invention relates to a process for the preparation of stable and 5 pure amorphous form of Idelalisib. Further, the present process is simple, more economical, cost effective and efficient method of manufacturing that is suitable for industrial scale-up having a high degree of chromatographic purity.
    Type: Application
    Filed: April 11, 2018
    Publication date: March 26, 2020
    Inventors: Amala KOMPELLA, Sreenivas RACHAKONDA, Venugopala Krishna GAMPA, Subhash KUSUMBA, Durga Prasad KONAKANCHI, Pulla Reddy MUDDASANI, Venkaiah Chowdary NANNAPANENI
  • AN IMPROVED PROCESS FOR THE PREPARATION OF REGORAFENIB
    Publication number: 20190300484
    Abstract: The present invention relates to an improved process for the preparation of Regorafenib with genotoxic impurities at well below threshold limit and high yield. The present invention also relates to an improved process for the preparation of regorafenib form-I with high purity.
    Type: Application
    Filed: March 31, 2016
    Publication date: October 3, 2019
    Inventors: Pulla Reddy MUDDASANI, Shankar Reddy BUDIDETI, Srinivasachary CHINTALAPATI, Tirupathi KOTTE, Sambasiva Rao TALASILA, Venkaiah Chowdary NANNAPANENI
  • AN IMPROVED PROCESS FOR THE PREPARATION OF IBRUTINIB
    Publication number: 20190241567
    Abstract: The present invention relates to an improved process for the preparation of Ibrutinib with high purity and high yields. The present process is cost effective and feasible in large scale production also. The present process avoids the mitsunobu reagent conditions also. The present Invention also relates to a process for the preparation of Crystalline form A and Crystalline form C of Ibrutinib.
    Type: Application
    Filed: February 1, 2017
    Publication date: August 8, 2019
    Inventors: Pulla Reddy MUDDASANI, Shankar Reddy BUDIDETI, Veerababu MADALAPU, Anitha GATTU, Bala Ankireddy KONDA, Venkaiah Chowdary NANNAPANENI
  • MODIFIED PROCESS FOR THE PREPARATION OF CERITINIB AND AMORPHOUS FORM OF CERITINIB
    Publication number: 20190047983
    Abstract: The present invention is related to an improved process for the preparation of Ceritinib with high yield and high purity. The present process is cost effective and feasible in large scale production also. The present invention also related to a stable amorphous form of Ceritinib and its preparation. The present invention also relates to a process for the preparation of Crystalline form A of Ceritinib.
    Type: Application
    Filed: March 9, 2017
    Publication date: February 14, 2019
    Inventors: Durga Prasad Konakanchi, Subba Rao Pula, Muni Bhaskar Pallooru, Radha Rani Samatham, Ramakrishna Pilli, Lakhmana Viswa Venjata Pavan Kumar Maddula, Sandeep Karnam, Pulla Reddy Muddasani, Kali Satya Bhujanga Rao Ibhatla, Venkaiah Chowdary Napaneni
  • 7-(morpholinyl)-2-(N-piperazinyl) methyl thieno [2, 3-C] pyridine derivatives as anticancer drugs
    Patent number: 10106554
    Abstract: The present invention relates to novel series of substituted 7-(morpholinyl)-2-(N-piperazinyl)-methyl thieno [2, 3-c] pyridines of the following structure of formula I. Where in R1, R2, R3 and R4 are defined.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: October 23, 2018
    Assignee: NATCO PHARMA LIMITED
    Inventors: Durga Prasad Konakanchi, Subba Rao Pula, Rama Krishna Pilli, Lakshmana Viswa Venkata Pavan Kumar Maddula, Srinivasa Krishna Murthy Konduri, Janaki Rama Rao Ravi, Naga Vasanta Srinivasu Vuppalapati, Sandeep Kumar Thoota, Pulla Reddy Muddasani, Kali Satya Bhujanga Rao Adibhatla, Venkaiah Chowdary Nannapaneni
  • 7-(MORPHOLINYL)-2-(N-PIPERAZINYL) METHYL THIENO [2, 3-C] PYRIDINE DERIVATIVES AS ANTICANCER DRUGS
    Publication number: 20170320891
    Abstract: The present invention relates to novel series of substituted 7-(morpholinyl)-2-(N-piperazinyl)-methyl thieno [2, 3-c] pyridines of the following structure of formula I. Where in R1, R2, R3 and R4 are defined.
    Type: Application
    Filed: December 11, 2014
    Publication date: November 9, 2017
    Inventors: Durga Prasad KONAKANCHI, Subba Rao PULA, Rama Krishna PILLI, Lakshmana Viswa Venkata Pavan Kumar MADDULA, Srinivasa Krishna Murthy KONDURI, Janaki Rama Rao RAVI, Naga Vasanta Srinivasu VUPPALAPATI, Sandeep Kumar THOOTA, Pulla Reddy MUDDASANI, Kali Satya Bhujanga Rao ADIBHATLA, Venkaiah Chowdary NANNAPANENI
  • Process for the preparation of 2-substituted-2-(6-(substituted)-7-methylbenzo[D][1,3]dioxol-4-yl)acetic acid derivatives
    Patent number: 9227948
    Abstract: Present invention relates to an improved and commercial process for the preparation of 2-sustituted-2-(6-(substituted)-7-methylbenzo[d][1,3]dioxol-4-yl)acetic acid derivatives of formula-I the above Formula I, XII, XIII, XV, wherein R1 is a O-protecting group such as methoxymethyl, ethoxymethyl, trialkylsilyl, arylmethyl, tetrahydropyran-2-yl, allyl; X is hydroxyl, halogen, mesylate, triflate, tosylate, acetate; Y is oxygen atom, NH or sulfur atom; R2 is C1-C6 alkyl. 2,4-Dihydroxy-3-methylbenzaldehyde is selectively protected at C-4 position in the form of an ether compound of formula-XII, oxidized the aldehyde function to get the diol of formula-XIII, and condensed with ethyl glyoxalate under Casiraghi reaction conditions to get the compound of formula-XV. Compound of formula-XV is converted to compound of formula-I by conventional chemistry. Compounds of formula-I are key intermediates in the synthesis of ecteinascidines like trabectedin.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: January 5, 2016
    Assignee: Natco Pharma Limited
    Inventors: Pulla Reddy Muddasani, Manikumar Chintalapudi, Venkaiah Chowdary Nannapaneni