Patents by Inventor Pumin Zhang

Pumin Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for screening of DNA libraries and generation of recombinant DNA constructs
    Patent number: 6376192
    Abstract: A method of DNA library screening includes homologous recombination in E. coli utilizing lambda phage recombination functions. Inserting a positive selection marker such as antibiotic resistance into the target sequence by homologous recombination facilitates isolation of target sequences and requires only about 58-100 base pairs of total homology, thus allowing the use of synthetic fragments of DNA for targeting. DNA vector is designed for genomic library construction that features a novel genetic selection for inserts, automatic subcloning of isolated genomic clones and the presence of a negative selection marker adjacent to the genomic inserts to facilitate later gene targeting.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: April 23, 2002
    Assignee: Baylor College of Medicine
    Inventors: Stephen J. Elledge, Pumin Zhang, Mamie Li