Patents by Inventor Purna Chandra Ray

Purna Chandra Ray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10479787
    Abstract: The present invention provides process for preparation of dihydroxy benzoquinoline compound (III) comprising reacting dihydroxy isoquinoline compound (IV) or a salt thereof with (2-acetyl-4-methyl-pentyl)-trimethyl-ammonium iodide (V) and further converting it to tetrabenazine (I) and deutetrabenazine (II).
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: November 19, 2019
    Assignee: Lupin Limited
    Inventors: Tushar Nandkumar Despande, Dnyaneshwar Tukaram Singare, Yogesh Dadaji Pawar, Yuvraj Atmaram Chavan, Purna Chandra Ray, Girij Pal Singh
  • Publication number: 20190256498
    Abstract: The present invention provides novel crystalline form L1 of daclatasvir dihydrochloride wherein the diffraction peaks at 5.35, 6.04, 6.76, 8.65, 9.21, 10.35, 10.32, 10.75, 11.04, 11.66, 12.95, 13.56, 16.06, 18.11, 20.58, 22.18, 23.27±0.2 degree two theta in an X-ray diffraction pattern. The present invention provides novel crystalline form L2 of daclatasvir dihydrochloride wherein the diffraction peaks at 8.27, 9.54, 11.06, 13.61, 15.34, 19.01, 22.26, 23.24, 24.73, 25.35±0.2 degree two theta in an X-ray diffraction pattern. The present invention further provides process for preparation of crystalline forms L1 and L2 of daclatasvir dihydrochloride.
    Type: Application
    Filed: July 7, 2017
    Publication date: August 22, 2019
    Inventors: Palash SANPHUI, Radhakrishna Bhikaji SHIVDAVKAR, Gurvinder Pal SINGH, Purna Chandra RAY, Girij Pal SINGH, Vikas Ashokrao SADAPHAL, Lalitkumar Dilipising RAJPUT, Hemraj Mahadeorao LANDE
  • Publication number: 20190248773
    Abstract: The present invention provides improved, commercially viable and consistently reproducible processes for the preparation of pure and stable crystalline Raltegravir potassium Form 3 and pharmaceutical composition thereof.
    Type: Application
    Filed: September 13, 2017
    Publication date: August 15, 2019
    Inventors: Purna Chandra Ray, Samir Shanteshwar Shabade, Surinder Kumar Arora, D. Rajput Lalitkumar, B. Shivdavkar Radhakrishna, G. Varade Shantanu, D. Ausekar Govind, Girij Pal Singh, Shreyas Pandurang Deshmukh, Gaurav Amrut Patil
  • Publication number: 20190135803
    Abstract: The present invention provides process for preparation of dihydroxy benzoquinoline compound (III) comprising reacting dihydroxy isoquinoline compound (IV) or a salt thereof with (2-acetyl-4-methyl-pentyl)-trimethyl-ammonium iodide (V) and further converting it to tetrabenazine (I) and deutetrabenazine (II).
    Type: Application
    Filed: April 12, 2017
    Publication date: May 9, 2019
    Applicant: Lupin Limited
    Inventors: Tushar Nandkumar DESPANDE, Dnyaneshwar Tukaram SINGARE, Yogesh Dadaji PAWAR, Yuvraj Atmaram CHAVAN, Purna Chandra RAY, Girij Pal SINGH
  • Publication number: 20180230097
    Abstract: The present invention provides an improved process for preparation of an intermediate of apremilast. The present invention also provides an improved process for preparation of apremilast. This invention also provides novel polymorphs of apremilast. The present invention also provides pharmaceutical compositions of novel polymorphs of apremilast. This invention also provides a process for preparation of novel polymorphs of apremilast, which are cost-effective, robust, and viable at plant scale.
    Type: Application
    Filed: May 26, 2016
    Publication date: August 16, 2018
    Applicant: LUPIN LIMITED
    Inventors: Palash SANPHUI, Ananda Pundlik SAPDHARE, Arunkumar Digambar PATIL, Hemraj Mahadeorao LANDE, Gurvinder Pal SINGH, Purna Chandra RAY, Nandu Bahan BHISE, Girij Pal SINGH, Mithun Dasharath SURWASE, Shantanu Gokuldas VARADE, Govind Dnyanoba AUSEKAR, Radhakrishna Bhikaji SHIVDAVKAR
  • Publication number: 20170259241
    Abstract: The present invention is directed towards a manufacturing method for an iron containing phosphate adsorbent. Said iron containing phosphate adsorbent is characterized by a PSD d(0.9) in the range of 20 ?m to 80 ?m, a BET active surface area less than 15 m2/gm and phosphate binding in the range of 35 to 60 mg/gm.
    Type: Application
    Filed: September 9, 2015
    Publication date: September 14, 2017
    Inventors: Gaurav KUMAR, Ashok Sopan YADAV, Nitesh Yashwant AMRUTKAR, Surinder Kumar ARORA, Radhakrishna SHIVDAVKAR, Purna Chandra RAY, Girij Pal SINGH
  • Publication number: 20160185766
    Abstract: Provided herein are novel salts of raltegravir, viz., meglumine salt, erbumine salt, ammonium salt, tris salt and L-arginine salt of raltegravir and processes for their preparation.
    Type: Application
    Filed: September 16, 2015
    Publication date: June 30, 2016
    Inventors: Purna Chandra Ray, Ashok Sopanrao Yadav, Dnyaneshwar Tukaram Singare, Surinder Kumar Arora, Girij Pal Singh
  • Publication number: 20150328215
    Abstract: The present invention relates to a stable amorphous Raltegravir potassium premix, method of making and pharmaceutical composition thereof.
    Type: Application
    Filed: January 25, 2013
    Publication date: November 19, 2015
    Inventors: Surinder Kumar ARORA, Dnyaneshwar Tukaram SINGARE, Amol Dattatreya GALANDE, Purna Chandra RAY, Dilip Gopalkrishna SAOJI, Makrand AVACHAT, Girij Pal SINGH
  • Patent number: 9163009
    Abstract: The present invention provides novel salts of raltegravir, viz., meglumine salt, erbumine salt, ammonium salt, tris salt and L-arginine salt of raltegravir and processes for their preparation.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: October 20, 2015
    Assignee: Lupin Limited
    Inventors: Purna Chandra Ray, Ashok Sopanrao Yadav, Dnyaneshwar Tukaram Singare, Surinder Kumar Arora, Girij Pal Singh
  • Publication number: 20150274770
    Abstract: The present invention is related to a novel process for the preparation of ulipristal (I) that comprises reaction of 17-?-ethynyl-17-?-hydroxy-11-?-(4-N,N-dimethylamino phenyl)- 9-norpregna-4,9-diene-3-one (III) with phenyl sulphenyl chloride (IVa) or p-nitro phenyl sulphenyl chloride (Nb) in the presence of organic base and solvent to give sulfoxide (Va) or (Vb) respectively. Sulfoxides (Va) or (Vb) are reacted with alkali metal alkoxide in alcoholic solvent followed by treatment with aqueous acid. The present invention also relates to novel intermediate 11-?-(4-N,N-dimethylaminophenyl)-21(p- nitro-phenyl-sulphinyl)-19-norpregna-4(5), 9(10), 17(20) 20-tetraene, 3-one (Vb).
    Type: Application
    Filed: October 1, 2013
    Publication date: October 1, 2015
    Inventors: Purna Chandra Ray, Ajinath Tukaram Pathade, Suryaprakash Pandurang Patil, Yuvraj Atmaram Chavan, Girij Pal Singh, Dnyaneshwar Tukaram Singare, Yogesh Dadaji Pawar
  • Patent number: 9127029
    Abstract: The present invention relates to fosamprenavir calcium (Ia) substantially free of isomer impurity, (3R) tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propyl carbamate (Ib), and its process for preparation thereof. The present invention also provides fosamprenavir calcium intermediate, (S)-3-tetrahydrofuranyl-N-succinimidyl carbonate (IIa) substantially free of (R)-3-tetrahydrofuranylsuccinimidyl carbonate (IIb) and its process for preparation thereof.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: September 8, 2015
    Assignee: LUPIN LIMITED
    Inventors: Surinder Kumar Arora, Samir Shanteshwar Shabade, Gaurav Kumar, Purna Chandra Ray, Girij Pal Singh
  • Patent number: 8877947
    Abstract: The present invention relates to fosamprenavir calcium (Ia) substantially free of isomer impurity, (3R)tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propyl carbamate (Ib), and its process for preparation thereof. The present invention also provides fosamprenavir calcium intermediate, (S)-3-tetrahydrofuranyl-N-succinimidyl carbonate (IIa) substantially free of (R)-3-tetrahydrofuranylsuccinimidyl carbonate (IIb) and its process for preparation thereof.
    Type: Grant
    Filed: September 5, 2011
    Date of Patent: November 4, 2014
    Assignee: Lupin Limited
    Inventors: Surinder Kumar Arora, Samir Shanteshwar Shabade, Gaurav Kumar, Purna Chandra Ray, Girij Pal Singh
  • Publication number: 20140256959
    Abstract: The present invention relates to fosamprenavir calcium (Ia) substantially free of isomer impurity, (3R) tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propyl carbamate (Ib), and its process for preparation thereof. The present invention also provides fosamprenavir calcium intermediate, (S)-3-tetrahydrofuranyl-N-succinimidyl carbonate (IIa) substantially free of (R)-3-tetrahydrofuranylsuccinimidyl carbonate (IIb) and its process for preparation thereof.
    Type: Application
    Filed: May 23, 2014
    Publication date: September 11, 2014
    Applicant: LUPIN LIMITED
    Inventors: Surinder Kumar Arora, Samir Shanteshwar Shabade, Gaurav Kumar, Purna Chandra Ray, Girij Pal Singh
  • Publication number: 20140155607
    Abstract: The present invention provides novel salts of raltegravir, viz., meglumine salt, erbumine salt, ammonium salt, tris salt and L-arginine salt of raltegravir and processes for their preparation.
    Type: Application
    Filed: April 4, 2012
    Publication date: June 5, 2014
    Applicant: LUPIN LIMITED
    Inventors: Purna Chandra Ray, Ashok Sopanrao Yadav, Dnyaneshwar Tukaram Singare, Surinder Kumar Arora, Girij Pal Singh
  • Patent number: 8513455
    Abstract: The present invention relates to a crystalline oxybutynin base and process for preparing the same. Further, this invention discloses a process for preparing an acid addition salt of oxybutynin employing the crystalline oxybutynin base.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: August 20, 2013
    Assignee: Matrix Laboratories Limited
    Inventors: Purna Chandra Ray, Madhuresh Sethi, Sanjay Mahajan, Om Dutt Tyagi
  • Publication number: 20130174651
    Abstract: The present invention relates to fosamprenavir calcium (Ia) substantially free of isomer impurity, (3R) tetrahydro -3 -furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propyl carbamate (Ib), and its process for preparation thereof. The present invention also provides fosamprenavir calcium intermediate, (S)-3-tetrahydrofuranyl-N-succinimidyl carbonate (IIa) substantially free of (R)-3-tetrahydrofuranylsuccinimidyl carbonate (IIb) and its process for preparation thereof.
    Type: Application
    Filed: September 5, 2011
    Publication date: July 11, 2013
    Applicant: LUPIN LIMITED
    Inventors: Surinder Kumar Arora, Samir Shanteshwar Shabade, Gaurav Kumar, Purna Chandra Ray, Girij Pal Singh
  • Publication number: 20130096319
    Abstract: The present invention is related to a novel process for the preparation of amisulpride (I) which involves: methylation of 4-amino-salicylic-acid (VI) with dimethyl sulphate and base, optionally in presence of TBAB to obtain 4-amino-2-methoxy methyl benzoate (VII) and (ii) oxidation of 4-amino-2-methoxy-5-ethyl thio benzoic acid (IX) or 4-amino-2-methoxy-5-ethyl thio methyl benzoate (X) with oxidizing agent in the presence of sodium tungstate or ammonium molybdate to give 2-methoxy-4-amino-5-ethyl-sulfonyl benzoic acid (IV) or 2-methoxy-4-amino-5-ethyl-sulfonyl methyl benzoate (XI) respectively.
    Type: Application
    Filed: June 9, 2011
    Publication date: April 18, 2013
    Applicant: Lupin Limited
    Inventors: Dinesh Jayntibhai Paghdar, Mahesh Ramkumar Kolekar, Tushar Nandkumar Deshpande, Suryaprakash Pandurang Patil, Yuvraj Atmaram Chavan, Purna Chandra Ray, Girij Pal Singh
  • Publication number: 20130041166
    Abstract: The present invention provides novel process for preparation and purification of dienogest (I). The present invention provides dienogest (I) substantially free of impurities.
    Type: Application
    Filed: April 13, 2011
    Publication date: February 14, 2013
    Applicant: LUPIN LIMITED
    Inventors: Suhas Ganpat Tambe, Bhushan Bhanudas Kirange, Gurvinder Pal Singh, Purna Chandra Ray
  • Publication number: 20130005780
    Abstract: The present invention provides atazanavir sulfate substantially free of diastereomeric impurities. The present invention also provides atazanavir sulfate having D-tertiary leucine analogues less than 0.1%. The present invention further relates to an improved process for preparing atazanavir sulfate, substantially free of its diastereoisomeric impurities, which comprises of reacting diamino compound (IV) with N-methoxycarbonyl-(L)-tertiary-leucine (V) having D-isomer less than 0.1% to obtain atazanavir base; conversion of atazanavir base to atazanavir sulfate by reacting with sulfuric acid and crystallization of atazanavir sulfate from suitable organic solvent(s).
    Type: Application
    Filed: February 16, 2011
    Publication date: January 3, 2013
    Applicant: LUPIN LIMITED
    Inventors: Kumodini Kashinath Mahakal, Pal Singh, Purna Chandra Ray
  • Patent number: 8247568
    Abstract: The present invention relates to a process for the preparation of pure Rabeprazole sulfoxide using the solvent mixture for the extraction steps and this invention further relates to the process for the preparation of amorphous Rabeprazole sodium using pure rabeprazole base in presence of aqueous NaOH and water miscible solvent and adding an anti-solvent.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: August 21, 2012
    Assignee: Matrix Laboratories Ltd
    Inventors: Om Dutt Tyagi, Purna Chandra Ray, Madhuresh Kumar Sethi, Bhausaheb Chavhan