Patents by Inventor Purushotham Vemishetti

Purushotham Vemishetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10494400
    Abstract: The present disclosure relates to methods for making asunaprevir, useful treatment of Hepatitis C virus (HCV) infection, and its intermediates.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: December 3, 2019
    Assignee: Bristol-Myers Squibb Company
    Inventors: Scott A. Savage, Nathan R. Domagalski, Brendan Mack, Purushotham Vemishetti, Yuping Qiu, Michael Fenster, Daniel M. Hallow, Glenn Ferreira, Amanda Rogers, Sha Lou, Lindsay Hobson
  • Publication number: 20180155393
    Abstract: The present disclosure relates to methods for making asunaprevir, useful treatment of Hepatitis C virus (HCV) infection, and its intermediates.
    Type: Application
    Filed: June 23, 2015
    Publication date: June 7, 2018
    Inventors: Scott A. SAVAGE, Nathan R. DOMAGALSKI, Brendan MACK, Purushotham VEMISHETTI, Yuping QIU, Michael FENSTER, Daniel M. HALLOW, Glenn FERREIRA, Amanda ROGERS, Sha LOU, Lindsay HOBSON
  • Patent number: 7968555
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: June 28, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Publication number: 20100286089
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Application
    Filed: July 22, 2010
    Publication date: November 11, 2010
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Patent number: 7786300
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: August 31, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Publication number: 20090143578
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Application
    Filed: February 4, 2009
    Publication date: June 4, 2009
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Patent number: 7511139
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: March 31, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Maotang X. Zhou, Emily A. Reiff, Purushotham Vemishetti, Yadagiri R. Pendri, Ambarish K. Singh, Siva Josyula Prasad, Ulhas P. Dhokte, Xinhua Qian, Pia Mountford, Kerry B. Hartung, Helen Sailes
  • Patent number: 7205402
    Abstract: The present invention provides novel methods for the synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (III) which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.
    Type: Grant
    Filed: September 1, 2005
    Date of Patent: April 17, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Purushotham Vemishetti, Scott T. Chadwick, Carrie A. Costello, Sridhar Desikan, Emily A. Reiff
  • Patent number: 7034152
    Abstract: Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: April 25, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yadagiri R. Pendri, Chung-Pin H. Chen, Sunil S. Patel, Jeffrey M. Evans, Jing Liang, David R. Kronenthal, Gerald L. Powers, Siva Josyula Prasad, Jeffrey T. Bien, Zhongping Shi, Ramesh N. Patel, Amit Banerjee, Yeung Yu Chan, Sushil K. Rijhwani, Ambarish K. Singh, Shaopeng Wang, Milan Stojanovic, David J. Kucera, Richard P. Polniaszek, Charles Lewis, John Thottathil, Dhileepkumar Krishnamurty, Maotang X. Zhou, Purushotham Vemishetti
  • Patent number: 7012158
    Abstract: Provided are processes and synthetic intermediates useful for the preparation of ?-difluoromethylornithine (DFMO) having the formula
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: March 14, 2006
    Assignee: Skinmedica, Inc.
    Inventors: Jingyang Zhu, Scott T. Chadwick, Benjamin A. Price, Shannon X. Zhao, Carrie A. Costello, Purushotham Vemishetti
  • Publication number: 20060047115
    Abstract: The present invention provides novel methods for the synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (III) which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.
    Type: Application
    Filed: September 1, 2005
    Publication date: March 2, 2006
    Inventors: Purushotham Vemishetti, Scott Chadwick, Carrie Costello, Sridhar Desikan, Emily Reiff
  • Publication number: 20050272932
    Abstract: Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.
    Type: Application
    Filed: June 2, 2005
    Publication date: December 8, 2005
    Inventors: Maotang Zhou, Emily Reiff, Purushotham Vemishetti, Yadagiri Pendri, Ambarish Singh, Siva Prasad, Ulhas Dhokte, Xinhua Qian, Pia Mountford, Kerry Hartung, Helen Sailes
  • Publication number: 20040192912
    Abstract: Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
    Type: Application
    Filed: December 11, 2003
    Publication date: September 30, 2004
    Inventors: Yadagiri R. Pendri, Chung-Pin H. Chen, Sunil S. Patel, Jeffrey M. Evans, Jing Liang, David R. Kronenthal, Gerald L. Powers, Siva Josyula Prasad, Jeffrey T. Bien, Zhongping Shi, Ramesh N. Patel, Amit Banerjee, Yeung Yu Chan, Sushil K. Rijhwani, Ambarish K. Singh, Shaopeng Wang, Milan Stojanovic, David J. Kucera, Richard P. Polniaszek, Charles Lewis, John Thottathil, Dhileepkumar Krishnamurty, Maotang X. Zhou, Purushotham Vemishetti
  • Publication number: 20040171876
    Abstract: Provided are processes and synthetic intermediates useful for the preparation of &agr;-difluoromethylornithine (DFMO) having the formula 1
    Type: Application
    Filed: February 26, 2004
    Publication date: September 2, 2004
    Applicants: Bristol-Myers Squibb Company, Bristol-Myers Squibb Company to Women First Healthcare, Inc.
    Inventors: Jingyang Zhu, Scott T. Chadwick, Benjamin A. Price, Shannon X. Zhao, Carrie A. Costello, Purushotham Vemishetti
  • Patent number: 6730809
    Abstract: Provided are processes and synthetic intermediates useful for the preparation of &agr;-difluoromethylornithine (DFMO) having the formula
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: May 4, 2004
    Assignee: Women First Healthcare, Inc.
    Inventors: Jingyang Zhu, Scott T. Chadwick, Benjamin A. Price, Shannon X. Zhao, Carrie A. Costello, Purushotham Vemishetti
  • Publication number: 20030083384
    Abstract: Provided are processes and synthetic intermediates useful for the preparation of &agr;-difluoromethylornithine (DFMO) having the formula 1
    Type: Application
    Filed: August 19, 2002
    Publication date: May 1, 2003
    Applicant: Bristol-Myers Squibb Company to Women First HealthCare, Inc.
    Inventors: Jingyang Zhu, Scott T. Chadwick, Benjamin A. Price, Shannon X. Zhao, Carrie A. Costello, Purushotham Vemishetti
  • Patent number: 6242614
    Abstract: A process for the synthesis of paclitaxel from 10-deacetylbaccatin-III which is protected at the 7-position with a dialkylalkoxysilyl protecting group having the formula —Si(R)2(OR′).
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: June 5, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Purushotham Vemishetti, Francis S. Gibson, John L. Dillon
  • Patent number: 6215000
    Abstract: Disclosed are crystalline complexes of baccatin III with imidazole, 2-methylimidazole or isopropanol, which are useful for isolating baccatin III from plant tissue cell culture and plant extracts containing baccatin Ill.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: April 10, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Francis S. Gibson, Jianmei Wei, John L. Dillon, Jr., Purushotham Vemishetti
  • Patent number: 6008347
    Abstract: The present invention provides novel cis-N-iminomethyl-3,4-disubstituted-2-azetidinones, and their use in the preparation of N-acyl-2-azetidinones, intermediates in the semi-synthesis of taxol and taxol derivatives.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: December 28, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Allan W. Rey, Purushotham Vemishetti, Roberto Droghini
  • Patent number: 5688926
    Abstract: Etoposide phosphate is prepared by coupling dibenzyl 4'-demethyl-4-epipodophyllotoxin-4'-phosphate with 2,3-di-O-benzyl-4,6-O-ethylidene-.alpha.,.beta.-D-glucopyranose in a solvent and subsequently removing the protecting groups. The tetra-benzyl protected etoposide phosphate is recrystallized from methanol or directly crystallized from acetonitrile by adding methanol to yield substantially the pure C-1"-.beta. form. The benzyl protecting groups are simultaneously removed by hydrogenation to produce etoposide phosphate in high yields. In a further embodiment, etoposide phosphate is treated with a phosphatase enzyme to yield etoposide.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 18, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Lee J. Silverberg, Purushotham Vemishetti, John L. Dillon, Jr., John J. Usher