Abstract: The present invention relates to a composition of disease-modifying antirheumatic drugs (DMARDs) for treatment of auto-immune diseases. More particularly, the invention relates to the microemulsion based emulgel composition of DMARD-leflunomide or its derivatives for treatment of auto-immune diseases such as rheumatoid arthritis, atopic dermatitis, psoriasis and skin cancer such as melanoma, squamous cell carcinoma. The invention also discloses a method for preparation of microemulsion based emulgel composition with improved physicochemical, pharmacokinetic properties of leflunomide to be used in pharmaceutical compositions. This invention discloses the delivery of leflunomide across human skin for the treatment of autoimmune and oncological conditions. The unique delivery of leflunomide in the form of microemulsion based emulgel composition is disclosed.

Abstract: Disclosed herein are orally acceptable topical analgesic gels comprising a mixture of herbal oils and extracts comprising (a) clove oil and/or eugenol (e.g., clove leaf oil and/or clove bud oil), (b) a cooling agent (e.g., menthol), (c) camphor, (d) an antimicrobial agent, e.g., turmeric and/or curcumin extract (e.g., turmeric, white turmeric (e.g., white curcumin) and (e) licorice; in an orally acceptable gel base, the gel base comprising one or more nonionic surfactants, the formulation providing a sustained release of the mixture of herbal oils and extracts following application to a tooth or gums; together with methods of making and using the same.

Abstract: Described herein is a powdered soap comprising a plurality of particles, each of the particles comprising: an ionic polymer; and a fatty component comprising compounds having C8 to C18 chains.

Abstract: Described herein is a powdered soap comprising a plurality of particles, each of the particles comprising a polyquat, a clay, and a fatty component.

Abstract: The invention relates to a formulation of Calcium Channel Blocker (CCB) through pulmonary delivery using an inhaler, nebulizer or a similar delivery system against a novel coronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) induced COVID-19 and other respiratory viruses such as influenza, SARS, MERS etc. The formulation comprises verapamil hydrochloride at a concentration between 15 mg/mL and 25 mg/mL, sodium chloride at a concentration of 6.25 mg/mL and distilled water at a volume between q.s. to 1 mL. The formulation is administered as pulmonary delivery through nasal spray. The calcium signaling plays an important role in entry and replication of virus in the host cell and hence targeting the calcium channels or pumps that mediate the mobility of the intracellular calcium is an effective target for SARS-CoV-2 infection.