Patents by Inventor Q. Ping Dou

Q. Ping Dou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyphenol proteasome inhibitors, synthesis, and methods of use
    Patent number: 9399631
    Abstract: The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: July 26, 2016
    Assignees: UNIVERSITY OF SOUTH FLORIDA, MCGILL UNIVERSITY, THE HONG KONG POLYTECHNIC UNIVERSITY
    Inventors: Q. Ping Dou, Tak-Hang Chan, David M. Smith
  • POLYPHENOL PROTEASOME INHIBITORS, SYNTHESIS, AND METHODS OF USE
    Publication number: 20140045931
    Abstract: The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.
    Type: Application
    Filed: October 18, 2013
    Publication date: February 13, 2014
    Applicant: THE HONG KONG POLYTECHNIC UNIVERSITY
    Inventors: Q. PING DOU, TAK-HANG CHAN, DAVID M. SMITH
  • Polyphenol proteasome inhibitors, synthesis, and methods of use
    Patent number: 8563607
    Abstract: The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: October 22, 2013
    Assignees: University of South Florida, McGill University, The Hong Kong Polytechnic University
    Inventors: Q. Ping Dou, Tak-Hang Chan, David M. Smith
  • Gold (III) complexes with oligopeptides functionalized with sulfur donors and use thereof as antitumor agents
    Patent number: 8481496
    Abstract: The invention concerns Au(III) complexes of the type [AuIIIX2(Pdtc)] (X=halogen, pseudo-halogen; pdtc=peptide-/esterified peptidedithiocarbamato) which are able to both maintain the antitumor properties and the lack of nephrotoxic side-effects of the previously reported Au(III)-dithiocarbamato complexes, together with an improved bioavailability through the peptide-mediated cellular internalization. The Au(III) complexes described have shown a significant biological activity on human tumor cell lines and, thus, they can be advantageously used as antineoplastic agents. The preparation method and use for the treatment of tumor pathologies of the Au(III) complexes of the invention are further described.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: July 9, 2013
    Assignees: Universita' Degli Studi di Padova, Centro di Riferimento Oncologico, Wayne State University Board of Govenors
    Inventors: Dolores Fregona, Luca Ronconi, Fernando Formaggio, Q. Ping Dou, Donatella Aldinucci
  • GOLD (III) COMPLEXES WITH OLIGOPEPTIDES FUNCTIONALIZED WITH SULFUR DONORS AND USE THEREOF AS ANTITUMOR AGENTS
    Publication number: 20120101044
    Abstract: The invention concerns Au(III) complexes of the type [AuIIIX2(Pdtc)] (X=halogen, pseudo-halogen; pdtc=peptide-/esterified peptidedithiocarbamato) which are able to both maintain the antitumor properties and the lack of nephrotoxic side-effects of the previously reported Au(III)-dithiocarbamato complexes, together with an improved bioavailability through the peptide-mediated cellular internalization. The Au(III) complexes described have shown a significant biological activity on human tumor cell lines and, thus, they can be advantageously used as antineoplastic agents. The preparation method and use for the treatment of tumor pathologies of the Au(III) complexes of the invention are further described.
    Type: Application
    Filed: March 20, 2009
    Publication date: April 26, 2012
    Inventors: Dolores Fregona, Luca Ronconi, Fernando Formaggio, Q. Ping Dou, Donatella Aldinucci
  • Polyphenol Proteasome Inhibitors, Synthesis, and Methods of Use
    Publication number: 20120029067
    Abstract: The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.
    Type: Application
    Filed: October 11, 2011
    Publication date: February 2, 2012
    Applicants: UNIVERSITY OF SOUTH FLORIDA, THE HONG KONG POLYTECHNIC UNIVERSITY, MCGILL UNIVERSITY
    Inventors: Q. Ping DOU, Tak-Hang CHAN, David M. SMITH
  • Polyphenol proteasome inhibitors, synthesis, and methods of use
    Patent number: 8058310
    Abstract: The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: November 15, 2011
    Assignees: University of South Florida, McGill University, The Hong Kong Polytechnic University
    Inventors: Q. Ping Dou, Tak-Hang Chan, David M. Smith
  • POLYPHENOL COMPOUNDS FOR INHIBITING PROTEASOME AND USES THEREOF
    Publication number: 20110152210
    Abstract: Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for inhibiting proteasomal activity and for treating cancer is also provided.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 23, 2011
    Applicants: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/McGILL UNIVERSITY, THE HONG KONG POLYTECHNIC UNIVERSITY, WAYNE STATE UNIVERSITY
    Inventors: Tak-Hang CHAN, Q. Ping DOU
  • Polyphenol proteasome inhibitors, synthesis, and methods of use
    Patent number: 7767711
    Abstract: The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: August 3, 2010
    Assignees: University of South Florida, McGill University, The Hong Kong Polytechnic University
    Inventors: Q. Ping Dou, Tak-Hang Chan, David M. Smith
  • Polyphenol proteasome inhibitors, synthesis, and methods of use
    Publication number: 20100173985
    Abstract: The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.
    Type: Application
    Filed: February 25, 2010
    Publication date: July 8, 2010
    Applicants: University of South Florida, McGill University, The Hong Kong Polytechnic University
    Inventors: Q. Ping Dou, Tak-Hang Chan, David M. Smith
  • Methods for preventing and treating cancer using -thiolated ?-lactam compounds and analogs thereof
    Patent number: 7635693
    Abstract: The subject invention concerns N-thiolated ?-lactam compounds of formula A, wherein R1 is a hydrocarbon group having 1-8 carbon atoms; R3 is an organothio group; and R4 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl, and analogs and pharmaceutically acceptable salts, esters and amides thereof. The subject invention also concerns methods for inducing tumor cell death or inhibiting tumor cell proliferation, and methods for inducing DNA damage, inhibiting DNA replication, activating p38 MAP kinase, or activating caspase cascade activation, or releasing cytochrome C from mitochondria into the cytoplasm in a tumor cell. Methods for treating cancer using N-thiolated ?-lactam compounds, as well as pharmaceutical compositions comprising the same are further disclosed.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: December 22, 2009
    Assignee: University of South Florida
    Inventors: Q. Ping Dou, Edward Turos, David M. Smith
  • Polyphenol proteasome inhibitors, synthesis, and methods of use
    Patent number: 7358383
    Abstract: The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: April 15, 2008
    Assignees: University of South Florida, McGill University, The Hong Kong Polytechnic University
    Inventors: Q. Ping Dou, Tak-Hang Chan, David M. Smith
  • Methods for preventing and treating cancer using N-thiolated ?-lactam compounds and analogs thereof
    Patent number: 7026472
    Abstract: The subject invention concerns N-thiolated ?-lactam compounds of formula A, wherein R1 is a hydrocarbon group having 1–8 carbon atoms; R3 is an organothio group; and R4 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl, and analogs and pharmaceutically acceptable salts, esters and amides thereof. The subject invention also concerns methods for inducing tumor cell death or inhibiting tumor cell proliferation, and methods for inducing DNA damage, inhibiting DNA replication, activating p38 MAP kinase, or activating caspase cascade activation, or releasing cytochrome C from mitochondria into the cytoplasm in a tumor cell. Methods for treating cancer using N-thiolated ?-lactam compounds, as well as pharmaceutical compositions comprising the same are further disclosed.
    Type: Grant
    Filed: May 6, 2003
    Date of Patent: April 11, 2006
    Assignee: University of South Florida
    Inventors: Q. Ping Dou, Edward Turos, David M. Smith
  • Polyphenol proteasome inhibitors, synthesis, and methods of use
    Publication number: 20040186167
    Abstract: The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.
    Type: Application
    Filed: January 26, 2004
    Publication date: September 23, 2004
    Inventors: Q. Ping Dou, Tak-Hang Chan, David M. Smith
  • Methods for preventing and treating cancer using N-thiolated beta-lactam compounds and analogs thereof
    Publication number: 20040167115
    Abstract: The subject invention concerns N-thiolated &bgr;-lactam compounds, their analogs and pharmaceutically acceptable salts, esters and amides thereof. The subject invention also concerns methods for inducing tumor cell death or inhibiting tumor cell proliferation, and methods for inducing DNA damage, inhibiting DNA replication, activating p38 MAP kinase, or activating caspase cascade activation, or releasing cytochrome C from mitochondria into the cytoplasm in a tumor cell. Methods for treating cancer using N-thiolated &bgr;-lactam compounds, as well as pharmaceutical compositions comprising the same are further disclosed.
    Type: Application
    Filed: May 6, 2003
    Publication date: August 26, 2004
    Inventors: Q. Ping Dou, Edward Turos, David M. Smith
  • Tea polyphenol esters and analogs thereof for cancer prevention and treatment
    Patent number: 6713506
    Abstract: Disclosed herein are ester-bond containing tea polyphenols that has a susceptibility to nucleophilic attack, their analogs and pharmaceutically acceptable salts, method for inhibiting proteasomal chymotrypsin-like activity in vivo and in vitro, methods for cancer treatment with tea-derived polyphenols, such as EGCG, ECG, GCG, or CG, as well as pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: March 30, 2004
    Assignee: University of South Florida
    Inventors: Q. Ping Dou, Sangkil Nam, David M. Smith
  • Tea polyphenol esters and analogs thereof for cancer prevention and treatment
    Publication number: 20020151582
    Abstract: Disclosed herein are ester-bond containing tea polyphenols that has a susceptibility to nucleophilic attack, their analogs and pharmaceutically acceptable salts, method for inhibiting proteasomal chymotrypsin-like activity in vivo and in vitro, methods for cancer treatment with tea-derived polyphenols, such as EGCG, ECG, GCG, or CG, as well as pharmaceutical compositions comprising the same.
    Type: Application
    Filed: October 11, 2001
    Publication date: October 17, 2002
    Inventors: Q. Ping Dou, Sangkil Nam, David M. Smith