Abstract: Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.

Abstract: A container and handle assembly includes a container having a body and an integral neck finish with a pocket and a ledge diametrically spaced from the pocket. A handle has a C-shaped yoke with a first arm having an end hook for receipt in the pocket, and a second arm having an end lug for engaging the ledge on the container body.

Abstract: A container for the packaging of a still beverage or other unpressurized liquid, the container being formed from a thermoplastic material and having a body portion with a closed bottom, a neck portion, tapering inwardly as it extends upwardly from the body portion and a closure, receiving finish portion spaced from the body portion and extending from the neck portion. The container has an integral gripping feature that does not require an opening that extends laterally through the container, the gripping feature being formed by spaced, opposed gripping panels that extend laterally into the container from an edge thereof. In a first embodiment, the container body portion has a generally oval cross-section with a larger, part-circular end, and a smaller part-circular opposed end, with the gripping panels extending into the container in the body portion from the opposed end.

Abstract: Compounds of formula (I) 1

Abstract: The present invention relates to the use of compounds of formula (I) 1

Abstract: The present invention relates to the use of compounds of formula (I) 1

Abstract: Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract: The invention relates to compositions comprising a first fusion protein comprising a first polypeptide domain and a R. reniformis luciferase and a second fusion protein comprising a second polypeptide domain and a R. reniformis GFP. The invention also relates to compositions comprising one or more polynucleotides encoding a first fusion protein comprising a first polypeptide domain and a R. reniformis luciferase and a second fusion protein comprising a second polypeptide domain and a R. reniformis GFP. The invention also relates to methods and kits for detecting protein-protein interactions, determining the location of a protein-protein interaction, identifying cells wherein there is a protein-protein interaction of interest, and screening for a candidate modulator that increases or decreases the amount of a protein-protein interaction.

Abstract: A molded polymeric container that is shaped to be easier to mold, have improved rigidity under pressure and improved strength includes a substantially cylindrical body portion having a longitudinal axis and a circumferential sidewall, and a bottom portion. The bottom portion includes a central pushup area that is substantially symmetrical about the longitudinal axis and that is substantially flat. The pushup area preferably has a radius that is within the range of 0.100 inches to 0.500 inches. The bottom portion further includes a plurality of support feet surrounding and protruding downwardly from the pushup area, each of which has a bottom support surface and a pair of sidewalls that help define a valley between the support feet. The sidewalls have a substantially straight portion that defines an angle with respect to a line that is perpendicular to the longitudinal axis, and this angle is at least 25 degrees.

Abstract: Integrated circuit clock circuitry includes several clock nodes at different locations on a chip. Each node includes a clock wave input, a clock wave output and feedback circuitry for maintaining a predetermined phase relation between clock waves at the clock wave inputs and outputs. The clock wave input of one of the nodes is directly responsive to a clock wave of a clock wave source. A clock coupling circuit connected between each of the clock wave inputs (except the clock wave input of the node directly responsive to the clock wave source) and each of the clock wave outputs couples clock waves from the clock wave output of a first node to a clock wave input of a second node. Each of the coupling circuits includes feedback circuitry for maintaining a predetermined phase relation between clock waves the first node supplies to the coupling circuit and derived by the coupling circuit.

Abstract: Compounds having the formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract: Compounds of formula (I) compounds of formula (II) compounds of formula (III) and compounds of formula (IV) or pharmaceutically acceptable salts thereof are useful as H3 receptor antagonists. Processes to make the compounds and methods of treatment using the compounds are also disclosed.

Abstract: A clock buffer circuit having a reduced propagation delay therethrough. The clock buffer circuit has a clock input for receiving an initial clock pulse thereto, and a clock output for transmitting a buffered clock pulse therethrough. A first driver chain arrangement of transistors is coupled with the clock input and the clock output for switching the buffered clock pulse from a low voltage level to a high voltage level. A second driver chain arrangement of transistors is coupled with the clock input and the clock output for switching the buffered clock pulse from the high voltage level to the low voltage level. A holder circuit and a first and trigger circuit for the second driver chain are also included.

Abstract: Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract: A molded polymeric container that is shaped to be easier to mold, have improved rigidity under pressure and improved strength includes a substantially cylindrical body portion having a longitudinal axis and a circumferential sidewall, and a bottom portion. The bottom portion includes a central pushup area that is substantially symmetrical about the longitudinal axis and that is substantially flat. The pushup area preferably has a radius that is within the range of 0.100 inches to 0.500 inches. The bottom portion further includes a plurality of support feet surrounding and protruding downwardly from the pushup area, each of which has a bottom support surface and a pair of sidewalls that help define a valley between the support feet. The sidewalls have a substantially straight portion that defines an angle with respect to a line that is perpendicular to the longitudinal axis, and this angle is at least 25 degrees.

Abstract: A clock circuit on an integrated circuit chip includes a driver having an output for deriving an output clock wave responsive to a clock wave of a clock wave source, a clock line having a first end coupled to the output of the driver, and a receiver having an input coupled to a second end of the clock line. The receiver has a resistive input impedance causing the clock line carrying the output clock wave to the input of the receiver to present to the driver output an impedance having a resistance-capacitance time constant that is a relatively small fraction of a period of the clock wave.

Abstract: Compounds of formula I: 1

Abstract: Compounds of formula (I) 1

Abstract: A clock buffer circuit having a reduced propagation delay therethrough. The clock buffer circuit has a clock input for receiving an initial clock pulse thereto, and a clock output for transmitting a buffered clock pulse therethrough. A first driver chain arrangement of transistors is coupled with the clock input and the clock output for switching the buffered clock pulse from a low voltage level to a high voltage level. A second driver chain arrangement of transistors is coupled with the clock input and the clock output for switching the buffered clock pulse from the high voltage level to the low voltage level. A holder circuit and a first and trigger circuit for the second driver chain are also included.

Abstract: Clock circuitry on an integrated circuit chip includes a differential buffer with common-mode rejection circuitry. The differential buffer includes first and second DC paths, each including semiconductor devices connected in cascode circuits. A tap of the first path supplies bias voltage to control electrodes of devices of the first and second paths. Control electrodes of devices in the cascode circuits of the first and second paths are connected to be biased by opposite power supply voltages of the buffer.