Abstract: Provided herein is an oven in which a door has a double door structure that includes a first door formed of a transparent material and a second door formed of an opaque material to simultaneously ensure visibility and heat insulation. The oven includes a main body, a cooking compartment provided inside the main body and having an open front surface, a first door rotatably coupled to the main body to open and close the cooking compartment, formed of a transparent material to make an inside of the cooking compartment visible from the outside, and locked to and unlocked from the main body by a locking device, and a second door formed of an opaque material, rotatably coupled to a front surface of the first door, and locked to and unlocked from the first door by the locking device.

Abstract: A refrigerator includes a body, a storage compartment provided in the body, a door to open and close the storage compartment, an icemaker provided to one side of the storage compartment, an ice bucket provided under the icemaker, and a crusher provided to the rear surface of the door and having an inlet disposed under the outlet of the ice bucket when the door is closed. The crusher may be provided separately from the ice bucket and may independently mounted and detached to and from the rear surface of the door. The ice bucket may have a slimmer design. The space utilization and usability of the storage compartments and the rear surface of the doors may be enhanced.

Abstract: Compounds of the form In which Q is selected from —CH?NR12, —W, —CH2NHR13, —CH?O and —CH(OR17)2 capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds.

Abstract: The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.

Abstract: The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.

Abstract: Compounds of the form In which Q is selected from —CH?NR12, —W, —CH2NHR13, —CH?O and —CH(OR17)2 capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds.

Abstract: A refrigerator is provided. The refrigerator includes an insulation structure and fastening structure of an ice-making compartment refrigerant pipe disposed at an inside an ice-making compartment configured to directly supply cooling energy by being in contact with an ice-making tray. The refrigerator includes an insulation member configured to surround the ice-making compartment refrigerant pipe, and a fixing member coupled to an outer circumferential surface of the insulation member in a shape of a loop to prevent the insulation member from being widened.

Abstract: A structure of an ice making compartment of a refrigerator capable of enlarging the volume of a storage compartment by reducing a width of an ice making compartment, and capable of easily discharging the whole ice separately from pieces of ice, the refrigerator including an opening/closing member configured to open and close a portion of a discharge hole and having a cover portion to prevent the whole ice from being discharged in a state that the portion of the discharge hole is closed, the refrigerator including an opening/closing member integrally formed with a fixed blade configured to crush ice in cooperation with a rotary blade.

Abstract: An ice-making unit, which uses a cooling unit in which a refrigerant pipe is received, and a refrigerator having the same. The cooling unit includes a cooler for conduction of coldness, an inner surface of the cooler coming into direct contact with the refrigerant pipe, realizing a direct cooling type ice making operation. A rotatable tray is provided under the cooling unit, so that an ice-separating member attached to the cooling unit pushes ice upon rotation of the tray, allowing the ice to be discharged in a direction opposite to the rotating direction of the tray.

Abstract: Compounds of the form In which Q is selected from —CH?NR12, —W, —CH2NHR13, —CH?O and —CH(OR17)2 capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds.

Abstract: A structure of an ice making compartment of a refrigerator capable of enlarging the volume of a storage compartment by reducing a width of an ice making compartment, and capable of easily discharging the whole ice separately from pieces of ice, the refrigerator including an opening/closing member configured to open and close a portion of a discharge hole and having a cover portion to prevent the whole ice from being discharged in a state that the portion of the discharge hole is closed, the refrigerator including an opening/closing member integrally formed with a fixed blade configured to crush ice in cooperation with a rotary blade.

Abstract: The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.

Abstract: Compounds of the form In which Q is selected from —CH?NR12, —W, —CH2NHR13, —CH?O and —CH(OR17)2 capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds.

Abstract: The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.

Abstract: A refrigerator includes a body, a storage compartment provided in the body, a door to open and close the storage compartment, an icemaker provided to one side of the storage compartment, an ice bucket provided under the icemaker, and a crusher provided to the rear surface of the door and having an inlet disposed under the outlet of the ice bucket when the door is closed. The crusher may be provided separately from the ice bucket and may independently mounted and detached to and from the rear surface of the door. The ice bucket may have a slimmer design. The space utilization and usability of the storage compartments and the rear surface of the doors may be enhanced.

Abstract: A refrigerator is provided. The refrigerator includes an insulation structure and fastening structure of an ice-making compartment refrigerant pipe disposed at an inside an ice-making compartment configured to directly supply cooling energy by being in contact with an ice-making tray. The refrigerator includes an insulation member configured to surround the ice-making compartment refrigerant pipe, and a fixing member coupled to an outer circumferential surface of the insulation member in a shape of a loop to prevent the insulation member from being widened.

Abstract: Disclosed herein are an ice maker and a refrigerator having the same. The ice maker includes an ice making tray including a plurality of ice making cells, a driving unit to rotate the ice making tray, a plurality of blades corresponding to the plurality of ice making cells to block the ice cubes made in the ice making cells and thus twist the ice making tray while removing the ice cubes from the ice making cells when the ice making tray is rotated, and a protrusion formed on the ice making tray to assist the removal of the ice cubes from the ice making cells. The ice maker removes the ice cubes from the ice making tray by a twisting-type deicing process using the plurality of blades and the protrusion.

Abstract: Disclosed herein are an ice-making unit, which uses a cooling unit in which a refrigerant pipe is received, and a refrigerator having the same. The cooling unit includes a cooler for conduction of coldness, an inner surface of the cooler coming into direct contact with the refrigerant pipe, realizing a direct cooling type ice making operation. A rotatable tray is provided under the cooling unit, so that an ice-separating member attached to the cooling unit pushes ice upon rotation of the tray, allowing the ice to be discharged in a direction opposite to the rotating direction of the tray.

Abstract: Compounds with antiplatelet aggregation and anticoagulant characteristics for the treatment of cardiovascular, cerebrovascular, and cardiovascular related diseases and symptoms, are described. The methods are directed to administering pharmaceutical compositions comprising aryl sulfonic pyridoxine and/or substituted pyridoxine analogs.

Abstract: A process for the purification of paclitaxel and/or cephalomannine and/or 10-DAB III and/or 9-DHAB III is described. A series of extractions, separations, and purifications provides these products in commercial quantities with high purity. The source for these natural products is from readily available renewable biomaterials, such as leaves and stems from the yew, T. canadensis.