Abstract: Methods and compositions capable of modulating activity of TLX (NR2E1), a nuclear receptor essential for neural stem cell self-renewal are provided. The modulations may comprise downregulating TLX expression and/or modulating TET3. In addition, methods of delivering shRNAs using dendrimer nanoparticles into glioblastoma stem cells are provided. The methods and compositions are useful for treating and preventing the progression of brain cancer, e.g. glioblastoma.

Abstract: Embodiments of the present disclosure relate to the field of network technologies, including a resource transfer method and apparatus and a storage medium. The method includes: storing a graphic code in the specified application client, the graphic code being sent by a specified server when a network is already connected, the graphic code including a user identifier used by the specified application client to log in to the specified server, and the graphic code being obtained by the specified server from a third-party server accessed by an interface of the specified server, and presenting a stored graphic code when detecting a graphic code calling operation.

Abstract: The present invention relates to the technical field of pesticides, particularly relates to a pyrazole compound or a salt thereof, a preparation method therefor, a herbicidal composition and use thereof. A pyrazole compound of formula (I) or a salt thereof: wherein, R1 represents hydrogen or C1-C4 alkyl; R2 represents C1-C3 alkyl; R3 represents C1-C6 linear chain or cyclic group containing one or more heteroatoms selected from O, S, and N; R4 represents C1-C3 alkyl or halogen; R5 represents pyrazole ring or pyrazole ring substituted with one or more groups selected from alkyl, alkoxyl, halogen, halogenated alkyl, amino, and nitro. The pyrazole compound is an excellent herbicide with broad spectrum biological activity and outstanding safety for crops.

Abstract: A cornfield herbicidal composition comprising pyrazolone compounds and an application thereof is provided. The cornfield herbicidal composition comprises an herbicidally effective amount of an active ingredient A, an active ingredient B, and a safener compound C, wherein the active ingredient A is a compound of the formula (I); the active ingredient B is selected from one or more of the following compounds: triazines, nitriles, sulfonylureas, pyridine carboxylic acids, benzyl carboxylic acids, bentazone, amides, pyridines and amicarbazone; and the safener compound C is selected from one or more of the following compounds: C1 isoxadifen-ethyl, C2 cyprosulfamide, C3 mefenpyr-diethyl, C4 cloquintocet-mexyl, C5 gibberellic acid, C6 furilazole and C7 N-(2-methoxybenzoyl)-4-[(methylaminocarbonyl)amino]benzenesulfonamide.

Abstract: Methods and compositions capable of modulating activity of TLX (NR2E1), a nuclear receptor essential for neural stem cell self-renewal are provided. The modulations may comprise downregulating TLX expression and/or modulating TET3. In addition, methods of delivering shRNAs using dendrimer nanoparticles into glioblastoma stem cells are provided. The methods and compositions are useful for treating and preventing the progression of brain cancer, e.g. glioblastoma.

Abstract: The present invention relates to the technical field of pesticides, particularly relates to a pyrazole compound or a salt thereof, a preparation method therefor, a herbicidal composition and use thereof. A pyrazole compound of formula (I) or a salt thereof: wherein, R1 represents hydrogen or C1-C4 alkyl; R2 represents C1-C3 alkyl; R3 represents C1-C6 linear chain or cyclic group containing one or more heteroatoms selected from O, S, and N; R4 represents C1-C3 alkyl or halogen; R5 represents pyrazole ring or pyrazole ring substituted with one or more groups selected from alkyl, alkoxyl, halogen, halogenated alkyl, amino, and nitro. The pyrazole compound is an excellent herbicide with broad spectrum biological activity and outstanding safety for crops.

Abstract: Disclosed are a pyrazole compound or a salt thereof, a preparation method therefor, a herbicidal composition and use thereof. The pyrazole compound or a salt thereof has a structure as shown in formula (I): wherein, R represents wherein, R?, R?, and R?? represent hydrogen, C1-C4 alkyl, C1-C4 halogenated alkyl, C1-C4 alkoxy or halogen, R?, R?, and R?? may be the same or different; R1 represents C1-C3 alkyl; R2 represents hydrogen or C1-C4 alkyl; R3 represents hydrogen or C1-C6 alkyl, optionally substituted phenyl, optionally substituted pyridyl, optionally substituted alkenyl, optionally substituted alkynyl, C1-C6 alkyl carbonyl, C1-C6 alkoxyl carbonyl, C1-C6 alkyl carbonyl methyl, etc. A compound having a pyrazole structure not only has excellent herbicidal effect on barnyard grass, but also is safe to rice in post-emergence application. More surprisingly, it also has good control efficacy on barnyard grass resistant to major herbicides, such as penoxsulam, quinclorac, cyhalofop-butyl, propanil, etc.

Abstract: The present invention belongs to the field of pesticides, particularly relates to a pyrazolone compound or a salt thereof, a preparation method therefor, a herbicidal composition and use thereof. The pyrazolone compound is as described in formula I: In the formula, R1R2N represents substituted or unsubstituted 3-8 membered nitrogen-containing heterocyclic group containing 1-3 heteroatoms; or R1 and R2 each represent hydrogen or C1-8 alkyl; R3 represents hydrogen, C1-4 alkyl, alkenyl, alkynyl, unsubstituted C3-6 cycloalkyl or C3-6 cycloalkyl substituted by C1-4 alkyl; R4 represents methyl, ethyl, n-propyl, isopropyl or cyclopropyl; X represents hydrogen, —S(O)nR6, —R7 or substituted or unsubstituted 3-8 membered heterocyclic group containing 1-4 heteroatoms, wherein, n represents 1, 2 or 3, R6 represents substituted or unsubstituted alkyl or aryl, and R7 represents substituted or unsubstituted alkyl, aryl, alkyl acyl or aroyl.

Abstract: The high accuracy pulse duty-cycle calculation hardware implementation scheme is composed of a clock generator block, digital pulse width account block, digital memory block to store pulse width in digital and digital-analog divider block with two digital-analog converters. The digital pulse width account block is used to account the two pulse width of a pulse, e.g. turn-on time TON, turn-off time TOFF, cycle time TS or other time variable in digital method. The digital memory block is used to store digital information from the digital pulse width account block until next cycle.

Abstract: The constant switching frequency discontinuous current mode average output current control scheme is composed of a reference block, reference calculation block, state detecting block, error detector block, zero state detector, power driver block and internal clock.

Abstract: A movement of an elevator cage is detected by an elevator control on the basis of signals of a rotary encoder, coupled with a rotational movement of the drive motor or the drive pulley. Before movement of the cage begins, a movement plot in the form of a trip/speed profile is calculated for travel of the elevator cage from an instantaneous elevator cage position to a destination stopping point position. An anticipated slip between the drive pulley and a support means is included in the calculation of the trip/speed profile, and during the travel of the elevator cage a rotational movement of the drive motor and thus of the drive pulley is controlled by the elevator control in dependence on the calculated trip/speed profile and on signals of the rotary encoder.

Abstract: In order to keep the advantage of PWM dimming control scheme and make the LED driver high reliability and the LED lamp long lifetime, it is required that the frequency of PWM dimming control scheme is related with or the same as the output frequency of existed dimmers; and the output PWM dimming pulse is covered by the output pulse from dimmers further. The present invention discloses a novel “LED dimming control” scheme to make that the frequency of PWM dimming control scheme is related with or the same as the output frequency of dimmers; and the output PWM dimming pulse is covered by the output pulse from the dimmers further. In this way, it can guarantee that as PWM dimming pulse comes, the output from the dimmer can offer enough power to the LED driver and the LED driver can output the required LED driving current without flicker.

Abstract: A switching adapter control method for adaptive mobile power systems is composed of reference current generator, current mode error compensator, controllable constant turn-off timer, PWM generator and MOSFET driver. The output of the switching adapter can show constant current and voltage characteristics, that means, as the DC bus voltage is over a preset voltage, the adaptor's output characteristic is converted from a constant current source into a constant voltage source with the preset voltage. For low output capacitance case, the present invention has the ability to smoothly reduce the switching frequency of the switching adaptor and reduce the switching losses and meet Energy Star 2.0 requirements under different load conditions. And the output ripple current and voltage can be in the allowed range.

Abstract: In order to keep the advantage of PWM dimming control scheme and make the LED driver high reliability and the LED lamp long lifetime, it is required that the frequency of PWM dimming control scheme is related with or the same as the output frequency of existed dimmers; and the output PWM dimming pulse is covered by the output pulse from dimmers further. The present invention discloses a novel “LED dimming control” scheme to make that the frequency of PWM dimming control scheme is related with or the same as the output frequency of dimmers; and the output PWM dimming pulse is covered by the output pulse from the dimmers further. In this way, it can guarantee that as PWM dimming pulse comes, the output from the dimmer can offer enough power to the LED driver and the LED driver can output the required LED driving current without flicker.

Abstract: A movement of an elevator cage is detected by an elevator control on the basis of signals of a rotary encoder, coupled with a rotational movement of the drive motor or the drive pulley. Before movement of the cage begins, a movement plot in the form of a trip/speed profile is calculated for travel of the elevator cage from an instantaneous elevator cage position to a destination stopping point position. An anticipated slip between the drive pulley and a support means is included in the calculation of the trip/speed profile, and during the travel of the elevator cage a rotational movement of the drive motor and thus of the drive pulley is controlled by the elevator control in dependence on the calculated trip/speed profile and on signals of the rotary encoder.

Abstract: High accuracy average output current control scheme for power current converter in critical DCM is composed of the reference block to generate preset reference; the reference calculation block, based on the power current converter's power topology, the correspondent algorithm is calculated to convert the input reference into correspondent output; the state detecting block, the states of power current converter are detected and the detected signals are converted into the same signal format as one of output from reference calculation block; the error detector is used to detect the error between the outputs from reference calculation block and state detected block and to trigger power driver block to turn off the power switch in the power current converter as the error is cross over zero; the zero state detector is used to detect when the states of the power current converter are cross over zero and trigger power driver block to turn on the power switch in the power current converter; the power driver block is c

Abstract: A switching adapter control method for adaptive mobile power systems is composed of reference current generator, current mode error compensator, controllable constant turn-off timer, PWM generator and MOSFET driver. The output of the switching adapter can show constant current and voltage characteristics, that means, as the DC bus voltage is over a preset voltage, the adaptor's output characteristic is converted from a constant current source into a constant voltage source with the preset voltage. For low output capacitance case, the present invention has the ability to smoothly reduce the switching frequency of the switching adaptor and reduce the switching losses and meet Energy Star 2.0 requirements under different load conditions. And the output ripple current and voltage can be in the allowed range.

Abstract: The isolated current regulated DC-DC converter is composed of the step down switch SA, free wheel diode DA, step down inductor L, switches S1 and S2, capacitor Cc to absorb the leakage energy of the switching transformer, output diodes D3 and D4, output filter capacitor C and the switching transformer T; one terminal of the step down inductor L is connected with the step down switch SA and free wheel diode DA, and other terminal of the step down inductor L is connected with one of primary windings of the switching transformer and switch S1 or S2; two primary windings of the switching transformer are respectively connected with switches S1 and S2 in series; two primary winding and switch S1 or S2 branches are paralleled and respectively connected with the free wheel diode DA and the step down inductor L; the free wheel diode DA is series with the step down switch SA and they connect with the input voltage Vin; the capacitor Cc to absorb the leakage energy of the switching transformer is respectively connected

Abstract: The invention presents a simple and high accuracy output current detect and control scheme to control the output current of the step up-down (Buck-Boost) and step up (Boost) switching converter, It makes step up-down (Buck-Boost) and step up (Boost) switching power converter operate in wide input voltage range and low in total BOM cost and the switching converter can be used as a controllable current source for several applications

Abstract: High accuracy average output current control scheme for power current converter in critical DCM is composed of the reference block to generate preset reference; the reference calculation block, based on the power current converter's power topology, the correspondent algorithm is calculated to convert the input reference into correspondent output; the state detecting block, the states of power current converter are detected and the detected signals are converted into the same signal format as one of output from reference calculation block; the error detector is used to detect the error between the outputs from reference calculation block and state detected block and to trigger power driver block to turn off the power switch in the power current converter as the error is cross over zero; the zero state detector is used to detect when the states of the power current converter are cross over zero and trigger power driver block to turn on the power switch in the power current converter; the power driver block is c