Abstract: Provided herein are Bridged Compounds having the following structures: wherein R1a, R1b, R1c, R1d, R2a, R2b, R2c, R2d, R3a, R3b, R3c, R3d, R4, R5, R6, R7, R8, m1, m2, m3, n2, n3, n4, q, X1, X2, Y1, Y2, L1 and ring A are as defined herein, compositions comprising an effective amount of a Bridged Compound, and methods for treating or preventing various diseases, e.g., pancreatic cancer, or a condition treatable or preventable by inhibition of the function of KRAS protein. In another aspect, a Bridged Compound is useful for treating or preventing a condition treatable or preventable by inhibition of the function of KRAS protein with G12D mutation. In another aspect, a Bridged Compound is useful for treating or preventing a condition treatable or preventable by inhibition of a RAS/MAPK pathway.

Abstract: A sampling device and method for evaluating ecological risk of soil in a high geological background area comprises an impact sampling mechanism, a soil layer stripping mechanism and an auxiliary support frame. The impact sampling mechanism comprises a sampling hopper with a downward opening. A connecting sliding rod is fixedly arranged on the top of the sampling hopper. An upper end of the connecting sliding rod is connected with an impact rod. The impact rod is internally provided with an impact hammer capable of reciprocating along an axis of the impact rod. The soil layer stripping mechanism comprises a stripping sliding cylinder in sliding fit with the connecting sliding rod, and a support disc. A plurality of stripping plates are connected to a lower side edge of the support disc in a sliding fit mode.

Abstract: Methods, systems and computer devices are provided for adjusting a frame-listening cycle. The method includes: configuring, by a server, a fixed frame-listening cycle of an electronic shelf label according to a time period; and sending, by the server, a second frame-listening cycle modification command through a base station when the server is to issue the fast response service during the low power consumption time period, so that the electronic shelf label modifies the current frame-listening cycle to a fast frame-listening cycle according to the second frame-listening cycle modification command. According to the present disclosure, the electronic shelf label can not only respond to the fast response service in real time, but also keep the low power consumption of a long frame-listening cycle, thereby simultaneously satisfying the requirements of high real-time performance and low power consumption of the electronic shelf label.

Abstract: A sampling device and method for evaluating ecological risk of soil in a high geological background area comprises an impact sampling mechanism, a soil layer stripping mechanism and an auxiliary support frame. The impact sampling mechanism comprises a sampling hopper with a downward opening. A connecting sliding rod is fixedly arranged on the top of the sampling hopper. An upper end of the connecting sliding rod is connected with an impact rod. The impact rod is internally provided with an impact hammer capable of reciprocating along an axis of the impact rod. The soil layer stripping mechanism comprises a stripping sliding cylinder in sliding fit with the connecting sliding rod, and a support disc. A plurality of stripping plates are connected to a lower side edge of the support disc in a sliding fit mode.

Abstract: A shelf label system and a method thereof are provided. The shelf label system includes base stations and at least one server. The at least one server may be configured to: obtain a target network topological structure according to a master base station having a shallowest topological depth and a ranging result between a base station and a superior base station of the base station, where each base station has a single superior base station; generate a transceiving time slot periodic table by allocating a transceiving time slot to each base station according to the target network topological structure; and obtain a synchronous network of the shelf label system by instructing the base stations to transmit and receive synchronous signals according to the transceiving time slot periodic table. The shelf label system further includes electronic shelf labels that receive the synchronous signals from the base stations.

Abstract: The disclosure herein provides bridged compounds as well as their compositions and methods of use. The compounds disclosed herein inhibit KRAS G12D activity and are useful in the treatment of various diseases including cancer.

Abstract: A positive active material comprising active material bulk particles and a coating layer of an oxide containing N element is disclosed, wherein the surface of the active material bulk particle is doped with M element to form a doped layer, and the content of the M element is 400 ppm to 3000 ppm, and the content of the M element gradually decreases from the outer surface of active material bulk particles towards the core direction; wherein the content of the N element in the coating layer is 100 ppm to 2000 ppm; wherein the average content of the N element per unit volume of the coating layer is greater than the average content of the M element per unit volume of the doped layer; wherein the M element and the N element are each independently selected from one or more of Mg, Ca, Ce, Ti, Zr, Al, Zn, and B.

Abstract: Aspects of the invention include detecting an error alert from a target computer system. In response to detecting the error alert, performance data is then retrieved from the target computer system. A gated recurrent unit (GRU) neural network is used to generate a prediction of a root cause of the error alert based on the performance data. The weights of a reset gate of the GRU neural network are adjusted based on received feedback of the prediction.

Abstract: A dynamic frequency allocation method for base stations, a shelf label system and a computer device are provided. The method includes: obtaining a current connectivity structure of base stations; obtaining a current weight degree of each base station based on a frequency interval weight between base stations in the current connectivity structure; performing priority classification on all current base stations to obtain a current priority type of each base station; and obtaining a current allocated frequency of each base station based on the current priority type of the base station, the current weight degree of the base station, the frequency interval weight and a current available frequency set.

Abstract: Aspects of this technical solution can include identifying, by a wireless communication device, various of a plurality of data units each respectively corresponding to various types of communication, determining, by the wireless communication device and from various of the plurality of data units, various parameters each indicating an importance of respective ones of the plurality of data units according to the various types of communication, selecting, by the wireless communication device according to various of the parameters satisfying a first heuristic indicative of a type of communication among the types of communication, various selected data units among various of the plurality of data units that correspond to the parameters satisfying a second heuristic corresponding to a quality-of-service (QoS) level for the type of communication, and transmitting, by the wireless communication device according to the second heuristic, various of the selected data units.

Abstract: Methods, systems and computer devices are provided for adjusting a frame-listening cycle. The method includes: configuring, by a server, a fixed frame-listening cycle of an electronic shelf label according to a time period; and sending, by the server, a second frame-listening cycle modification command through a base station when the server is to issue the fast response service during the low power consumption time period, so that the electronic shelf label modifies the current frame-listening cycle to a fast frame-listening cycle according to the second frame-listening cycle modification command. According to the present disclosure, the electronic shelf label can not only respond to the fast response service in real time, but also keep the low power consumption of a long frame-listening cycle, thereby simultaneously satisfying the requirements of high real-time performance and low power consumption of the electronic shelf label.

Abstract: The present invention belongs to the field of medicine, and specifically discloses an amino alcohol derivative represented by Formula I, a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof. In addition, the present invention also discloses a pharmaceutical composition comprising the above substances, and a use of the substance in the preparation of a medicament for the prevention and treatment of an immune inflammatory disease, or a disease or condition associated with immunological competence such as multiple sclerosis, ALS, CIDP, systemic lupus erythematosus, rheumatoid arthritis, ulcerative colitis, psoriasis, polymyositis, etc.

Abstract: Aspects of the invention include detecting an error alert from a target computer system. In response to detecting the error alert, performance data is then retrieved from the target computer system. A gated recurrent unit (GRU) neural network is used to generate a prediction of a root cause of the error alert based on the performance data. The weights of a reset gate of the GRU neural network are adjusted based on received feedback of the prediction.

Abstract: Disclosed herein are compounds that inhibit KRas G12C, pharmaceutical compositions, methods of preparation and uses thereof.

Abstract: The present invention belongs to the field of medicine, and specifically discloses an amino alcohol derivative represented by Formula I, a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof. In addition, the present invention also discloses a pharmaceutical composition comprising the above substances, and a use of the substance in the preparation of a medicament for the prevention and treatment of an immune inflammatory disease, or a disease or condition associated with immunological competence such as multiple sclerosis, ALS, CIDP, systemic lupus erythematosus, rheumatoid arthritis, ulcerative colitis, psoriasis, polymyositis, etc.

Abstract: The present invention relates to the crystal form of imidazolone type compounds, and a preparation method, pharmaceutical composition and use thereof, and falls within the field of pharmaceutical compound crystals. The crystal form provided by the present invention has a good stability, comprising good stability under the three extreme conditions of high temperature, high humidity and strong illumination, and can also maintain a good stability during the tablet compressing process. The crystal form provided by the present invention has good absorption and metabolism properties in vivo, comprising the drug concentration of blood, the drug concentration-time curve AUC, the half-life period, etc. In addition, the dissolving rate of the crystal form of the present invention is improved, wherein same is beneficial for the applications thereof in preparations.

Abstract: The present invention relates to the crystal form of imidazolone type compounds, and a preparation method, pharmaceutical composition and use thereof, and falls within the field of pharmaceutical compound crystals. The crystal form provided by the present invention has a good stability, comprising good stability under the three extreme conditions of high temperature, high humidity and strong illumination, and can also maintain a good stability during the tablet compressing process. The crystal form provided by the present invention has good absorption and metabolism properties in vivo, comprising the drug concentration of blood, the drug concentration-time curve AUC, the half-life period, etc. In addition, the dissolving rate of the crystal form of the present invention is improved, wherein same is beneficial for the applications thereof in preparations.

Abstract: This application relates to imidazolone compounds, pharmaceutically acceptable salts, solvents, polymorphs or prodrugs thereof, and further relates to pharmaceutical combinations comprising the foregoing substances and uses for preventing and treating protein kinase related diseases such as cancer, metabolic diseases, and cardiovascular diseases.

Abstract: A network system for positioning services based on wireless communication system, including base stations, a dedicated access apparatus, cables, and a server. The base stations, the dedicated access apparatus and the cables constituting a private network. The server constituting a public network. The base stations are configured to send and receive signals in a broadcasting manner, and transmit the signals to the server through the cables and the dedicated access apparatus. The dedicated access apparatus is configured to transfer transmission data between the private network and the public network, forward data from the base stations to the server, and forward data from the server to a corresponding base station. The cables are configured to transmit data between the base stations and between the base stations and the dedicated access apparatus. The server is configured to perform data processing according to the received data collected by at least one base station.

Abstract: A network system for positioning services based on wireless communication system, including base stations, a dedicated access apparatus, cables, and a server. The base stations, the dedicated access apparatus and the cables constituting a private network. The server constituting a public network. The base stations are configured to send and receive signals in a broadcasting manner, and transmit the signals to the server through the cables and the dedicated access apparatus. The dedicated access apparatus is configured to transfer transmission data between the private network and the public network, forward data from the base stations to the server, and forward data from the server to a corresponding base station. The cables are configured to transmit data between the base stations and between the base stations and the dedicated access apparatus. The server is configured to perform data processing according to the received data collected by at least one base station.