Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitDynaivity to antigens.

Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens.

Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens.

Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens.

Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens.

Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens.

Abstract: An exemplary multi-function portable electronic device includes a housing, a measurement processing unit, a microprocessor unit electrically connected to the measurement processing unit and a command unit. The measurement processing unit and the microprocessor unit are located in the housing, and the command unit is located in the housing and electrically connected to microprocessor unit. The command unit is used to start a multimeter mode of the portable electronic device, select a measurement project and measurement range of the measurement project. Under the control of the microprocessor, the measurement processing unit receives and processes the measurement project in accordance with the measurement range, and sends measurement results to the microprocessor.

Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens.

Abstract: A vehicle light can include a plurality of light projection units each having a replaceable LED lamp, a reflector unit, a projection lens, and a shielding member. A housing can be provided that includes a lens and a rear side part, with the housing configured to accommodate the light projection units. The rear side part can include a mounting opening therethrough with a base plate configured to be hermetically attached to the housing through the mounting opening of the rear side part. The replaceable LED lamp can be attached to the base plate, and an elastic connecting member can be configured to hermetically connect the housing and the base plate so that the LED lamps can be individually replaced. Since the LED lamps can be individually replaced, untrained persons can carry out the replacement operation. Furthermore, it is possible to reduce the replacement cost and time as well as improve the rate of operation of a vehicle.

Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens.

Abstract: An IC socket (1) includes a base (2), a cover (5) slidably engaged upon the base, and a lever (4) for driving the cover to slide on the base. The lever includes a lateral rod (41) and a longitudinal rod (42) connected to the lateral rod. The lateral rod is received in between the cover and the base. The longitudinal rod is exposed out of the cover and the base, with a connecting section (421) of the longitudinal rod parallel to one side face of the cover, and an acting section (423) joined to the connecting section and configured to be laterally tilted towards the one side face of the cover. Thus, this configuration of the acting section of the longitudinal rod will occupy less room on a printed circuit board, and enables the lever to be engagably retained on the cover side face so as to prevent the lever from being removed by accidental touching or vibration.

Abstract: A vehicle light can include a plurality of light projection units each having a replaceable LED lamp, a reflector unit, a projection lens, and a shielding member. A housing can be provided that includes a lens and a rear side part, with the housing configured to accommodate the light projection units. The rear side part can include a mounting opening therethrough with a base plate configured to be hermetically attached to the housing through the mounting opening of the rear side part. The replaceable LED lamp can be attached to the base plate, and an elastic connecting member can be configured to hermetically connect the housing and the base plate so that the LED lamps can be individually replaced. Since the LED lamps can be individually replaced, untrained persons can carry out the replacement operation. Furthermore, it is possible to reduce the replacement cost and time as well as improve the rate of operation of a vehicle.

Abstract: An IC socket (1) includes a base (2), a cover (5) slidably engaged upon the base, and a lever (4) for driving the cover to slide on the base. The lever includes a lateral rod (41) and a longitudinal rod (42) connected to the lateral rod. The lateral rod is received in between the cover and the base. The longitudinal rod is exposed out of the cover and the base, with a connecting section (421) of the longitudinal rod parallel to one side face of the cover, and an acting section (423) joined to the connecting section and configured to be laterally tilted towards the one side face of the cover. Thus, this configuration of the acting section of the longitudinal rod will occupy less room on a printed circuit board, and enables the lever to be engagably retained on the cover side face so as to prevent the lever from being removed by accidental touching or vibration.