Abstract: The present invention relates to a use of polypeptide compounds having dual agonist effect on glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR). The polypeptide compounds are characterized by high enzymolysis stability, high potency and no adverse reaction, and capable of substantially improving hepatic fibrosis caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) and severity of fibrotic conditions accompanied with liver diseases. The dual target agonist polypeptide derivatives are capable of preventing or treating hepatic fibrosis diseases associated with viral hepatitis.

Abstract: Provided are an ingot growth device and growth method. The ingot growth device includes a furnace body, a crucible, a cooling jacket and a reflector, wherein the cooling jacket is arranged inside the furnace body to cool the ingot, the reflector is arranged on a periphery of the cooling jacket, the reflector includes an upper reflector part and a lower reflector part, the upper reflector part is cylindrical and surrounds the cooling jacket, the lower reflector part is arranged at a lower end of the upper reflector part and is located on a lower side of the cooling jacket, the lower reflector part is of a hollow circular truncated cone structure with a large top and a small bottom, a groove is formed on an inner peripheral wall of the circular truncated cone structure, the top of the groove penetrates through the circular truncated cone structure.

Abstract: Provided herein, in certain embodiments, are programmable nucleases, guide nucleic acids, and complexes thereof. Certain programmable nucleases provided herein comprise a RuvC domain. Also provided herein are nucleic acids encoding said programmable nucleases and guide nucleic acids. Also provided herein are methods of genome editing, methods of regulating gene expression, and methods of detecting nucleic acids with said programmable nucleases and guide nucleic acids.

Abstract: A high flux antibacterial polyacrylonitrile-based uranium-extraction-from-seawater-seawater desalination cogeneration membrane and a preparation method thereof are disclosed. To satisfy demand of uranium-extraction-from-seawater-seawater desalination cogeneration application, polyacrylonitrile, chitosan and amidoxime modified polyacrylonitrile are taken as raw materials and a proportion of raw materials of a casting membrane are optimized in a membrane forming process. The conversion rate of polyacrylonitrile is adjusted so that formation of an amidoxime modified polyacrylonitrile powder in a casting membrane liquid mixing system is regulated and controlled, thereby significantly improving the mechanical properties, the flux, the hydrophilicity, the antibacterial property and the uranium adsorptive property.

Abstract: Presented are methods of assessing a deficit in DNA damage repair capability in cancer cells. Cancer cells having this DNA damage repair phenotype have increased susceptibility to certain treatments, including genotoxic treatments, treatment with PARP1 inhibitors, and immunotherapies. The methods encompass the use of novel gene expression signatures that enable facile and rapid determination of the DNA damage repair phenotype in cancer cells of a sample. By these methods, subjects having cancer that is amenable to genotoxic treatment, PARP1 inhibition, or immunotherapy may be identified and administered a suitable treatment. Also disclosed is a method of inducing the DNA damage repair deficit phenotype in cancer cells to sensitize them to various treatments.

Abstract: A point cloud encoding and decoding method and a point cloud decoder are provided in the disclosure. The point cloud encoding includes the following. Geometry information and attribute information of points in a point cloud are obtained. Prediction values of the attribute information of the points in the point cloud are determined according to the geometry information of the points in the point cloud. Residual values of the attribute information of the points in the point cloud are determined according to the prediction values of the attribute information of the points in the point cloud. The residual values of the attribute information of the points in the point cloud are processed with a first encoding process, where lossless encoding is performed on a residual value of attribute information of at least one point in the point cloud in the first encoding process.

Abstract: A high flux antibacterial polyacrylonitrile-based uranium-extraction-from-seawater-seawater desalination cogeneration membrane and a preparation method thereof are disclosed. To satisfy demand of uranium-extraction-from-seawater-seawater desalination cogeneration application, polyacrylonitrile, chitosan and amidoxime modified polyacrylonitrile are taken as raw materials and a proportion of raw materials of a casting membrane are optimized in a membrane forming process. The conversion rate of polyacrylonitrile is adjusted so that formation of an amidoxime modified polyacrylonitrile powder in a casting membrane liquid mixing system is regulated and controlled, thereby significantly improving the mechanical properties, the flux, the hydrophilicity, the antibacterial property and the uranium adsorptive property.

Abstract: A method of growing the ingot, including following steps: S1, providing an initial charge into a crucible; S2, heating the crucible to melt the initial charge, and after a set time, rotating the crucible at a rotation speed within a set speed range; S3, after a melting process of the charge is completed, descending a feed device to the position above the melt level in the crucible and a distance between feed device and the melt level being h, the feed device including a feed tube, and the feed tube adding a charge into a feed zone of the crucible; and S4, feeding in the feed zone, and growing an ingot in a growth zone.

Abstract: A polypyrrole-coated graphene corrosion inhibitor container and its preparation method and a composite coating and its application are provided. The polypyrrole encapsulated graphene corrosion inhibitor container includes graphene oxide and a polyvinylo layer encapsulated on the surface of the graphene oxide. The invention is based on a polymerization reaction by mixing a polypyrrole acid solution, a graphene oxide dispersion, and an initiator to obtain a polypyrrole encapsulated graphene corrosion inhibitor container. The polypyrrole encapsulated graphene corrosion inhibitor container regulates the release rate of the corrosion inhibitor by wrapping the polypyrrole around the graphene oxide so that it is released rapidly in alkaline solutions and at a slower rate in neutral media.

Abstract: A display panel includes a display substrate and a cover plate connected through an optical adhesive layer. The display substrate includes a plurality of light emitting elements, a pixel defining layer, and an encapsulation layer; the encapsulation layer includes a first inorganic encapsulation layer, a first organic encapsulation layer, and a second inorganic encapsulation layer; the display panel includes a display region and a frame region including a cutting region and a dam glue region where a dam glue is located; at least one of a plurality of cover plate alignment marks is between the dam glue and the display region and is overlapped with the second inorganic encapsulation layer, and at least one of the plurality of cover plate alignment marks is between the dam glue and the cutting region.

Abstract: Provided are an organic electroluminescent device and a full-color display thereof. The organic electroluminescent device is a top-emitting device. Since an organic luminescent dopant material having a narrow full width at half maximum and a specific maximum emission wavelength is included in the organic layer, when the maximum current efficiency is reached, the color coordinates corresponding to the organic electroluminescent device satisfy: 0.165?CIEx?0.175, and 0.770?CIEy?0.800. The organic electroluminescent device enables a full-color display that includes the device to have a higher coverage of BT.2020. Further provided is a full-color display.

Abstract: The disclosure provides a spintronic device, a SOT-MRAM storage cell, a storage array and a in-memory computing circuit. The spintronic device includes a ferroelectric/ferromagnetic heterostructure, a magnetic tunnel junction, and a heavy metal layer between the ferroelectric/ferromagnetic heterostructure and the magnetic tunnel junction; the ferroelectric/ferromagnetic heterostructure includes a multiferroic material layer and a ferromagnetic layer arranged in a stacked manner, and the magnetic tunnel junction includes a free layer, an insulating layer and a reference layer arranged in a stacked manner, and the heavy metal layer is disposed between the ferromagnetic layer and the free layer. According to one or more embodiments of the disclosure, the spintronic device, the SOT-MRAM storage cell, the storage array and the in-memory computing circuit can realize deterministic magnetization inversion under the condition of no applied field assistance.

Abstract: A point cloud decoding method, a point cloud encoding method, and a decoder are provided in implementation of the disclosure. The decoding method includes the following. A bitstream of a point cloud is parsed to obtain an initial reconstructed value of attribute information of a target point in the point cloud. The initial reconstructed value is converted into an initial luma value and an initial chroma value. A final chroma value is obtained by filtering the initial chroma value with a Kalman filtering algorithm. A final reconstructed value of the attribute information of the target point is obtained based on the final chroma value and the initial luma value. A decoded point cloud is obtained according to the final reconstructed value of the attribute information of the target point.

Abstract: Provided are a point cloud encoding method and decoding method, and an encoder and a decoder. The encoding method comprises: processing attribute information of a target point in a point cloud, so as to obtain a predicted residual of the attribute information of the target point; quantizing the predicted residual on the basis of a quantized weight of the target point and a quantized stride of the target point, so as to obtain a quantized residual of the attribute information of the target point, wherein the quantized weight of the target point is the weight used when weighting the quantized stride of the target point; and encoding the quantized residual, so as to obtain a code stream.

Abstract: A display substrate, a manufacturing method thereof, and a display device are provided. A first test signal line in a test circuit in the display substrate extends in a second direction, and a second test signal line includes a first part extending a the first direction and a second part extending in the second direction; a width of the second part of the second test signal line in a direction perpendicular to the second direction is different from a width of the first test signal line in the direction perpendicular to the second direction; a difference between a resistance of the first test signal line and a resistance of the second test signal line the difference is less than a first threshold. The display substrate as provided is used for display.

Abstract: Provided is an organic electroluminescent device. The organic electroluminescent device is a bottom-emitting single-layer device. The device has maximum external quantum efficiency EQEmax of more than 26%, and has a high roll-off coefficient of greater than or equal to 0.91 at high brightness of 5000 cd/m2 or 11500 cd/m2.

Abstract: Disclosed in embodiments of the present application are a point cloud encoding method, a point cloud decoding method, an encoder, a decoder, and a computer storage medium. The point cloud encoding method comprises: an encoder determining n target neighbouring points of a current point; determining a target prediction mode from k prediction modes on the basis of geometric information of the n target neighbouring points; determining a prediction value of attribute information of the current point according to the target prediction mode and attribute information of the n target neighbouring points; and encoding the current point according to the prediction value.

Abstract: A polypyrrole-coated graphene corrosion inhibitor container and its preparation method and a composite coating and its application are provided. The polypyrrole encapsulated graphene corrosion inhibitor container includes graphene oxide and a polyvinylo layer encapsulated on the surface of the graphene oxide. The invention is based on a polymerization reaction by mixing a polypyrrole acid solution, a graphene oxide dispersion, and an initiator to obtain a polypyrrole encapsulated graphene corrosion inhibitor container. The polypyrrole encapsulated graphene corrosion inhibitor container regulates the release rate of the corrosion inhibitor by wrapping the polypyrrole around the graphene oxide so that it is released rapidly in alkaline solutions and at a slower rate in neutral media.

Abstract: Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) and inhibit PD1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD1-mediated functions.

Abstract: An endogenic protection method for function security and network security of a sensing and decision-making module of an intelligent connected vehicle, including the following steps: designing and implementing four sensing and decision-making units having the same function and a certain degree of heterogeneity, and deploying same on a vehicle; the four units respectively deducing real-time vehicle control decision-making results according to sensed information; an arbiter performing accurate arbitration and approximate arbitration according to decision-making results of three of the sensing and decision-making units; and finally, according to different decision-making results of the arbiter, the vehicle executing a CAN command, or replacing an anomalous unit and performing arbitration again, or operating according to a failure mode until the vehicle stops.