Patents by Inventor Qi Mi
Qi Mi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11854701Abstract: Provided herein are methods for segregating trauma, e.g., blunt trauma, patients into different cohorts based on risk of multiple organ dysfunction syndrome using patient data obtained within a short time window following injury. The methods are useful in providing treatment to trauma patients, and for separating trauma patients into cohorts.Type: GrantFiled: September 13, 2021Date of Patent: December 26, 2023Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Gregory M. Constantine, Timothy Billiar, Qi Mi, Rami Namas, Lukas Schimunek, Yoram Vodovotz
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Publication number: 20220215963Abstract: Provided herein are methods for segregating trauma, e.g., blunt trauma, patients into different cohorts based on risk of multiple organ dysfunction syndrome using patient data obtained within a short time window following injury. The methods are useful in providing treatment to trauma patients, and for separating trauma patients into cohorts.Type: ApplicationFiled: September 13, 2021Publication date: July 7, 2022Inventors: Gregory M. Constantine, Timothy Billiar, Qi Mi, Rami Namas, Lukas Schimunek, Yoram Vodovotz
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Publication number: 20220203586Abstract: A method for producing a metal-plastic composite component comprises: forming a metal substrate with a receiving hole; injecting first plastics into the metal substrate to form a metal-plastic blank, wherein the first plastics are filled in the receiving hole; processing the receiving hole and the first plastics for removing a part of the first plastics by at least one cutter to form a receiving space; and injecting second plastics into the metal-plastic blank to form the metal-plastic composite component, wherein the receiving space is filled with the second plastics. With this method, a combination strength of the metal-plastic composite component is enhanced. A metal-plastic composite component is also provided.Type: ApplicationFiled: December 24, 2021Publication date: June 30, 2022Inventors: GANG LI, QI-MI HUANG, BIN DAI, HUI WANG
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Publication number: 20220067105Abstract: This document describes a search engine that accepts as input different types of data files and conditions for search parameters, including both single and multiple time points, concatenates these data, and outputs data from the different types of files that satisfies the specified search conditions. In one aspect, a method includes receiving a selection of a multiple input data files that each include data on which a search is to be performed. The input data files include different types of data files having different data formats. An in-memory data structure that includes the data of the input data files arranged in a common format is generated. For each of one or more search parameters, data indicating a condition for the search parameter is received. A set of data that satisfies the condition of each of the one or more search parameters is identified in the in-memory data structure.Type: ApplicationFiled: August 26, 2020Publication date: March 3, 2022Inventors: Yoram Vodovotz, Fayten El-Dehaibi, Qi Mi
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Patent number: 11224685Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.Type: GrantFiled: October 10, 2018Date of Patent: January 18, 2022Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Yoram Vodovotz, Alexey Solovyev, David Okonkwo, Maxim Mikheev, Qi Mi, Jorg Gerlach, Gregory M. Constantine
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Publication number: 20210375477Abstract: Provided herein are in silico methods of modeling hepatic inflammation, fibrosis/cirrhosis, and cancer. The models are computer-implemented agent-based models and are useful in determining patient prognoses in hepatic conditions, including viral infections, damage, inflammation, and cancer. The modeling system also is useful in modeling the effects of active agents on normal hepatic tissue or hepatic tissue perturbed by inflammation, infection, damage, fibrosis/cirrhosis, and cancer.Type: ApplicationFiled: April 28, 2021Publication date: December 2, 2021Inventors: Joyeeta Dutta-Moscato, Yoram Vodovotz, Liang-I Kang, Kari Nejak-Bowen, Qi Mi
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Patent number: 11004543Abstract: Provided herein are in silico methods of modeling hepatic inflammation, fibrosis/cirrhosis, and cancer. The models are computer-implemented agent-based models and are useful in determining patient prognoses in hepatic conditions, including viral infections, damage, inflammation, and cancer. The modeling system also is useful in modeling the effects of active agents on normal hepatic tissue or hepatic tissue perturbed by inflammation, infection, damage, fibrosis/cirrhosis, and cancer.Type: GrantFiled: July 29, 2016Date of Patent: May 11, 2021Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Joyeeta Dutta-Moscato, Liang-I Kang, Qi Mi, Kari Nejak-Bowen, Yoram Vodovotz
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Publication number: 20190125955Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.Type: ApplicationFiled: October 10, 2018Publication date: May 2, 2019Inventors: Yoram Vodovotz, Alexey Solovyev, David Okonkwo, Maxim Mikheev, Qi Mi, Jorg Gerlach, Gregory M. Constantine
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Patent number: 10137236Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.Type: GrantFiled: June 11, 2014Date of Patent: November 27, 2018Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Yoram Vodovotz, Alexey Solovyev, David Okonkwo, Maxim Mikheev, Qi Mi, Jorg Gerlach, Gregory M Constantine
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Publication number: 20180322956Abstract: Provided herein are methods for segregating trauma, e.g., blunt trauma, patients into different cohorts based on risk of multiple organ dysfunction syndrome using patient data obtained within a short time window following injury. The methods are useful in providing treatment to trauma patients, and for separating trauma patients into cohorts.Type: ApplicationFiled: May 4, 2018Publication date: November 8, 2018Inventors: Gregory M. Constantine, Timothy Billiar, Qi Mi, Yoram Vodovotz, Rami Namas, Lukas Schimunek
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Publication number: 20170083683Abstract: Provided herein are in silico methods of modeling hepatic inflammation, fibrosis/cirrhosis, and cancer. The models are computer-implemented agent-based models and are useful in determining patient prognoses in hepatic conditions, including viral infections, damage, inflammation, and cancer. The modeling system also is useful in modeling the effects of active agents on normal hepatic tissue or hepatic tissue perturbed by inflammation, infection, damage, fibrosis/cirrhosis, and cancer.Type: ApplicationFiled: July 29, 2016Publication date: March 23, 2017Inventors: Joyeeta Dutta-Moscato, Liang-I Kang, Qi Mi, Kari Nejak-Bowen, Yoram Vodovotz
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Publication number: 20140350527Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.Type: ApplicationFiled: June 11, 2014Publication date: November 27, 2014Inventors: Yoram Vodovotz, Alexey Solovyev, David Okonkwo, Maxim Mikheev, Qi Mi, Jorg Gerlach, Gregory M Constantine
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Patent number: 8630810Abstract: Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.Type: GrantFiled: March 19, 2012Date of Patent: January 14, 2014Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Gilles Clermont, Patricia A. Hebda, Yee Key Li, Qi Mi, David L. Steed, Joshua Thomas Sullivan, Katherine Verdolini Abbott, Yoram Vodovotz, Ivan Petrov Yotov, Gary An
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Publication number: 20130197893Abstract: Provided herein are in silico methods of modeling hepatic inflammation, fibrosis/cirrhosis, and cancer. The models are computer-implemented agent-based models and are useful in determining patient prognoses in hepatic conditions, including viral infections, damage, inflammation, and cancer. The modeling system also is useful in modeling the effects of active agents on normal hepatic tissue or hepatic tissue perturbed by inflammation, infection, damage, fibrosis/cirrhosis, and cancer.Type: ApplicationFiled: June 7, 2011Publication date: August 1, 2013Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Joyeeta Dutta-Moscato, Liang-I Kang, Qi Mi, Kari Nejak-Bowen, Yoram Vodovotz
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Publication number: 20120271611Abstract: Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.Type: ApplicationFiled: March 19, 2012Publication date: October 25, 2012Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Gilles Clermont, Patricia A. Hebda, Yee Key Li, Qi Mi, David L. Steed, Joshua Thomas Sullivan, Katherine Verdolini Abbott, Yoram Vodovotz, Ivan Petrov Yotov, Gary An
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Patent number: 8165819Abstract: Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.Type: GrantFiled: October 10, 2007Date of Patent: April 24, 2012Assignee: The University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Gilles Clermont, Patricia A. Hebda, Yee Key Li, Qi Mi, David L. Steed, Joshua Thomas Sullivan, Katherine Verdolini Abbott, Yoram Vodovotz, Ivan Petrov Yotov, Gary An
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Publication number: 20110190680Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.Type: ApplicationFiled: September 29, 2009Publication date: August 4, 2011Inventors: Yoram Vodovotz, Gregory Constantine, Jorg Christian Gerlach, Qi Mi, Maxim Mikheev, David Okonkwo, Alexey Solovyev
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Patent number: 7984935Abstract: An exemplary latching mechanism for connecting a first component (20) and a second component (40). The latching mechanism includes at least one first engaging portion (408) formed/defined on the second component, at least one latch holder (60a, 60b) fixed relative to the first component, and at least one first latching member (80a, 80b). A first latch-clasping piece (604) extends from the at least one latch holder. The at least one first latching member has at least one second engaging portion (806). The second engaging portion engages with the first engaging portion of the second component. The first engaging portion of the second component and the first latching member are disposed between the first latch-clasping piece of the latch holder and the first component. The present invention further provides an electronic device employing the latching mechanism.Type: GrantFiled: December 14, 2007Date of Patent: July 26, 2011Assignees: Hong Fu Jin Precision Industry (ShenZhen) Co., Ltd., Hon Hai Precision Industry Co., Ltd.Inventors: Yong-Ping Luo, Jia-Gui Xu, Qi-Mi Huang
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Publication number: 20080239647Abstract: An exemplary latching mechanism for connecting a first component (20) and a second component (40). The latching mechanism includes at least one first engaging portion (408) formed/defined on the second component, at least one latch holder (60a, 60b) fixed relative to the first component, and at least one first latching member (80a, 80b). A first latch-clasping piece (604) extends from the at least one latch holder. The at least one first latching member has at least one second engaging portion (806). The second engaging portion engages with the first engaging portion of the second component. The first engaging portion of the second component and the first latching member are disposed between the first latch-clasping piece of the latch holder and the first component. The present invention further provides an electronic device employing the latching mechanism.Type: ApplicationFiled: December 14, 2007Publication date: October 2, 2008Applicants: HONG FU JIN PRECISION INDUSTRY (ShenZhen) CO., LTD., HON HAI PRECISION INDUSTRY CO., LTD.Inventors: YONG-PING LUO, JIA-GUI XU, QI-MI HUANG
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Publication number: 20080228456Abstract: Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.Type: ApplicationFiled: October 10, 2007Publication date: September 18, 2008Inventors: Gilles Clermont, Patricia A. Hebda, Yee Key Li, Qi Mi, David L. Steed, Joshua Thomas Sullivan, Katherine Verdolini Abbott, Yoram Vodovotz, Ivan Petrov Yotov, Gary An