Abstract: This application discloses compounds according to generic Formula I wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

Abstract: The present disclosure discloses a method for group-transmitting multimedia messages. The method comprises the following steps: setting addresses of reception parties at a transmission terminal; after a multimedia message is edited by a user, the transmission terminal establishing a connection via Wireless Fidelity (WIFI) with reception terminals according to the addresses of the reception parties, and transmitting the multimedia message to the reception terminals via the established connection according to the addresses of the reception parties. The present disclosure further discloses a device for group-transmitting multimedia messages. The method and the device of the present disclosure realize the group-transmission of multimedia messages without limiting the size of the multimedia messages, thus profiting the development and popularization of the multimedia message service.

Abstract: The present disclosure discloses a method for group-transmitting multimedia messages. The method comprises the following steps: setting addresses of reception parties at a transmission terminal; after a multimedia message is edited by a user, the transmission terminal establishing a connection via Wireless Fidelity (WIFI) with reception terminals according to the addresses of the reception parties, and transmitting the multimedia message to the reception terminals via the established connection according to the addresses of the reception parties. The present disclosure further discloses a device for group-transmitting multimedia messages. The method and the device of the present disclosure realize the group-transmission of multimedia messages without limiting the size of the multimedia messages, thus profiting the development and popularization of the multimedia message service.

Abstract: The present invention discloses a method and an apparatus of downloading files based on wireless fidelity WIFI. The method comprises: setting a download task, searching an access point for accessing the network; and judging whether the found access point is a WIFI access point; if it is a WIFI access point, then downloading a file indicated by the download task. With the present invention, when a user departs the coverage area of current WIFI access point or the current WIFI access point fails, the system can automatically store the unfinished download task and continuously search a WIFI access point and continue to download the file indicated by the stored download task according to a preset condition after accessing a WIFI access point, thus overcoming the problem that there is limit in using WIFI to download files in the related art, simplifying user operation, and improving user experience.

Abstract: Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer.

Abstract: This invention discloses a method for etching a see-through thin film solar module, comprising: printing ink paste which resists the etching of etching solutions in the protected area of the thin film solar module which is placed under a screen; drying and solidifying the ink paste; coating etching solutions on the thin film solar module; and removing the ink paste. The method of this invention can accurately position the see-through area, achieve various selections of see-through patterns, facilitate the realization of the see-through function in large-area thin film solar modules, and alleviate the problem that a short circuit easily occurs in a see-through thin film solar module.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.

Abstract: This invention discloses a method for etching a see-through thin film solar module, comprising: printing ink paste which resists the etching of etching solutions in the protected area of the thin film solar module which is placed under a screen; drying and solidifying the ink paste; coating etching solutions on the thin film solar module; and removing the ink paste. The method of this invention can accurately position the see-through area, achieve various selections of see-through patterns, facilitate the realization of the see-through function in large-area thin film solar modules, and alleviate the problem that a short circuit easily occurs in a see-through thin film solar module.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification.

Abstract: and the pharmaceutically acceptable salts and esters thereof, X, R1, R2, Y1 and Y2 are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification.

Abstract: and the pharmaceutically acceptable salts and esters thereof X, R1, R2, Y1 and Y2 are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.

Abstract: The present invention relates to compounds according to the structure: Where R is H or CH3; R2 is phosphate which can be free acid or salt; R3 is H, F, Cl, Br, I, OCH3, OCF3 , CF3 or a C1-C3 alkyl group; R4 is H, F, Cl, Br, I, OCH3, OCF3 or CF3; and R5 and R6 are each independently H, F, Cl, Br, I, OCH3, OCF3 or CF3, with the proviso that when any two of R3, R4, R5 or R6 are other than H, the other two of R3, R4, R5 or R6 are H which may be used to treat neoplasia, including cancer.

Abstract: The present invention relates to compounds according to the structure: 1

Abstract: Described herein are compounds with affinity for the 5-HT6 receptor, which have the general formula: wherein R1, R2, R3 and R4 are independently selected from the group consisting of H, halo, OH, C1-6alkyl, C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl and others; R5 is selected from the group consisting of SO2Ar, C(O)Ar, Ar and CH2Ar; R6 and R7 are independently selected from the group consisting of H, C1-6alkyl, optionally substituted phenyl and optionally substituted benzyl; ————— represents a single or double bond; n is selected from an integer of from 1-3; X is selected from the group consisting of CR17 and N; Z is selected from the group consisting of C, CH and N, provided that when ————— is a double bond, Z is C and when ————— is a single bond, Z is selected from CH and N; Ar is an optionally substituted aromatic group selected from the group consisting of phenyl, pyridyl, thienyl,