Abstract: A preparation method of a tumor microparticle encapsulating a metabolic inhibitor includes following steps. A tumor cell is cultivated, and a statin drug is added to a culture medium after the tumor cell grows stably. Then, the tumor cell is irradiated with an ultraviolet, and then the tumor cell is incubated in a cell incubator for 22˜26 hours. After the incubation, cell supernatant is collected and the tumor microparticle encapsulating the metabolic inhibitor is obtained through a gradient centrifugation. The preparation method uses tumor cell-derived microparticles as drug delivery platforms, with a simple preparation process that preserves functions such as biosafety, biocompatibility, targeting, and intercellular communication. The preparation method discovers new uses of a statin drug, which can inhibit tumor growths with the statin drug, regulate tumors metabolism and improve a tumor microenvironment, and have a potential to enhance a chemotherapy efficacy and delay a chemotherapy resistance.

Abstract: Disclosed are fluid controllers configured for removable attachment to a fluid introduction device, wherein the fluid controller comprises a body configured to extend at least partially over the fluid introduction device; an orifice arranged relative to the body to facilitate transfer of a fluid from the fluid introduction device through the fluid controller; a fluid retention structure extending outwardly from at least a portion of the body, wherein the fluid retention structure is configured to engage with a wall of a vaginal canal and inhibit a flow of the fluid from the vaginal canal; and at least one connector configured to releasably attach the fluid controller to the fluid introduction device.

Abstract: Disclosed is a tumor vaccine based on tumor-derived microparticles (TMPs), and a preparation method and use thereof. The preparation method includes the following steps: 1, subjecting tumor cells to separation to obtain TMPs; 2, mixing the TMPs with 0.03 ?g/?l of a polyethyleneimine solution to allow a reaction for 10 min to 20 min, and washing to obtain PEI-modified TMPs (TMPs-PEI); and 3, mixing the TMP-PEI with 0.1 ?g/?l of a lipopolysaccharide solution to allow cross-linking for 15 min to 1 h to obtain the tumor vaccine based on TMPs (TMP-PEI-LPS). A nanomaterial prepared by conducting surface modification on the TMPs with an immunologic adjuvant can be disguised as a bacterial analog to promote the recognition of tumor antigens in vivo. Moreover, the TMPs can retain their immunostimulatory ability and reduce their toxicity by using a cross-linking agent coupled with the immunologic adjuvant.

Abstract: A method, an apparatus, and a system for checking a schematic circuit diagram are provided. The method includes: determining a netlist file and a bill of material (BOM) list of the schematic circuit diagram, where the schematic circuit diagram is drawn by an electronic design automation (EDA) tool; and determining whether parts in the schematic circuit diagram are in a preset part list and determining whether connection relationships among the parts meet preset connection relationships, according to the netlist file and the BOM list, to obtain a check result, where the preset part list includes standard part information of multiple parts.

Abstract: A preparation method of a tumor microparticle encapsulating a metabolic inhibitor includes following steps. A tumor cell is cultivated, and a statin drug is added to a culture medium after the tumor cell grows stably. Then, the tumor cell is irradiated with an ultraviolet, and then the tumor cell is incubated in a cell incubator for 22˜26 hours. After the incubation, cell supernatant is collected and the tumor microparticle encapsulating the metabolic inhibitor is obtained through a gradient centrifugation. The preparation method uses tumor cell-derived microparticles as drug delivery platforms, with a simple preparation process that preserves functions such as biosafety, biocompatibility, targeting, and intercellular communication. The preparation method discovers new uses of a statin drug, which can inhibit tumor growths with the statin drug, regulate tumors metabolism and improve a tumor microenvironment, and have a potential to enhance a chemotherapy efficacy and delay a chemotherapy resistance.

Abstract: Disclosed are fluid controllers configured for removable attachment to a fluid introduction device, wherein the fluid controller comprises a body configured to extend at least partially over the fluid introduction device; an orifice arranged relative to the body to facilitate transfer of a fluid from the fluid introduction device through the fluid controller; a fluid retention structure extending outwardly from at least a portion of the body, wherein the fluid retention structure is configured to engage with a wall of a vaginal canal and inhibit a flow of the fluid from the vaginal canal; and at least one connector configured to releasably attach the fluid controller to the fluid introduction device.

Abstract: Disclosed are fluid controllers configured for removable attachment to a fluid introduction device, wherein the fluid controller comprises a body configured to extend at least partially over the fluid introduction device; an orifice arranged relative to the body to facilitate transfer of a fluid from the fluid introduction device through the fluid controller; a fluid retention structure extending outwardly from at least a portion of the body, wherein the fluid retention structure is configured to engage with a wall of a vaginal canal and inhibit a flow of the fluid from the vaginal canal; and at least one connector configured to releasably attach the fluid controller to the fluid introduction device.

Abstract: Embodiments of the present disclosure provide a method and a device for cross-domain strong logically isolation and secure access control in the Internet of Things (IoT). The method includes the following. When one IoT gateway receives the identity authentication request, the IoT gateway sends the identity authentication request to all IoT gateways in the domain excluding that IoT gateway. When all IoT gateways in the domain receive the identity authentication request, all IoT gateways verify separately whether the identity authentication request is legal. After a certain IoT gateway obtains the identity authentication result, a distributed consensus procedure is initiated. The IoT gateways in the domain reach a consensus on the identity authentication result through a distributed consensus mechanism, and the identity authentication result is written and stored to a block of a blockchain.

Abstract: A method, an apparatus, and a system for checking a schematic circuit diagram are provided. The method includes: determining a netlist file and a bill of material (BOM) list of the schematic circuit diagram, where the schematic circuit diagram is drawn by an electronic design automation (EDA) tool; and determining whether parts in the schematic circuit diagram are in a preset part list and determining whether connection relationships among the parts meet preset connection relationships, according to the netlist file and the BOM list, to obtain a check result, where the preset part list includes standard part information of multiple parts.

Abstract: Embodiments of the present disclosure provide a method and a device for cross-domain strong logically isolation and secure access control in the Internet of Things (IoT). The method includes the following. When one IoT gateway receives the identity authentication request, the IoT gateway sends the identity authentication request to all IoT gateways in the domain excluding that IoT gateway. When all IoT gateways in the domain receive the identity authentication request, all IoT gateways verify separately whether the identity authentication request is legal. After a certain IoT gateway obtains the identity authentication result, a distributed consensus procedure is initiated. The IoT gateways in the domain reach a consensus on the identity authentication result through a distributed consensus mechanism, and the identity authentication result is written and stored to a block of a blockchain.

Abstract: The present disclosure provides an unsupervised exception access detection method and apparatus based on one-hot encoding mechanism. The method includes: encoding each test URL sample by using one-hot encoding mechanism, to obtain a high-dimensional vector; inputting the high-dimensional vector into a pre-built deep autoencoder network for compression and dimension reduction processing, to obtain a two-dimensional vector; performing visualization operation on the two-dimensional vectors by using a two-dimensional coordinate system, to obtain visualized test URL samples; performing a cluster analysis on all visualized test URL samples by using a K-means algorithm, to divide the test URL sample set into a first type and a second type of URL sets; comparing sample sizes of the first type and second type of URL sets, determining the URL set with a larger sample size as a normal URL set, and determining the URL set with a smaller sample size as an abnormal URL set.

Abstract: A method for genetic transformation of edible mushrooms is provided relating to the technical field of genetic transformation of Agaricus bisporus, enoki mushroom and shiitake. The disclosed method for genetic transformation of Agaricus bisporus includes: inoculating Agaricus bisporus liquid mycelia into a foxtail-millet-grain culture medium, and pre-culturing them at 20-25° C. until Agaricus bisporus mycelia grow on surfaces of foxtail millet grains. This method uses the foxtail millet grains as an attachment matrix, and during the pre-culturing and co-culturing, the culture substrate is shaken up every day. The method for genetic transformation of enoki mushroom or shiitake includes: inoculation of enoki mushroom mycelia or shiitake mycelia, activated culturing of agrobacterium, and agrobacterium infecting a foxtail millet grain-enoki mushroom mycelium matrix or a foxtail millet grain-shiitake mycelium matrix.

Abstract: The present disclosure provides an unsupervised exception access detection method and apparatus based on one-hot encoding mechanism. The method includes: encoding each test URL sample by using one-hot encoding mechanism, to obtain a high-dimensional vector; inputting the high-dimensional vector into a pre-built deep autoencoder network for compression and dimension reduction processing, to obtain a two-dimensional vector; performing visualization operation on the two-dimensional vectors by using a two-dimensional coordinate system, to obtain visualized test URL samples; performing a cluster analysis on all visualized test URL samples by using a K-means algorithm, to divide the test URL sample set into a first type and a second type of URL sets; comparing sample sizes of the first type and second type of URL sets, determining the URL set with a larger sample size as a normal URL set, and determining the URL set with a smaller sample size as an abnormal URL set.

Abstract: A method for genetic transformation of edible mushrooms is provided relating to the technical field of genetic transformation of Agaricus bisporus, enoki mushroom and shiitake. The disclosed method for genetic transformation of Agaricus bisporus includes: inoculating Agaricus bisporus liquid mycelia into a foxtail-millet-grain culture medium, and pre-culturing them at 20-25° C. until Agaricus bisporus mycelia grow on surfaces of foxtail millet grains. This method uses the foxtail millet grains as an attachment matrix, and during the pre-culturing and co-culturing, the culture substrate is shaken up every day. The method for genetic transformation of enoki mushroom or shiitake includes: inoculation of enoki mushroom mycelia or shiitake mycelia, activated culturing of agrobacterium, and agrobacterium infecting a foxtail millet grain-enoki mushroom mycelium matrix or a foxtail millet grain-shiitake mycelium matrix.

Abstract: An electrical machine including a winding made of a conductive material is disclosed. The electrical machine also includes an insulating layer disposed around at least a portion of the winding having a dielectric constant that varies as a function of voltage.

Abstract: Disclosed herein is an article comprising an electrical component; and an electrically insulating layer disposed upon the electrical component, wherein the electrically insulating layer comprises a thermosetting polymer and a nanosized filler; wherein the nanosized filler comprises metal oxide and diamond nanoparticles that have an average largest dimension of less than or equal to about 200 nanometers.

Abstract: A film capacitor including a first electrode is provided. The film capacitor also includes a first dielectric layer having a first dielectric constant disposed upon a first electrode, a second dielectric layer having a second dielectric constant disposed upon the first dielectric layer, wherein the second dielectric constant is at least fifty percent greater than the first dielectric constant, and a metalized film disposed upon the second dielectric layer. It further includes a second electrode disposed upon the metalized film.

Abstract: Disclosed herein is a composition comprising a polymeric material; and non-linear dielectric ceramic fillers; wherein the non-linear dielectric ceramic fillers have a dielectric constant that is greater than or equal to about 100 and wherein the dielectric constant of the composition is tunable. Disclosed herein too is a composition comprising a polymeric material; and perovskites; wherein the dielectric constant of a composition is tunable and further wherein the composition has a dielectric constant of about 2 to about 100. Disclosed herein too is a method comprising blending a polymeric resin with non-linear dielectric ceramic fillers to form a composition; wherein the non-linear dielectric ceramic fillers have a dielectric constant of greater than or equal to about 100 and wherein the dielectric constant of the composition is tunable.

Abstract: Disclosed herein is an article comprising an electrical component; and an electrically insulating layer disposed upon the electrical component, wherein the electrically insulating layer comprises a thermosetting polymer and a nanosized filler; wherein the nanosized filler comprises metal oxide and diamond nanoparticles that have an average largest dimension of less than or equal to about 200 nanometers.