Abstract: The present disclosure provides for multi-specific antibodies and antigen-binding fragments thereof that bind to human MUC1 and CD16A, pharmaceutical compositions comprising said antibodies, and use of the antibodies or the compositions for treating a disease, such as cancer.

Abstract: Provided are an imaging method and system for residual stress of a basin insulator and a method for preparing a test block. The imaging method includes cutting and preparing a standard industrial sample of a basin insulator and testing the acoustoelastic coefficient of the standard industrial sample; then obtaining the residual stress data of the basin insulator and obtaining the spatial point sound velocity distribution of the basin insulator; finally, obtaining a stress distribution cloud map of the basin insulator by calculation of the attribute value and the coordinate data of a to-be-measured location, and performing reliability verification based on the residual stress data.

Abstract: A battery and a power consuming device are provided. The battery includes a battery module and a case, where the battery module includes multiple battery cells electrically connected, a shell of each of the multiple battery cells is made of an insulating material, and the case is provided with a cavity configured to accommodate the battery module and the case is made of an insulating material.

Abstract: A battery includes: a battery module including first and second battery cells connected in series in a length direction of the battery, where a first electrode output portion of the first battery cell is electrically connected to a second electrode output portion of the second battery cell in a welded manner; a support arranged between the first and second battery cells and provided with a first accommodating space configured to accommodate the first electrode output portion and the second electrode output portion which are electrically connected to each other; and a structural adhesive configured to fixedly connect the first electrode output portion and the second electrode output portion to the support, where the support is provided with an adhesive filling channel configured to guide the structural adhesive into spaces between the first electrode output portion and the second electrode output portion and the support.

Abstract: A polypyrrole-graphene/polyurethane antifouling coating as well as a preparation method and an application thereof are provided. The polypyrrole-graphene/polyurethane antifouling coating includes component A and component B, wherein the component A mainly includes the following raw materials in parts by weight: 500 parts of group-hydrolyzable polyurethane prepolymer, 25-50 parts of bentonite, 25-50 parts of titanium dioxide, 60-120 parts of zinc oxide, 15-30 parts of talcum powder, and 15-30 parts of polypyrrole-graphene nanofiller; and the component B mainly includes the following raw materials in parts by weight: 5-7 parts of leveling agent, 5-7 parts of defoamer, 6-15 parts of chain extender, 10-25 parts of silane coupling agent, and 1-2 parts of catalyst. The two-component polyurethane coating of the present invention has relatively good adhesion, collision resistance and cracking resistance, and the antifouling property and the antifouling durability can be improved.

Abstract: Embodiments of the present disclosure include systems, methods, and non-transitory computer-readable storage media for automated determination of a patient tumor-immune phenotype from immunofluorescence (IF) image analysis of pathology slides based on a tumor infiltrating lymphocytes score, a non-tumor infiltrating lymphocytes score, and a non-tumor infiltrating lymphocytes at tumor margin score.

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

Abstract: A structure of the compound containing a diphenylmethane structure of the present invention is represented by General Formula (1). The compound containing a diphenylmethane structure of the present invention contains a hydroxyl group, an amino group, a substituted amino group, and an active group, and can be used as an amino acid or peptide C-terminal protection reagent. A peptide synthesis reaction using this protection carrier has a fast reaction speed and a high reagent utilization rate in a suitable solvent system; post-treatment is carried out by means of simple liquid-liquid extraction separation, i.e. effective purification can be carried out, and finally, a product with a high purity can be obtained; and during a synthesis process, the change in solubility is small and an operation process has a strong universality, and therefore, the present method can be developed into a universal production method.

Abstract: A speech brain-computer interface neural decoding system based on Chinese language, a method for controlling the speech brain-computer interface neural decoding system, and a method for implementing the speech brain-computer interface neural decoding system are disclosed. The speech brain-computer interface neural decoding system includes an electroencephalography (EEG) data acquisition module, a significance feature screening and verification module, a speech imagery EEG data decoding module, and an understandable speech synthesis module. The speech brain-computer interface neural decoding system integrates EEG data collection, EEG feature extraction, EEG feature screening, EEG signal decoding for reconstructing speech spectrum information and understandable speech synthesis. After obtaining reconstructed spectrogram features, a Pearson correlation analysis may be performed with original spectrogram features, with a correlation generally being ?80%.

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to a tumor. The oligonucleotide is conjugated to a dendron comprising an end group, a phosphate group, and/or a hydrophobic chain.

Abstract: Embodiments of the present disclosure include systems, methods, and non-transitory computer-readable storage media for automated determination of a patient tumor-immune phenotype from immunofluorescence (IF) image analysis of pathology slides based on a tumor infiltrating lymphocytes score, a non-tumor infiltrating lymphocytes score, and a non-tumor infiltrating lymphocytes at tumor margin score.

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to the lung. The oligonucleotide is conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and/or a hydrophobic chain.

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to the skin. The oligonucleotide is conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and/or a hydrophobic chain.

Abstract: A glycoside hydrolase, relating to the technical field of enzyme engineering/gene engineering. Provided are an enzyme of a GH112 glycoside hydrolase family, and an application of synthesizing human milk oligosaccharides (HMOs) by using an enzyme of a GH112 glycoside hydrolase family. A synthesis reaction is catalyzed by using the enzyme of the glycoside hydrolase family 112 (GH112) that is classified according to a Carbohydrate-Active-Enzymes (CAZy) database (http://www.cazy.org); and lacto-N-tetraose (LNT) is generated in an aqueous solution comprising lactose and/or galactose and/or galactose-1-phosphate and lacto-N-triose (LNTII). The enzyme of the glycoside hydrolase family 112 (GH112), and the preparation method therefor and the application thereof provided by the present invention have economic and social values.

Abstract: A video processing method, apparatus, and device and a storage medium are provided. The method includes: monitoring an operation indication inputted by a user through a personal homepage on a social platform, the personal homepage being used for displaying personal information of the user; obtaining, when the operation indication is a shooting indication for shooting a personal status video, the personal status video; uploading the personal status video to a back-end server of the social platform; and displaying indication information of the personal status video in a personal-information display region of the personal homepage.

Abstract: This disclosure provides compositions, systems, and methods for the topical delivery of therapeutic oligonucleotides with microneedle particles.

Abstract: The present application provides a polypeptide having glycoside hydrolase activity, a related nucleic acid product and enzyme product thereof, a preparation method therefor, and use thereof in synthesis of human milk oligosaccharides (HMOS), particularly lacto-N-biose (LNB). The polypeptide having glycoside hydrolase activity of the present application is used as a catalyst, and can efficiently catalyze the reaction of acetylglucosamine or a carbohydrate having an acetylglucosamine group with a glycosyl donor to generate the lacto-N-biose (LNB). Moreover, a process for producing the LNB based on the peptide is simple and convenient to operate and has a significant increase in production efficiency, thus being more suitable for industrial production.

Abstract: A method for identifying a liver in a CT image of a patient is provided. The method includes applying a liver model to the CT image. The method further includes extracting an internal liver region and an external liver region from the CT image based on the applied liver model. The method also includes performing a graph cut algorithm on the CT image based on the internal liver region and the external liver region to produce a liver image. The performing of the graph cut algorithm on the CT image to produce the liver image may be further based on an internal heart and/or kidney region and an external heart and/or kidney region. A non-transitory computer-readable storage medium encoded with a program is provided.

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

Abstract: This disclosure relates to novel IFN-? signaling pathway target gene targeting sequences. Novel IFNGR1, JAK1, JAK2, and STAT1 targeting oligonucleotides for the treatment of vitiligo are also provided.