Abstract: The present disclosure provides a shift register, a drive method thereof, and a gate drive circuit. The shift register includes an input circuit, a reset circuit, a first output circuit, and a second output circuit. The input circuit is configured to provide an input signal from an input terminal to a first node. The reset circuit is configured to provide a first voltage from a first voltage terminal to the first node under the control of a reset signal from a reset signal terminal. The first output circuit is configured to output from a first output terminal one of a first clock signal and a second clock signal as a first scan signal. The second output circuit is configured to output from a second output terminal the other of the first clock signal and the second clock signal as a second scan signal.

Abstract: Embodiments of the present disclosure include systems, methods, and non-transitory computer-readable storage media for automated determination of a patient tumor-immune phenotype from immunofluorescence (IF) image analysis of pathology slides based on a tumor infiltrating lymphocytes score, a non-tumor infiltrating lymphocytes score, and a non-tumor infiltrating lymphocytes at tumor margin score.

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to the lung. The oligonucleotide is conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and/or a hydrophobic chain.

Abstract: The present application provides an apparatus and a method for preparing an electrode assembly. The apparatus includes: a heating apparatus configured to heat a separator to be wound; and a winding apparatus configured to wind an anode plate, a cathode plate and the heated separator to form an electrode assembly. The apparatus can realize effective heating of the separator, improving the quality of the electrode assembly.

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to the skin. The oligonucleotide is conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and/or a hydrophobic chain.

Abstract: A glycoside hydrolase, relating to the technical field of enzyme engineering/gene engineering. Provided are an enzyme of a GH112 glycoside hydrolase family, and an application of synthesizing human milk oligosaccharides (HMOs) by using an enzyme of a GH112 glycoside hydrolase family. A synthesis reaction is catalyzed by using the enzyme of the glycoside hydrolase family 112 (GH112) that is classified according to a Carbohydrate-Active-Enzymes (CAZy) database (http://www.cazy.org); and lacto-N-tetraose (LNT) is generated in an aqueous solution comprising lactose and/or galactose and/or galactose-1-phosphate and lacto-N-triose (LNTII). The enzyme of the glycoside hydrolase family 112 (GH112), and the preparation method therefor and the application thereof provided by the present invention have economic and social values.

Abstract: A side beam for a battery tray is provided. The battery tray has an accommodating groove for accommodating a battery core. The side beam includes a first body and a second body. The first body includes a main portion and a supporting portion, and the supporting portion is connected to the main portion and is configured to support the battery core. The second body is fixed to the first body. The second body and the first body are separated workpieces. At least a part of the second body is located on a side of the supporting portion away from the accommodating groove.

Abstract: A tray assembly includes a bottom plate that includes a main body portion and a raised edge portion, an expansion beam, and a first sealing member. The main body portion defines an accommodating cavity configured to accommodate a battery, and the raised edge portion is located on a peripheral of the main body portion and around the main body portion. The expansion beam is disposed on a first side of the raised edge portion and is configured to abut with the battery. The first sealing member includes a first portion disposed between the expansion beam and the raised edge portion.

Abstract: A video processing method, apparatus, and device and a storage medium are provided. The method includes: monitoring an operation indication inputted by a user through a personal homepage on a social platform, the personal homepage being used for displaying personal information of the user; obtaining, when the operation indication is a shooting indication for shooting a personal status video, the personal status video; uploading the personal status video to a back-end server of the social platform; and displaying indication information of the personal status video in a personal-information display region of the personal homepage.

Abstract: This disclosure provides compositions, systems, and methods for the topical delivery of therapeutic oligonucleotides with microneedle particles.

Abstract: The present application provides a polypeptide having glycoside hydrolase activity, a related nucleic acid product and enzyme product thereof, a preparation method therefor, and use thereof in synthesis of human milk oligosaccharides (HMOS), particularly lacto-N-biose (LNB). The polypeptide having glycoside hydrolase activity of the present application is used as a catalyst, and can efficiently catalyze the reaction of acetylglucosamine or a carbohydrate having an acetylglucosamine group with a glycosyl donor to generate the lacto-N-biose (LNB). Moreover, a process for producing the LNB based on the peptide is simple and convenient to operate and has a significant increase in production efficiency, thus being more suitable for industrial production.

Abstract: A method for identifying a liver in a CT image of a patient is provided. The method includes applying a liver model to the CT image. The method further includes extracting an internal liver region and an external liver region from the CT image based on the applied liver model. The method also includes performing a graph cut algorithm on the CT image based on the internal liver region and the external liver region to produce a liver image. The performing of the graph cut algorithm on the CT image to produce the liver image may be further based on an internal heart and/or kidney region and an external heart and/or kidney region. A non-transitory computer-readable storage medium encoded with a program is provided.

Abstract: Methods for forming a metal silicate film on a substrate in a reaction chamber by a cyclical deposition process are provided. The methods may include: regulating the temperature of a hydrogen peroxide precursor below a temperature of 70° C. prior to introduction into the reaction chamber, and depositing the metal silicate film on the substrate by performing at least one unit deposition cycle of a cyclical deposition process. Semiconductor device structures including a metal silicate film formed by the methods of the disclosure are also provided.

Abstract: The present disclosure belongs to the field of microbial technology, and in particular relates to a microbial agent for promoting root nodule number increase and root nodule nitrogenase activity increase in leguminous crops and use thereof. The microbial agent is compounded from 4 microbes including Bacillus amyloliquefaciens, Brevibacillus laterosporu, Bacillus mucilaginosus Krassilnikov, and Enterobacter ludwigii by separate fermentative cultivation, concentration and mixing. The microbial agent can effectively promote root nodule number increase and root nodule nitrogenase activity increase, promote crop growth, and improve crop yield and product quality.

Abstract: The present disclosure relates to a microbial agent with functions of preventing and controlling aflatoxin and aflatoxigenic strain thereof and promoting yield increase of crops. The microbial agent is compounded from 5 microbes comprising Bacillus amyloliquefaciens, Brevibacillus laterosporu, Bacillus mucilaginosus Krassilnikov, Enterobacter ludwigii and Myroides odoratimimus by separate fermentative cultivation, concentration and mixing. The microbial agent is applied to a field planting stage of crops such as peanuts, which can effectively reduce the abundance and infection probability of toxin-producing strain such as Aspergillus flavus in soil from the source, reduce the risk of aflatoxin pollution of peanuts after production, improve the quality and safety level of peanuts, and at the same time, promote crop growth, enhance the resistance, and improve the full pod rate and yield, and has significant economic, social and ecological benefits.

Abstract: The disclosure provides methods for the long-term expansion of granulocyte-macrophage progenitors, the granulocyte-macrophage progenitors generated therefrom, and uses of the granulocyte-macrophage progenitors thereof.

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-? signaling with the compounds and compositions of the disclosure.

Abstract: This disclosure relates to novel IFN-? signaling pathway target gene targeting sequences. Novel IFNGR1, JAK1, JAK2, and STAT1 targeting oligonucleotides for the treatment of vitiligo are also provided.

Abstract: Various embodiments of the teachings herein include a method for training a model configured to monitor a working status of equipment based on sensor data. An example method includes: training a model using a training data set including historical sensor data gathered only when the equipment is under normal working conditions; testing the model with sensor data causing a false alarm, sensor data of the equipment's historical confirmed failure, and sensor data within pre-defined recent time period when the equipment is under normal working conditions; and activating the model if the model passes test, otherwise rejecting the model.