Abstract: A method and a system for calculating tumor neoantigen burden (TNB) are provided. The method includes: step S1: processing a normal sample and a tumor sample, sequencing a specific region and detecting somatic mutations in the sample; step S2: annotating and filtering the somatic mutations, and translating to obtain mutant peptide sequences of a patient; step S3: filtering the mutant peptide sequences to obtain neopeptide sequences based on a proteome of the normal sample; step S4, performing a human leukocyte antigen (HLA) typing analysis based on alignment data of the normal sample to obtain HLA genotypes of the sample; step S5, predicting binding affinities between the neopeptide sequences and the HLA genotypes to obtain specific neoantigens of the sample, and performing a weighted scoring on each of the specific neoantigens and calculating the TNB of the sample.

Abstract: A transporting device can transport at least one product, the transporting device includes a mounting frame, a driving mechanism, a transmitting mechanism including a plurality of bent portions, a plurality of guiding mechanisms, and a supporting mechanism. Each guiding mechanism includes a rotating wheel and a guiding plate. Each bent portion is connected to the rotating wheel. The guiding plate is connected to the rotating wheel. The supporting mechanism can support the product. The driving mechanism is further connected to the rotating wheel and can drive the transmitting mechanism to rotate to drive the supporting mechanism to move. The driving mechanism is further connected to the guiding plate, the guiding plate and the rotating wheel can synchronously rotate to drive the supporting mechanism to pass through the bent portions. The present disclosure further provides a heating device.

Abstract: A graft copolymer and a preparation method and use thereof. The method for preparing a graft copolymer includes: dissolving an N-ethyl-2-pyrrolidinone-substituted flavan-3-ol (EPSF) and a starch in a polar organic solvent, to obtain a raw material solution; and mixing the raw material solution with ascorbic acid and hydrogen peroxide to obtain a mixture, and subjecting the mixture to a grafting reaction, to obtain the graft copolymer.

Abstract: A method and a platform for detecting an immunogenicity of a tumor neoantigen are provided. Specifically, the detection method includes the following steps: culturing human peripheral blood monocytes ex vivo for 13 days, adding an antigenic peptide fragment of human influenza virus and stimulating and activating cytokines, antigenic peptides, and immunoadjuvants during the 13 days, and finally conducting enzyme-linked immunospot (ELISPOT) chromogenic reaction and instrument-based scanning, counting, and analysis to detect the immunogenicity of tumor neoantigen. An application of the detection method and platform in biomedicine is provided. Compared with the prior art, the detection method and platform have advantages and characteristics of a short detection period, high convenience, low consumption of experimental cells, and low detection cost. Therefore, the detection method and platform can be used for ex vivo high-throughput assay for the immunogenicity of the tumor neoantigen.

Abstract: Provided are a robot-based random warehousing method and apparatus, an electronic device, and a storage medium. In the method, randomly allocated goods position information is acquired, and a shelving robot is controlled according to the goods position information to carry goods to goods position corresponding to the randomly allocated goods position information; a prompt is given to a picker to prompt the picker to take the goods from the shelving robot and place the goods at the goods position, and goods information and goods position information of the goods are synchronized to an unshelving order; and order information of the unshelving order is acquired and a picking robot in the vicinity of the goods position is controlled to move to the goods position to instruct a picker to pick the goods at the goods position and pass the goods to the picking robot.

Abstract: A discharge flow rate of a loss-in-weight scale is controlled by continuously changing control outputs to save the time necessary for data stabilization. A curve relating the discharge flow rate and the control output is obtained by using the functional relationship between the control output and time and the functional relationship between the material weight and time. The discharge flow rate can be precisely controlled by directly selecting or inputting a value of the control output, to achieve the objectives of direct controlling and of avoiding the time for data stabilization.

Abstract: A robot-based electronic commerce warehouse order picking method is provided, box body identity information of a circulation box is acquired and the circulation box and a robot are bound based on the box body identity information, the circulation box includes at least one circulation position, a tag and a goods placement mark are correspondingly arranged at the circulation position, and the box body identity information includes information of the tag and information of the goods placement mark; warehouse order information is acquired and the warehouse order information is associated with the box body identity information to obtain order binding information; an interaction terminal of the robot is controlled according to the order binding information to display an interaction interface to instruct a picker to pick goods at a corresponding goods position and place the goods at the circulation position according to the goods placement mark.

Abstract: The embodiments of the present disclosure relate to an order picking method and device, and a storage medium. The method includes: acquiring at least one piece of order information; acquiring information of at least one storage bin in a circulation box, wherein a plurality of storage bins are arranged in the circulation box; associating the at least one piece of order information with the information of the at least one storage bin, wherein the at least one piece of order information is in one-to-one correspondence with the information of the at least one storage bin; acquiring position information of all commodities, corresponding to the at least one piece of order information, in a commodity warehouse; determining an order picking path according to commodity information and the position information; and moving the circulation box in the commodity warehouse according to the order picking path for completing commodity picking.

Abstract: A method is provided for measuring an energy efficiency of a quantitative weighing device. A data measurement part is formed by: recording a control time of fast charging, recording a control time of slow charging, recording a comparison prohibition time, and recording weighing data. A current device reliability parameter, a fast charging feed flow, and a slow charging feed flow are calculated, based on the comparison prohibition time and the control time of slow charging. The fastest feed time under a requirement of a target reliability parameter is calculated as the difference between the target reliability parameter and the calculated control reliability parameter. By using the method, application data, such as capability of a quantitative control device and energy efficiency of the quantitative weighing device, can be intuitively obtained. This facilitates commissioning, maintenance, and use of the quantitative weighing control device.

Abstract: Provided are a robot-based random warehousing method and apparatus, an electronic device, and a storage medium. In the method, randomly allocated goods position information is acquired, and a shelving robot is controlled according to the goods position information to carry goods to goods position corresponding to the randomly allocated goods position information; a prompt is given to a picker to prompt the picker to take the goods from the shelving robot and place the goods at the goods position, and goods information and goods position information of the goods are synchronized to an unshelving order; and order information of the unshelving order is acquired and a picking robot in the vicinity of the goods position is controlled to move to the goods position to instruct a picker to pick the goods at the goods position and pass the goods to the picking robot.

Abstract: Provided are a robot-based electronic commerce warehouse order picking method, apparatus and system, an electronic device, and a storage medium. In the method, a circulation box and a robot are bound by means of acquiring box body identity information of the circulation box including at least one circulation position, wherein a tag and a goods placement mark are correspondingly arranged at the circulation position, and the box body identity information includes information of the tag and information of the goods placement mark; warehouse order information is acquired and the warehouse order information is associated with the box body identity information to obtain order binding information; an interaction terminal of the robot is controlled according to the order binding information to display an interaction interface to instruct a picker to pick goods at a corresponding goods position and place the goods at the circulation position according to the goods placement mark.

Abstract: Provided is a robot-based subarea logistics picking method, which includes that: order information of goods is acquired, the goods being arranged in a warehouse area and the order information including goods location information of the goods (S10); picking location information, mapped by the goods location information, of a robot is acquired (S11); and a planned path for guiding the robot is calculated according to the picking location information to guide the robot to go to a corresponding picking location to convey the goods picked by a picker to a packaging area (S12). Therefore, an occupation rate of a warehouse space is reduced, the flexibility in planned use of the warehouse space is improved, and moreover, human-machine configuration can be implemented flexibly to meet requirements of small-batch high-frequency orders changing dramatically with peak values on subarea picking efficiency and flexibility in an electronic commerce environment.

Abstract: A weighing system and a weighing method are disclosed having uninterrupted weighing functions. A plurality of load cells in the weighing system are arranged so that each load cell has a local small neighborhood, the local small neighborhood being defined by four neighboring points in front, back, left, and right of the load cell and four points on diagonal directions in a matrix. A weighing control module polls the load cells to determine whether there is failed load cell(s), and performs a calculation: W.=f(W1,W2,W3,W4,W5,W6,W7), where f is a non-linear mapping; and W1 . . . W8 represents weighing outputs of load cells corresponding to the eight points in the local small neighborhood so as to calculate an estimated weighing output of the failed load cell.

Abstract: A weighing system and a weighing method are disclosed having uninterrupted weighing functions. A plurality of load cells in the weighing system are arranged so that each load cell has a local small neighborhood, the local small neighborhood being defined by four neighboring points in front, back, left, and right of the load cell and four points on diagonal directions in a matrix. A weighing control module polls the load cells to determine whether there is failed load cell(s), and performs a calculation: W.=f (W1, W2, W3, W4, W5, W6, W7), where f is a non-linear mapping; and W1 . . . W8 represents weighing outputs of load cells corresponding to the eight points in the local small neighborhood so as to calculate an estimated weighing output of the failed load cell.

Abstract: The present invention is directed to a method for promoting differentiation, activation and proliferation of human T helper lymphocytes such as those that express IL17 and IL22 (Th-IL17+ and Th-IL22+ T cells) and provides methods for decreasing T cell activation or T cell biological activity, inhibiting an immune response and treating autoimmune diseases by increasing the biological activity of or administering a transcription factor such as a Krüppel-like factor or a forkhead box factor, and pharmaceutical compositions effective for these methods. Also, the present invention provides methods for increasing T cell activation or T cell biological activity, stimulating an immune response and treating diseases such as cancers and infections by decreasing the biological activity of or administering an inhibitor of a transcription factor such as a Krüppel-like factor or a forkhead box factor and pharmaceutical compositions effective for these methods.

Abstract: The present invention is directed to a method for promoting differentiation, activation and proliferation of human T helper lymphocytes such as those that express IL17 and IL22 (Th-IL17+ and Th-IL22+ T cells) and provides methods for decreasing T cell activation or T cell biological activity, inhibiting an immune response and treating autoimmune diseases by increasing the biological activity of or administering a transcription factor such as a Krüppel-like factor or a forkhead box factor, and pharmaceutical compositions effective for these methods. Also, the present invention provides methods for increasing T cell activation or T cell biological activity, stimulating an immune response and treating diseases such as cancers and infections by decreasing the biological activity of or administering an inhibitor of a transcription factor such as a Krüppel-like factor or a forkhead box factor and pharmaceutical compositions effective for these methods.

Abstract: Provided herein are methods of repairing, treating, managing or preventing brain damages. In some embodiments, the methods comprise applying a direct current electric field to direct or modulate the migration of NSPCs towards the region of the brain damage. In certain embodiments, the methods comprise administering an electric field between a cerebral ventricle and the meninx, inclusive, of the brain where the brain damage occurs. In other embodiments, the methods comprise activating a membrane protein of NSPCs by a direct current electric field. In further embodiments, the methods comprise interactions of a membrane protein in NSPC with Rac1, Tiam1, Pak1, and actin cytoskeleton in a protein complex in the presence of an electric field. In still further embodiments, the methods comprise applying an electric field to promote neurogenesis in the subventricular zone or subgranular zone of the brain.