Abstract: Provided herein are Bridged Compounds having the following structures: wherein R1a, R1b, R1c, R1d, R2a, R2b, R2c, R2d, R3a, R3b, R3c, R3d, R4, R5, R6, R7, R8, m1, m2, m3, n2, n3, n4, q, X1, X2, Y1, Y2, L1 and ring A are as defined herein, compositions comprising an effective amount of a Bridged Compound, and methods for treating or preventing various diseases, e.g., pancreatic cancer, or a condition treatable or preventable by inhibition of the function of KRAS protein. In another aspect, a Bridged Compound is useful for treating or preventing a condition treatable or preventable by inhibition of the function of KRAS protein with G12D mutation. In another aspect, a Bridged Compound is useful for treating or preventing a condition treatable or preventable by inhibition of a RAS/MAPK pathway.

Abstract: The present disclosure provides a data processing method, apparatus and device and a storage medium.

Abstract: The present invention relates to a semiconductor memory cell structure, a semiconductor memory as well as preparation method and application thereof. The semiconductor memory cell structure includes: a substrate; and a first transistor layer, an isolation layer and a second transistor layer. The first transistor layer includes a first stack structure formed by stacking a first source, a first channel, and a first drain from bottom to top; and a first gate located on a sidewall of the first stack structure. The second transistor layer includes: a second stack structure formed by stacking a second drain, a second channel, and a second source from bottom to top; and a second gate located on a sidewall of the second stack structure, at least a part of a sidewall of the second drain is in direct contact with the first gate.

Abstract: The present disclosure provides a display substrate and a display device, and belongs to the field of display technology. The display substrate includes: a base substrate having a peripheral region, and thin film transistors disposed in the peripheral region of the base substrate. A gate electrode of the thin film transistor includes a plurality of sub-electrodes arranged at intervals.

Abstract: A lock, a vehicle parking system, and a vehicle parking method are provided. The lock includes a main body, a lock switch, a lock controller, a lock communication circuit, and a battery. The battery is connected to the lock switch, the lock controller, and the lock communication circuit, and configured to supply electrical energy to the lock switch, the lock controller, and the lock communication circuit. The lock communication circuit is connected to the lock controller, and transmits a locking instruction or an unlocking instruction to the lock controller when receiving the locking instruction or the unlocking instruction from a second device located outside the lock. The lock controller is connected to the lock switch connected to the main body, and the lock controller controls, when receiving the locking instruction or the unlocking instruction, the main body to perform a locking operation or an unlocking operation through the lock switch.

Abstract: The present disclosure provides a determination method, an elimination method and an apparatus for an electron microscope aberration. The determination method comprises: training a neural network for image recognition using a plurality of electron microscope simulation images to obtain an electron microscope image recognition model; recognizing an electron microscope image of an experimental sample using the electron microscope image recognition model to obtain the electron microscope simulation image corresponding to the electron microscope image of the experimental sample; and obtaining the corresponding set aberration as an imaging aberration of the electron microscope image of the experimental sample according to the electron microscope simulation image corresponding to the electron microscope image of the experimental sample.

Abstract: A method for quantifying and assessing a scheduling risk considering source load fluctuation and rescheduling, and an apparatus for quantifying and assessing a scheduling risk considering source load fluctuation and rescheduling are provided. The method includes establishing a scene set considering a new energy disturbance; establishing and solving a rescheduling optimization model considering the new energy disturbance in each scene based on a preset scheduling plan according to the scene set, so as to obtain a solving result of the rescheduling optimization model; and calculating a risk quantifying and assessing result corresponding to the preset scheduling plan according to the solving result of the rescheduling optimization model.

Abstract: Provided are a surface zwitterionized silicone antifouling coating and a preparation method thereof. In the disclosure, hydroxyl-terminated polydimethylsiloxane and N-aminoethyl-3-aminopropyl methyl dimethoxysilane are used as raw materials, and tetramethylammonium hydroxide pentahydrate is used as a catalyst, thereby preparing a series of polydimethylsiloxane resins containing amino side chains in different proportions; then side chain amino modified polydimethylsiloxane is crosslinked and cured by using 3-glycidyloxypropyltrimethoxysilane as a curing agent; after that, the cured silicone coating is soaked in a solution of 1,3-propane sultone in acetone for ionization.

Abstract: Provided is an electric cable driving mechanism having a self-return function. The electric cable driving mechanism includes a housing assembly, an electric motor, a three-stage transmission mechanism and a multifunctional nut, the three-stage transmission mechanism includes a coil spring assembly, the electric motor is fixed to the housing assembly, and the three-stage transmission mechanism and the multifunctional nut are mounted in the housing assembly; and the multifunctional nut includes two cable mounting grooves and is in transmission connection to the electric motor by means of the three-stage transmission mechanism. According to the electric cable driving mechanism having a self-return function of the present disclosure, the three-stage transmission mechanism is used, and outputs a larger force compared with two-stage transmission; and a split multifunctional screw rod is easy to mount, such that mounting of a coil spring during assembly is prevented from scratching the screw rod.

Abstract: A storage device is provided, including: a substrate; word lines extending in a first direction; bit lines extending in a second direction perpendicular to the first direction; and a storage unit including a plurality of storage units, each of which is electrically connected to a word line and a bit line. Each storage unit includes: an active region extending in a third direction inclined with the first direction; a vertical stack of a first source/drain layer, a channel layer and a second source/drain layer; and gate stacks between the first source/drain layer and the second source/drain layer, and on opposite sides of the channel layer in a fourth direction orthogonal to the third direction, to sandwich the channel layer. The word line corresponding to each storage unit extends across the storage unit in the first direction to be electrically connected to the gate stacks on opposite sides.

Abstract: The present disclosure provides a signal transmission/reception method, user equipment, and network equipment, the method including: determining, by a user equipment, an available random access occasion and a timing advance (TA) value; performing listen before talk (LBT) before a TA of the first available random access occasion; transmitting, if the LBT is successful, the random access preamble on the random access occasion.

Abstract: A second blockchain system receives a first consensus message from a first blockchain system, the first blockchain system includes first nodes that provide services to at least a first account, and the second blockchain system includes second nodes that provide services to at least a second account. The first consensus message indicates a first plurality of the first nodes reaches a consensus for transferring a resource from the first account to the second account. The second blockchain system transfers the resource in the task to the second account. The transferring includes that a node in the second nodes adds the resource to the second account and generates a fourth block that records a completion of a transfer event. A second consensus message is transmitted from the second blockchain system to the first blockchain system in response to a second plurality of the second nodes completing the transfer event.

Abstract: A dielectric barrier discharging tube, which has a synergistic column of needle electrodes to utilize a plurality of channels to adsorb catalysts, is provided. The dielectric barrier discharging tube includes: a quartz tube, a high-voltage pole, an inner electrode, and a plurality discharging needle sets. Two catalytic blocks are arranged respectively on two sides of each set discharging needles. Each catalytic block defines at least one inclined inner channel and at least one inclined outer channel. A higher end of each channel faces towards the discharging needle, and a lower end of each channel faces towards the discharging needle.

Abstract: The present invention provides a joint optimization method and system for delay and spectrum occupation in a cloud-edge collaborative network. The method includes: initializing a cloud-edge collaborative network, and generating a set of user requests; establishing a target function of minimum average end-to-end delay and minimum spectrum slot occupation of a user request; during processing of each user request based on the target function, sequentially determining whether a node and path selection uniqueness constraint, a mobile edge computing (MEC) server load constraint, a spectrum resource occupation and uniqueness constraint, a spectrum continuity constraint, and a spectrum consistency constraint are satisfied, where if all constraints are satisfied, the user request is successfully processed, and the process turns to step S4; or if any constraint is not satisfied, the user request fails to be processed; and calculating average end-to-end delay and spectrum resource occupancy of the user request.

Abstract: A method and a system for calculating tumor neoantigen burden (TNB) are provided. The method includes: step S1: processing a normal sample and a tumor sample, sequencing a specific region and detecting somatic mutations in the sample; step S2: annotating and filtering the somatic mutations, and translating to obtain mutant peptide sequences of a patient; step S3: filtering the mutant peptide sequences to obtain neopeptide sequences based on a proteome of the normal sample; step S4, performing a human leukocyte antigen (HLA) typing analysis based on alignment data of the normal sample to obtain HLA genotypes of the sample; step S5, predicting binding affinities between the neopeptide sequences and the HLA genotypes to obtain specific neoantigens of the sample, and performing a weighted scoring on each of the specific neoantigens and calculating the TNB of the sample.

Abstract: The disclosure provides a displaying substrate, a manufacturing method thereof, and a display panel, and relates to the technical field of display. The displaying substrate comprises a first supporting base (1), plurality of vibrating element modules (2), and a display module (3). The display module (3) comprises display units (31), connecting units (32) and hollowed-out units (33). Each connecting unit (32) is located between two adjacent display units (31). Each hollowed-out unit (33) is located between two adjacent display units (31) except an area where the corresponding connecting unit (32) is located. The hollowed-out units (33) are provided with cavities (40) corresponding to the vibrating element modules (2). Orthographic projections of the hollowed-out units (33) on a reference plane cover orthographic projections of the vibrating element modules (2) on the reference plane. The vibrating element modules (2) and the cavities (40) form a transducer.

Abstract: An image rendering method and apparatus, a device, and a medium. The method includes: determining a pre-captured initial rendering video stream for a background image; obtaining initial rendering coordinates of each rendering pixel in each initial rendering image frame in the video stream, and obtaining a rendering moment of each initial rendering image frame in the initial rendering video stream; determining the amount of noise of each rendering pixel at the corresponding rendering moment according to the corresponding initial rendering coordinates, a preset noise texture, and the corresponding rendering moment, and obtaining target rendering coordinates of each rendering pixel according to the corresponding amount of noise; and updating the initial rendering coordinates of each rendering pixel according to the corresponding target rendering coordinates to obtain a target rendering image, and rendering the background image according to a target rendering video stream composed of all target rendering images.

Abstract: The present application discloses a class of guaianolide sesquiterpene lactone derivatives and pharmaceutical use thereof. The guaianolide sesquiterpene lactone derivative or a pharmaceutically acceptable salt thereof is shown as general formula I. In the present application, a class of novel guaianolide sesquiterpene lactone derivatives are found by structural optimization with abundant natural ingredients such as parthenolide and dehydrocostus lactone as raw materials, which derivatives have good inhibitory activity on the activation of the NLRP3 inflammasome, and the chemical stability, water solubility and oral bioavailability of which are significantly improved, and it is verified by experiments that the derivatives have inhibitory effects on the activity of the NLRP3 inflammasome and have potential pharmaceutical applications.

Abstract: The utility model relates to a grounded shrapnel structure of an H-MTD male connector, including a housing of a hollow structure, a shrapnel in an arch shape, and a guide block. The front end of the housing is provided with an opening. The guide block is arranged horizontally. One end of the guide block is connected to one end of the opening. The other end of the guide block is connected to one end of the shrapnel. The structure uses only two surfaces at top and bottom that are grounded, thereby reducing the number of openings, improving the strength of a sidewall, and enhancing the shielding effect. In addition, the guide block can play the function of anti-scratching during assembly, which can effectively avoid the damage to the shrapnel during assembly and improve yield.