Abstract: The present invention relates to a thiophene compound and an application thereof. The present invention specifically relates to a compound represented by formula (II) and a pharmaceutically acceptable salt thereof, wherein L1 is —C(?O)— or —C(?O)—NH—; R1 is R1a or aa; ring A is bb or cc; R1a is C1-3 alkyl substituted with 1, 2 or 3 Ra; and R3 is independently H, halogen or C1-3 alkoxy. The compound represented by formula (II) and the pharmaceutically acceptable salt thereof can better inhibit the activity of LSD1, further shows significant inhibitory activity against NCI-H1417 cell proliferation, and has good pharmacokinetic properties (including good oral bioavailability, oral exposure, half-life, and clearance rate, etc.).

Abstract: A self-contained game monitoring device captures images of a game table and identifies objects relevant to the game and identifies values associated with objects. During the course of the game, the device can detect a violation of the players' bets according to pre-configured game rules. At the end of each game, the device can determine the outcome of the game (e.g., the win/lose/push on each bet) and can determine whether the dealer's action (e.g., payout on each bet) is consistent with the device's judgment. If an inconsistent action is detected, the device can notify the dealer/supervisor about a potential mistake.

Abstract: A battery and an electrical device are provided. The battery comprises: a battery cell, a first wall of the battery cell being provided with a first pressure relief mechanism; a thermal management component for regulating the temperature of the battery cell, wherein the thermal management component is attached to a second wall of the battery cell, the second wall being different from the first wall and the area of the second wall being greater than or equal to that of the first wall; and a discharge pathway configured to be capable of getting in communication with the interior of the battery cell via the first pressure relief mechanism when the first pressure relief mechanism is actuated, so that emissions of the battery cell are discharged to the discharge pathway. The battery and the electrical device of embodiments of the present application can improve the safety of the battery.

Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Abstract: A cylindrical battery cell, a battery and a method for forming cylindrical battery cell are provided. In the cylindrical cell, on a bottom side of a cell housing, a copper plate is forged with the cell housing to form a bi-metal plate, and the copper plate is welded with a jellyroll structure; on an upper side of the cell housing, a cap component is configured on the jellyroll structure, and an aluminum terminal of the cap component is welded with the jellyroll structure. Therefore, the manufacturing process can be simplified and the costs consequently can be reduced; furthermore, joining/welding the cell housing with the jellyroll structure is achieved by using a laser from outside of the cell housing, while risk of corrosion of cell housing is not introduced.

Abstract: Compositions and methods are provided relating to immunostimulatory TLR agonist nanoparticle formulations. Methods are provided for treating cancer, by stimulating an immune response to cancer cells through administering to an individual mammal an effective dose or series of doses of an immunostimulatory composition comprising an immunostimulatory TLR agonist-nanoparticle; optionally in combination with a second immune regulatory agent.

Abstract: This application provides a display method and an electronic device. When the electronic device switches from a screen-off mode to a lock-screen mode, the electronic device may perform gradual expansion from a last image frame displayed in a screen-off interface, and in a gradual expansion process, successively play a transition animation during switching from the screen-off interface to a lock-screen interface.

Abstract: An electrical connector includes a base portion, a tail portion extending from a first side of the base portion, a serpentine portion having a first end connected to a second side of the base portion opposite to the first side, a movable head portion connected to a second end of the serpentine portion, and a housing in which an accommodation chamber is formed to accommodate the serpentine portion. The housing has a first end connected with the base portion and a second end provided with a limiting portion confining the serpentine portion within the accommodation chamber. The head portion is movable so as to pass through the limiting portion. The electrical connector is made of a single piece of metal.

Abstract: It relates to Bacillus velezensis, a culture method and use thereof; Bacillus velezensis TA-3-BV serving as an endogenous antagonistic strain of sweet cherry for the first time, and a nucleotide sequence of 16S rDNA of the Bacillus velezensis TA-3-BV is shown as SEQ ID NO. 1. The Bacillus velezensis TA-3-BV has board-spectrum antibacterial activity for sweet cherry, has an inhibitory effect on a variety of pathogenic fungi, and especially has an excellent inhibitory effect on Rhizopus stolonifer serving as a soft rot pathogen of sweet cherry, with an inhibition rate of 69.82±1.43%; in addition, the Bacillus velezensis TA-3-BV has a good inhibitory effect on the postharvest rot of sweet cherry fruits, can slow down the rot process of fruits, can delay the rot of fruits by 2-3 d, thereby providing a novel method for postharvest preservation of sweet cherry.

Abstract: Provided is a method for analyzing oil film multi-field coupling characteristics of series friction pairs of an axial piston pump in the disclosure. According to the disclosure, based on an oil film independent analysis model of macro structures, motion states and heterogeneities of service conditions of three major friction pairs of the axial piston pair, surface microstructures of the friction pairs is introduced, and a solid-liquid-thermal multi-field coupling analysis method of the friction pairs is proposed for macro information interaction. Finally, a coupling solution of the oil film bearing characteristics of the multi-friction pairs of the system is realized by the multi-scale and multi-degree-of-freedom hydraulic-dynamic global coupling method.

Abstract: An organic frame material having a cobalt-containing isopoly-molybdic acid metal, a method of manufacturing the same, and applications thereof are provided. The organic frame material having a cobalt-containing isopoly-molybdic acid metal includes a three-dimensional network structure comprising cobalt ions coordinated with 2,3,5,6-tetrafluoro-bis (1,2,4-triazole-1-methyl) benzene ligands and trinuclear molybdate anions. The organic frame material having a cobalt-containing isopoly-molybdic acid metal has higher catalytic activity towards the bulk ring-opening of p-dioxanone. The resulting poly(p-dioxanone) has a weight average molecular weight exceeding 70,000 and is capable of being applied in the field of high polymer materials.

Abstract: A computer implemented method. Includes: obtaining, from a sensor system onboard a vehicle, a plurality of hypotheses for an orientation of an object in a vicinity of the vehicle, relative to a coordinate system of the vehicle; estimating, based on the plurality of hypotheses, values of a probability distribution for the orientation of the object at a plurality of candidate orientations; and estimating, based at least in part on the estimated values of the probability distribution at the plurality of candidate orientations, the orientation of the object relative to the coordinate system.

Abstract: A method of fabricating vertical cavity surface emitting laser, comprising: providing a first substrate formed with a dielectric DBR and a first bonding layer, and a second substrate formed with a etch-stop layer, a heavily doped layer, an active region, a current-confinement layer, and an arsenide DBR firstly, then sticking a third substrate on the arsenide DBR, then removing the second substrate and the etch-stop layer, next bonding the heavily doped layer to the dielectric DBR, next removing the third substrate, finally forming a p-type electrode contact and an n-type electrode contact.

Abstract: The present disclosure provides a method of transmitting and/or receiving a transport block. The method includes: receiving and/or transmitting a transport block according to information for scheduling multiple transport blocks. The present disclosure also provides a method for downlink transmission, a method of receiving an NRS on a non-anchor carrier, and corresponding UE, base station, and computer readable medium.

Abstract: The present invention relates to a low-sugar or sugar-free type pectin soft candy and a preparation method thereof. The soft candy comprises sugar alcohol, glycerin and pectin, wherein the sugar alcohol comprises maltitol, a soluble sugar alcohol selected from erythritol, isomalt, xylitol, lactitol and mannitol, as well as sorbitol, which is characterized in that the weight ratio of the maltitol, the soluble sugar alcohol and the sorbitol is 1:(0.10-0.65):(0.03-0.26), and the weight ratio of the maltitol to the glycerol is 1:(0.04-0.52).

Abstract: Certain aspects of the present disclosure provide techniques for wireless communications. An example method generally includes calculating a first power headroom report (PHR) for a half duplex (HD) operating mode, calculating a second PHR for a full duplex (FD) operating mode during which maximum uplink transmit power is subject to one or more self-interference constraints, determining whether to report the first PHR, the second PHR, or both, and reporting at least one of the first PHR or the second PHR to a network entity, in accordance with the determination.

Abstract: The present disclosure relates to a cam phase adjuster that includes a stator, a rotor, a front cover and at least one locking pin.

Abstract: Methods, systems, an apparatus, including computer programs encoded on a storage device, for training an image classifier. A method includes receiving an image that includes a depiction of an object; generating a set of poorly localized bounding boxes; and generating a set of accurately localized bounding boxes. The method includes training, at a first learning rate and using the poorly localized bounding boxes, an object classifier to classify the object; and training, at a second learning rate that is lower than the first learning rate, and using the accurately localized bounding boxes, the object classifier to classify the object. The method includes receiving a second image that includes a depiction of an object; and providing, to the trained object classifier, the second image. The method includes receiving an indication that the object classifier classified the object in the second image; and performing one or more actions.

Abstract: The present disclosure provides a display panel, a method for manufacturing a display panel and a display device. The display panel includes a substrate, and a light emitting element array and a quantum dot color filter array arranged on the substrate, the quantum dot color filter array is arranged on a light exiting side of the light emitting element array, and quantum dot color filters in the quantum dot color filter array correspond to light emitting elements in the light emitting element array one to one, and the display panel further includes a blocking structure arranged between the light emitting element array and the quantum dot color filter array so as to block heat dissipated by the light emitting elements from being conducted to the quantum dot color filters.

Abstract: The present application discloses a liquid cooled electronic device. The liquid cooled electronic device comprises a chassis unit. The chassis unit is circumferentially closed relative to a first direction. A first accommodating space extending in the first direction is formed within the chassis unit. A liquid cooled computing unit and a liquid cooled power supply unit that are electrically connected are arranged in the first accommodating space. The liquid cooled computing unit and the liquid cooled power supply unit are respectively inserted into the first accommodating space through a first guide rail and a second guide rail. The first guide rail and the second guide rail are arranged in parallel in the first direction. That is, the liquid cooled computing unit and the liquid cooled power supply unit are arranged in parallel via the parallel arrangement of the first guide rail and the second guide rail.