Abstract: The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

Abstract: A method and apparatus for removing foreign material from an upwardly oriented surface of a body-in-white are provided. The apparatus includes a vacuum member mounted to a frame for removing foreign material from the associated upwardly oriented surface and a soft-material brush mounted to the frame rearward of the vacuum member as defined by the direction of forward travel of the body-in-white. The apparatus may also include a vertical adjustment device(s) configured to adjust and maintain vertical distance between the apparatus relative to the associated vehicle. Also disclosed herein is a method for removing foreign material from an upwardly oriented surface of a body-in-white that comprises bringing the apparatus defined herein in proximate contact with at least one surface of a body-in-white as it progresses down a vehicle assembly line.

Abstract: A method and apparatus for removing foreign material from an upwardly oriented surface of a body-in-white. The apparatus includes a vacuum member mounted to a frame for removing foreign material from the associated upwardly oriented surface and a soft-material brush mounted to the frame rearward of the vacuum member as defined by the direction of forward travel of the vehicle. The apparatus may also vertical adjustment device(s) configured to adjust and maintain vertical distance between the apparatus relative to the associated vehicle. Also disclosed herein is a method for removing foreign material from an upwardly oriented surface of a body-in-white that comprises using bringing the apparatus defined herein in proximate contact with at least one surface of a body-in-white as it progresses down a vehicle assembly line.