Abstract: Pyrazolopyridinone compounds, the pharmaceutical compositions comprising said compounds, and the use of said compounds as FGFR (fibroblast growth factor receptor) inhibitors and their use in the treatment of diseases, e.g. cancer.

Abstract: The invention relates to new quinolinone compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds as FGFR (fibroblast growth factor receptor) inhibitors and to their use in the treatment of diseases, e.g. cancer.

Abstract: Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides pharmaceutical compositions, methods of preparing the crystalline compound, and methods of using the crystalline compound, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT or SGLT2 inhibition.

Abstract: Disclosed are substituted fused pyrazoles, for example substituted indazoles, that inhibit LRRK2 kinase activity, pharmaceutical compositions containing them and their use in the treatment of Parkinson's disease.

Abstract: An absorption rate in an absorbent article including a cell absorber is improved. The above-mentioned problem is solved by an absorbent article including an absorber having a plurality of cells surrounded by bonded portions of an upper sheet and a lower sheet, the upper sheet and the lower sheet not bonded at the cells, and a particulate material including super absorbent polymer particles contained in the cells, in which at least one of the upper sheet and the lower sheet in the cells is formed into concaves depressed to outsides of the cells in a spread state, a middle sheet made of a nonwoven fabric is interposed between the upper sheet and the lower sheet, and the middle sheet is compressed in a thickness direction at the bonded portions and expands to insides of the concaves at portions located inside the cells.

Abstract: A snow thrower includes a motor, an auger driven by the motor to rotate, a handle device for a user to operate, an auger housing for containing the auger and a frame for connecting the handle device and the auger housing. The auger housing is made of at least two different materials.

Abstract: The disclosed apparatus may include (1) a cage designed to house an optical transceiver module, wherein the cage includes (A) an entry side that forms an opening for installation and removal of the optical transceiver module and (B) a back side opposite the entry side and (2) an EMI absorber coupled to the back side of the cage to limit an amount of radiated energy that escapes the cage during operation of the optical transceiver module. Various other apparatuses, systems, and methods are also disclosed.

Abstract: The invention relates to methods for increasing nitrogen uptake, nitrogen assimilation, nitrogen use efficiency as well as yield in a plant, without affecting plant height, the method comprising increasing the expression or levels of a growth regulatory factor (GRF). Also described are genetically altered plants characterised by the above phenotype as well as methods of producing such plants.

Abstract: The invention relates to methods for increasing plant yield, and in particular grain yield by reducing or abolishing the expression and/or activity of OTUB1 in a plant. Also described are genetically altered plants characterised by the above phenotype and methods of producing such plants.

Abstract: The present disclosure provides a positive electrode plate and an electrochemical battery. The positive electrode plate comprises a positive electrode current collector and a positive electrode film. The positive electrode film is provided on the positive electrode current collector and comprises a positive electrode active material and a binder. The positive electrode active material comprises a prussian blue analogue material, the binder is an oil-soluble binder, an area density of the positive electrode film is 5 mg/cm2˜30 mg/cm2. In the positive electrode film of the present disclosure, the prussian blue analogue material is used together with the oil-soluble binder, and the area density of the positive electrode film is controlled within a certain range, so that introduction of the water molecule can be reduced during the preparation process and coating process of a positive electrode slurry, and cycle performance of the electrochemical battery can be improved.

Abstract: A snow thrower includes a motor, an auger driven by the motor to rotate, a handle device for a user to operate, an auger housing for containing the auger and a frame for connecting the handle device and the auger housing. The auger housing is made of at least two different materials.

Abstract: Provided are personal care compositions including (a) hydrophobic ester oil, (b) at least one of a nonionic or anionic surfactant, and (c) one or more polymers containing polymerized structural units of (i) 79 to 95.74 weight % of C4-C8 (meth)acrylate monomers, (ii) 0.5 to 5 weight % of (meth)acrylic acid monomer, (iii) 3.75 to 14 weight % of (methoxy) poly(ethylene glycol) methacrylates, and (iv) 0.01 to 2 weight % of at least one crosslinker.

Abstract: Provided are an engineered strain for synthesizing a dibasic organic acid and preparation and application of same. The engineered strain introduces or up-regulates expression of a positive regulator gene for synthesis of a dibasic organic acid, and/or down-regulates expression of a negative regulator gene for synthesis of a dibasic organic acid, as compared with the origin strain of the engineered strain, the producing capability for producing the dibasic organic acid is improved.

Abstract: A method for lightening skin tone is provided, comprising topically administering a personal care composition comprising: (A) voided latex particles comprising (i) a core polymer comprising (a) 20 to 60 weight % of monoethylenically unsaturated monomers containing a carboxylic acid group, and (b) 40 to 80 weight % of non-ionic ethylenically unsaturated monomers; and (ii) a shell polymer comprising (a) 55 to 85 weight % of non-ionic ethylenically unsaturated monomers, and (b) 15 to 45 weight % of polyethylenically unsaturated monomers; (B) 0.1 to 10 weight % of pigment grade inorganic metal oxide particles having a particle size of 250 nm to 1,000 nm; (C) a dermatologically acceptable carrier; and (D) an emollient, wherein the voided latex particles are present in at 0.5 to 10 weight %, based on weight of the composition, contain a void and have a particle size of 400 nm to 1500 nm.

Abstract: In described examples, a device mounted on a substrate includes an encapsulant. In at least one example, an encapsulant barrier is deposited along a scribe line, along which the substrate is singulatable. To encapsulate one or more terminals of the substrate, an encapsulant is deposited between the encapsulant barrier and an edge of the device parallel to the encapsulant barrier.

Abstract: The present disclosure provides a positive electrode plate, a preparation method thereof and a sodium-ion battery. The positive electrode plate comprises a positive electrode current collector and a positive electrode active material film. The positive electrode active material film provided on the positive electrode current collector and comprises a positive electrode active material. The positive electrode active material comprises a prussian blue analogue material, a molecular formula of the prussian blue analogue material is AxM[M?(CN)6]y, a water content of the positive electrode active material film is 100 ?g/g˜5000 ?g/g. The water content of the positive electrode active material film is controlled within a certain range, which can not only ensure the sodium-ion battery do not seriously swell during charge-discharge process, but also can ensure sodium-ion battery have excellent charge-discharge performance and cycle performance.

Abstract: Provided in the present invention are a phenylpropionate compound, a preparation method for same, and applications. The phenylpropionate compound has the structure as represented by formula I. The phenylpropionate compound of the present invention, a pharmaceutically acceptable salt, a solvate, a prodrug, and a tautomer or stereochemical isomer or pharmaceutical composition of the compound provide improved anti-inflammatory and antiplatelet effects and, at the same time, provide an extended time window for treatment, are free of obvious side effects, safe and effective, applicable in an antithrombus, anti-inflammatory, and cerebral stroke treating medicament, and have broad application prospects.

Abstract: A snow thrower includes a motor, an auger driven by the motor to rotate, a handle device for a user to operate, an auger housing for containing the auger and a frame for connecting the handle device and the auger housing. The auger housing is made of at least two different materials.

Abstract: A multistage colored polymer particle is provided, having a core comprising polymerized units of a monoethylenically unsaturated carboxylic acid core monomer and a non-ionic ethylenically unsaturated core monomer; an inner shell comprising polymerized units of a non-ionic ethylenically unsaturated inner shell monomer; a monoethylenically unsaturated carboxylic acid inner shell monomer; optionally, an aliphatic inner shell monomer; and, optionally, a first polymerizable dye monomer; an outer shell comprising polymerized units of a non-ionic ethylenically unsaturated outer shell monomer; a monoethylenically unsaturated non-carboxylic acid outer shell monomer; optionally, a second polymerizable dye monomer; and, optionally, an aliphatic outer shell monomer; wherein the core, when dry, contains at least one void; and wherein the multistage colored polymer particle comprises polymerized units of polymerizable dye monomer.

Abstract: An electric riding lawn mower includes a seat for a user to ride, a main frame to support the seat, a power output assembly including a mowing element to output power to realize mowing function and a first motor to drive the mowing element, a walking assembly to at least drive the electric riding lawn mower to travel in the direction of a first straight line on the ground and a second motor to drive the walking assembly, and a power supply device to power the electric riding lawn mower with a first battery pack, which includes a first battery pack housing and a plurality of battery cells disposed therein. The power supply device is mounted to the main frame. At least one of the first battery packs of the power supply device forms a pluggable connection with the main frame. The battery cells are lithium batteries.