Abstract: A fully human antibody targeting GPRC5D and a chimeric antigen receptor (CAR) comprising the fully human antibody. A host cell expressing the CAR, such as a CAR-T cell. A use of the fully human antibody, the CAR, and the CAR-T cell in treatment of tumors (such as multiple myeloma).

Abstract: An image display method applied to fields, including artificial intelligence (AI) and human computer interaction, includes detecting an input operation; displaying an image selection interface on a display in response to the input operation; determining at least one image related to the input operation from a group of associated images in a local memory or a cloud storage; displaying a thumbnail of the at least one image in the image selection interface; hiding another image; detecting a first operation where the first operation selects a first thumbnail in the image selection interface; and performing, on the first thumbnail, a processing procedure corresponding to the input operation.

Abstract: Compounds, compositions and methods for reducing off-target toxicity of T cells expressing a chimeric antigen receptor (CAR-T cells) and/or providing enhanced control of CAR-T cell activation, and methods of treating a subject and/or modifying CAR-T cell activity in a subject with cancer.

Abstract: The present disclosure provides the use of acetyltanshinone IIA in the preparation of medicament for treating lung cancer and medicament for treating lung cancer, which falls within the technical field of medicine. This protocol proposes the use of acetyltanshinone IIA in treating lung cancer, especially non-small cell lung cancer (NSCLC), which can antagonize primary and acquired drug resistance of NSCLC cells to epidermal growth factor receptor, tyrosine kinase inhibitor (EGFR TKIs), by using small molecule compound acetyltanshinone IIA. The present disclosure further identifies the molecular target of ATA and elucidates its mechanism of inhibiting the growth of drug-resistant NSCLC cells and tumors. The medicament containing acetyltanshinone IIA is expected to become a multi-target anticancer agent for treating TKI drug-resistant NSCLC.

Abstract: Disclosed are an airport control decision support system and method based on semantic recognition of a controller instruction. The system includes a speech acquisition module, a noise processing module, a speech recognition module, a semantic recognition module, a conflict recognition module, and an alarm display terminal. The system can effectively eliminate accidents and potential accidents thereof caused by human factors in a control process, and can improve safety of aircraft ground operation. Different from ordinary speech recognition and semantic recognition, data annotation of pronunciation and intonation is performed based on special pronunciation of air traffic control, and finally a speech database that conforms to airport control standard phrases is constructed. The airport control decision support system is implemented by installing a speech acquisition device and the alarm display terminal in a control seat, and thus the system is economical and practical.

Abstract: Disclosed are a method, device and system for tracking potential infected persons in a public place during an epidemic period. The method comprises: determining, according to associated information of a confirmed case, times of motions of the confirmed case in a public place and matching location information; searching for potential infected persons by means of video frame data provided by video monitoring devices in the public place based on an epidemic propagation mechanism; and tracking the potential infected persons based on multi-target tracking, and verifying the identity of the potential infected persons according to critical time nodes in the public place.

Abstract: Disclosed are an aircraft ground guidance system and method based on semantic recognition of a controller instruction. The system includes a semantic recognition module, a path generation and geographic information system (GIS) mapping module, and an aircraft guidance terminal module. The system can improve safety of aircraft ground operation, does not require manual operation of an aircraft guidance vehicle, can reduce construction, transformation, maintenance and operation costs, and meets airport control requirements, and a highly reliable, low-fault, economical and practical airport control decision support system and aircraft ground guidance system in an airport flight area are formed, improving the safety of aircraft ground operation.

Abstract: An image display method applied to fields, including artificial intelligence (AI) and human computer interaction, includes detecting an input operation; displaying an image selection interface on a display in response to the input operation; determining at least one image related to the input operation from a group of associated images in a local memory or a cloud storage; displaying a thumbnail of the at least one image in the image selection interface; hiding another image; detecting a first operation where the first operation selects a first thumbnail in the image selection interface; and performing, on the first thumbnail, a processing procedure corresponding to the input operation.

Abstract: The present invention discloses a selective hydrogenation catalyst and a preparation method and an application thereof, belonging to the technical field of catalysts. The selective hydrogenation catalyst comprises an active component and a carrier for supporting the active component, wherein the active component is a transition metal particle, the carrier is modified by a flexible chain ligand in advance, one end of the flexible chain ligand is uniformly distributed on the surface of the carrier, and the other end of the flexible chain ligand is coordinated on a transition metal. When the catalyst is used for catalytic hydrogenation reaction of dehydrolinalool or 2-methyl-3-butyn-2-ol, the stability is good, the catalyst still has high selectivity after being used for a long time, and the quality of a hydrogenation product can be guaranteed.

Abstract: The present invention discloses a selective hydrogenation catalyst and a preparation method and an application thereof, belonging to the technical field of catalysts. The selective hydrogenation catalyst comprises an active component and a carrier for supporting the active component, wherein the active component is a transition metal particle, the carrier is modified by a flexible chain ligand in advance, one end of the flexible chain ligand is uniformly distributed on the surface of the carrier, and the other end of the flexible chain ligand is coordinated on a transition metal. When the catalyst is used for catalytic hydrogenation reaction of dehydrolinalool or 2-methyl-3-butyn-2-ol, the stability is good, the catalyst still has high selectivity after being used for a long time, and the quality of a hydrogenation product can be guaranteed.

Abstract: A high-voltage n-channel high electron mobility transistor (HEMT) device is provided. In view of a relatively high process difficulty in preparing super junctions on heterojunction devices such as HEMT, the high-voltage n-channel HEMT device provides a surface super junction structure for an n-channel HEMT device. A comb-finger-shaped p-type semiconductor strip block is prepared on a surface of a drift region of the high-voltage n-channel HEMT device, and the p-type semiconductor strip block is electrically connected to a source electrode, so that large-range depletion of a channel of the drift region is realized under a turn-off condition, and a depletion region tolerates a high voltage, thus enhancing a breakdown characteristic of the high-voltage re-channel HEMT device.

Abstract: The present invention discloses a multi-needle bar module for sewing machines. Such a multi-needle bar module may be additionally mounted on the existing sewing machines, so that the existing sewing machines may be easily retrofitted into multi-needle bar sewing machines. The multi-needle bar module is not limited to a two-needle bar structure, and may be assembled with three, four or more needle bars according to actual requirements, solving the problem that both the single-needle bar sewing machines and the two-needle-bar sewing machines require manual change of threads in the process of sewing a pattern due to insufficient color varieties of the upper threads. The multi-needle-bar module guides each needle bar via the first horizontal guideway and the second horizontal guideway, and feeds a specific needle bar into the neck of the needle bar driving block via the driving mechanism. Such a multi-needle bar module has the advantages of simple structure and automatic control.

Abstract: Provided herein are fluorescent bioprobes comprising fluorogens that exhibit aggregation-induced emission (AIE) labeled on biomolecules. The present subject matter relates to a fluorescent bioprobe comprising one or more fluorogen labeled on chitosan. The present subject matter is also directed to methods of preparing the fluorescent bioprobes, methods of labeling and detecting DNA and/or proteins with the fluorescent bioprobe, and methods of cell imaging including live cell tracking.

Abstract: The present invention discloses a rubber band machine. The length of a rubber band to be conveyed may be set by controlling the angle of rotation of a first motor. The rubber band input by a first feeding drive wheel is stored between the first feeding drive wheel and a second feeding drive wheel so that the second feeding drive wheel coordinates with a looping device to continue to output the rubber band. During feeding, the rubber band machine can perform joint examination and ironing to the rubber band, and automatically cut the rubber band off at the discharge port of the second feeding drive wheel via a cutting device. The looping device grips the rubber band via a third gripper and moves rotationally to convey two ends of the rubber band to a first gripper and a second gripper, respectively.

Abstract: The present invention discloses a multi-needle bar module for sewing machines. Such a multi-needle bar module may be additionally mounted on the existing sewing machines, so that the existing sewing machines may be easily retrofitted into multi-needle bar sewing machines. The multi-needle bar module is not limited to a two-needle bar structure, and may be assembled with three, four or more needle bars according to actual requirements, solving the problem that both the single-needle bar sewing machines and the two-needle-bar sewing machines require manual change of threads in the process of sewing a pattern due to insufficient color varieties of the upper threads. The multi-needle-bar module guides each needle bar via the first horizontal guideway and the second horizontal guideway, and feeds a specific needle bar into the neck of the needle bar driving block via the driving mechanism. Such a multi-needle bar module has the advantages of simple structure and automatic control.

Abstract: Fluorescent bioprobes comprising luminogen formed nanoparticles comprising luminogens with aggregation-induced emission (AIE) properties, which can be used for long-term cell tracking. The luminogens are nonemissive in organic solution but become highly emissive when aggregated in aqueous solution. The fluorescent molecules can readily pass through cell membranes, stain only the cell cytoplasm, and form highly emissive nanoaggregates in aqueous media without any obvious cytoxicity in the living cells. Furthermore, the molecules can be retained inside the cells without noticeable leakage to the outside. Therefore, these AIE-based compounds can be used as selective and cell-compatible fluroescent bioprobes for long-term live cell tracking and imaging.

Abstract: The present invention relates to a method of preparing a solid form of soy isoflavone (e.g. genistein). In particular, the present invention relates to a method of preparing a solid form of soy isoflavone by precipitation with compressed antisolvent using a supercritical fluid to produce nano-sized particles of soy isoflavone with an improved dissolution rate and bioavailability. An oral composition or aerosolized formulation comprising the nanoparticles of the soy isoflavone prepared by the method of the present invention is also disclosed herein. The dissolution rate and bioavailability of the nanoparticles of the soy isoflavone prepared by the method of the present invention have a 2-fold increase and a 2.6-fold increase respectively as compared to those of the raw soy isoflavone.

Abstract: The present invention relates to the use of a compound of Formula I for the manufacture of a medicament for treating or preventing cancer in a subject.

Abstract: The present invention discloses a rubber band machine. The length of a rubber band to be conveyed may be set by controlling the angle of rotation of a first motor. The rubber band input by a first feeding drive wheel is stored between the first feeding drive wheel and a second feeding drive wheel so that the second feeding drive wheel coordinates with a looping device to continue to output the rubber band. During feeding, the rubber band machine can perform joint examination and ironing to the rubber band, and automatically cut the rubber band off at the discharge port of the second feeding drive wheel via a cutting device. The looping device grips the rubber band via a third gripper and moves rotationally to convey two ends of the rubber band to a first gripper and a second gripper, respectively.

Abstract: The invention relates to an enteric-coated capsule containing cationic nanoparticles for oral insulin delivery, in particular to a type of cationic nanoparticle including a polycationic and mucoadhesive polymer and a biodegradable polymer, wherein each of the nanoparticles has positive surface charge and enhanced permeability for paracellular insulin delivery; the enteric-coated capsule further includes a pH-sensitive polymer as the coating. The enteric-coated capsule containing cationic nanoparticles, when being orally administered to a subject, are configured to prevent the acidic degradation of the active substance such as insulin before being released from said cationic nanoparticles to a specific absorption site along the gastrointestinal tract.