Abstract: A compound having a BCL-XL protein degradation function as shown in Formula I and a use thereof in preparation of a drug for diseases associated with BCL-XL activity.

Abstract: An optical module includes a circuit board and a lens assembly. A light monitoring chip and a light emitting chip are arranged on the circuit board and covered by the lens assembly covers. The lens assembly is provided with: a first bevel forming a first preset angle for receiving a light signal emitted by the light emitting chip and splitting the light signal into a first split light and a second split light; a second bevel forming a second preset angle; a third bevel forming a third preset angle; a fourth bevel forming a fourth preset angle. The first split light may change its transmission direction of via cooperation of the first, second and the first preset angle, and is transmitted to a first optical fiber array. The second split light is transmitted to the light monitoring chip via cooperation of the fourth and first preset angle.

Abstract: Provided are a polypeptide derivative, modified derivative or salt thereof, and use of the polypeptide derivative, modified derivative or salt thereof, wherein the polypeptide derivative, modified derivative or salt thereof comprises a polypeptide having the sequence of following general formula I, general formula I: HX2QGTFTSDX10SX12YLX15X16X17X18AX20 EFX23X24WLX27X28X29X30X31, wherein the definitions of X2, X10, X12, X15, X16, X17, X18, X20, X23, X24, X27, X28, X29, X30 and X31 are consistent with the definitions in the claims and the description. The polypeptide derivative provided by the invention has a dual agonistic effect on GC/GLP-1 receptors, so that a synergistic effect on energy metabolism is generated, which can effectively reduce blood glucose while reducing body weight and improving the body fat level, and the efficacy is better than that of a single GLP-1 receptor agonist.

Abstract: A method, system, and computer program product are configured to: create a link tracing data structure in response to receiving a request from a user interface (UI), wherein the link tracing data structure includes a synchronization identifier and information about user actions in the UI; handle the request by calling plural microservices; add respective synchronization content for each one of the plural microservices to the link tracing data structure, wherein the respective synchronization content for a respective one of the plural microservices comprises: the synchronization identifier; a respective step identifier that identifies the respective one of the plural microservices; and a respective synchronization message that describes an execution status of the respective one of the plural microservices; store the link tracing data structure; and provide the link tracing data structure to a requesting user.

Abstract: A method, system, and computer program product for data reorganization and logs reorganization. The method includes receiving, by one or more processing units, original data. The method also includes classifying, by the one or more processing units, the original data into different types based on a trained type classification model. The method also includes generating, by the one or more processing units, at least one severity for at least part of the original data based on a trained severity classification model, the at least part of the original data corresponding to at least one type. The method also includes outputting, by the one or more processing units, at least one message, the at least one message indicating the severity of the at least part of the original data.

Abstract: Method, systems, and computer program products for access configuration in hybrid network environments are disclosed. According to the method, an access configuration request is received from a client device in a first network environment, wherein the access configuration request is associated with an access to a network resource in a second network environment and comprises first authentication information associated with the client device. Further, second authentication information associated with the network resource is obtained. The first and second authentication information is further used to determine whether the access configuration request is verified. If the access configuration request is verified, connectivity between the client device and the network resource can be automatically established.

Abstract: A magnetic resonance imaging (MRI) contrast agent and a preparation method and a use thereof is provided, which belong to the technical field of Magnetic Resonance Imaging contrast agent. The MRI contrast agent is prepared by the compound having a structure of formula I; and it also may include the compound having a structure of formula II or a pharmaceutically acceptable salt thereof, wherein M1 is a divalent ion or a trivalent ion of a paramagnetic metal selected from Mn, Fe, Eu, or Dy; M2 is selected from Na+, K+ or meglumine cation; when M1 is a divalent ion, a is 2; when M1 is a trivalent ion, a is 3. The MRI contrast agent has good water solubility, high relaxivity, and low toxic and side effect.

Abstract: A method, system, and computer program product for data reorganization and logs reorganization. The method includes receiving, by one or more processing units, original data. The method also includes classifying, by the one or more processing units, the original data into different types based on a trained type classification model. The method also includes generating, by the one or more processing units, at least one severity for at least part of the original data based on a trained severity classification model, the at least part of the original data corresponding to at least one type. The method also includes outputting, by the one or more processing units, at least one message, the at least one message indicating the severity of the at least part of the original data.

Abstract: The present application provides a method and an apparatus of modulating a neuronal firing frequency at a brain functional site in a brain, the method comprising: generating an electromagnetic field with its power in variation at the preset modulating frequency; and arranging the generated electromagnetic field near the brain such that the brain functional site is within the range of the near field of the electromagnetic field, to polarize extracellular fluid at the brain functional site with the power of the electromagnetic field, such that a polarization density of the extracellular fluid varies at the preset modulating frequency and neurons in the extracellular fluid are modulated to fire at the preset modulating frequency.

Abstract: The present application provides a method and an apparatus of actively sensing a neuronal firing frequency at a functional site in a brain, the method comprising: generating a varying electromagnetic field and acting a near field of the generated electromagnetic field on a targeted brain functional site; sensing the alteration of the electromagnetic field at the targeted brain functional site; and determining a variation frequency of the alteration of the electromagnetic field at the targeted brain functional site as the neuronal firing frequency at the targeted brain functional site.

Abstract: The present disclosure herein discloses a method for analyzing a relationship between a communication path and heat resistance of lipase, and belongs to the technical field of computer application.

Abstract: The present invention presents methods and apparatus for detecting, imaging, monitoring, and modulating of brain activities and neuronal activities in the brain using radiofrequency (RF) electromagnetic (EM) waves, as well as methods and apparatus for detecting, imaging, and monitoring breathing and heart-beating using RF EM waves.

Abstract: Disclosed is a system for monitoring activities of Autonomic Nervous System (ANS) for preventive medicine comprising: a sensing device configured to sense an involuntary control signal from the ANS of a subject in sleep; and an analyzing device configured to analyze the sensed involuntary control signal received from the sensing device to evaluate a dynamic health condition of the subject, and output the evaluated dynamic health condition.

Abstract: Embodiments of the present disclosure relate to a method for closing a plurality of webpages in a browser. According to the method, one or more records are acquired in response to receiving an instruction to close a first webpage. Each record comprises at least two URLs having a parent-child relationship. A URL chain of the first webpage is acquired based on the acquired one or more records in response to receiving an instruction to close a plurality of webpages related to the URL chain. The URL chain consists of a plurality of URLs having a multi-level parent-child relationship. The plurality of webpages related to the URL chain are closed.

Abstract: Embodiments of the present disclosure relate to a method for closing a plurality of webpages in a browser. According to the method, one or more records are acquired in response to receiving an instruction to close a first webpage. Each record comprises at least two URLs having a parent-child relationship. A URL chain of the first webpage is acquired based on the acquired one or more records in response to receiving an instruction to close a plurality of webpages related to the URL chain. The URL chain consists of a plurality of URLs having a multi-level parent-child relationship. The plurality of webpages related to the URL chain are closed.

Abstract: A method and apparatus manage a sleep mode of a brain by measuring a sleep depth as well as a sleep stage of the brain in the sleep mode. A damping/blocking level of a reticular formation is measured in descending motor cortex-emitted idle impulses to at least one part of a body.

Abstract: The present application provides a method and an apparatus of modulating a neuronal firing frequency at a brain functional site in a brain, the method comprising: generating an electromagnetic field with its power in variation at the preset modulating frequency; and arranging the generated electromagnetic field near the brain such that the brain functional site is within the range of the near field of the electromagnetic field, to polarize extracellular fluid at the brain functional site with the power of the electromagnetic field, such that a polarization density of the extracellular fluid varies at the preset modulating frequency and neurons in the extracellular fluid are modulated to fire at the preset modulating frequency.

Abstract: The present application provides a method and an apparatus of actively sensing a neuronal firing frequency at a functional site in a brain, the method comprising: generating a varying electromagnetic field and acting a near field of the generated electromagnetic field on a targeted brain functional site; sensing the alteration of the electromagnetic field at the targeted brain functional site; and determining a variation frequency of the alteration of the electromagnetic field at the targeted brain functional site as the neuronal firing frequency at the targeted brain functional site.

Abstract: A neural physiological method and apparatus for keeping the brain in wakefulness, in which the trigeminal nerves on the forehead are stimulated with a mild electrical current neuronal modulating signal of a range of frequencies and amplitudes in combination transmitted to the brain functional site locus coeruleus, resulting in inhabitation of the brain functional site thalamic reticular nucleus such that the thalamic reticular nucleus does not release inhibitory neurotransmitters for blocking the communication pathways between the thalamus and the cortical regions in the brain, keeping the brain in wakefulness.