Patents by Inventor Qian Ye

Qian Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12125161
    Abstract: The present disclosure provides techniques for automatically modifying shape features related to overhangs such that support structures can be reduced or avoided. In an example, a shape modification processing device may obtain an initial shape and relevant production information (e.g., overhang angle threshold). The shape modification processing device may modify the shape to improve various aspects of production, including reduction or removal of the need for support materials or structures during additive manufacturing, with considerations that allow the modified portion (e.g., added features) be accessible for removal by subtractive manufacturing. For example, the shape modification processing device may modify a model to reduce or remove support structures needed during production. The added features may later be removed by subtractive manufacturing to restore any functional or desired shape.
    Type: Grant
    Filed: April 7, 2022
    Date of Patent: October 22, 2024
    Assignee: Xerox Corporation
    Inventors: Qian Ye, Matt Patterson, Amirmassoud Mirzendehdel, Morad Behandish
  • Publication number: 20230394191
    Abstract: This disclosure provides techniques for automatically generating a geometric representation based on a system-level model (e.g., a lumped parameter model, or LPM). The geometric representation may include a three-dimensional (3D) or cross-sectional shape, resulting from topology optimization within a design space automatically generated without human intervention. An example method may include identifying one or more constraints for each of two or more components of an LPM. One or more conditions are generated for the LPM. The one or more conditions are mapped to the one or more constraints. A processing device may generate a design space for a geometric representation to perform functions represented by the LPM. The geometric representation is subject to the generated one or more conditions. The processing device may then perform topology optimization of the geometric representation in the design space to generate an optimized geometry (e.g., a converged and/or final output).
    Type: Application
    Filed: June 2, 2022
    Publication date: December 7, 2023
    Inventors: Randi Wang, Anurag Bhattacharyya, Qian Ye, Clinton Morris, Amirmassoud Mirzendehdel, Morad Behandish
  • Publication number: 20230355759
    Abstract: Provided herein are populations of placental-derived natural killer cells comprising a cleavage resistant CD16. Also provided are methods of treating diseases, disorders or conditions in a human subject comprising administering to the subject an effective amount of a population of placental-derived natural killer cells comprising a cleavage resistant CD16 to the subject so as thereby to provide an effective treatment of the to the subject. The cells, such as CYNK cells, can be placental CD34+ cell-derived natural killer (NK) cells. The diseases, disorders or conditions include cancers such as multiple myeloma and lymphoma. The present invention also provides compositions comprising populations of placental-derived natural killer cells comprising a cleavage resistant CD16 for the treatment of a subject and methods of their use.
    Type: Application
    Filed: July 31, 2020
    Publication date: November 9, 2023
    Applicant: CELULARITY INC.
    Inventors: Xuan GUO, Srinivas SOMANCHI, Rohit MATHUR, Shuyang HE, Qian YE, Xiaokui ZHANG, Salvatore ROTONDO, Hemlata RANA, Weifang LING, James W. EDINGER, Robert J. HARIRI, Andrea DIFIGLIA
  • Publication number: 20230326155
    Abstract: The present disclosure provides techniques for automatically modifying shape features related to overhangs such that support structures can be reduced or avoided. In an example, a shape modification processing device may obtain an initial shape and relevant production information (e.g., overhang angle threshold). The shape modification processing device may modify the shape to improve various aspects of production, including reduction or removal of the need for support materials or structures during additive manufacturing, with considerations that allow the modified portion (e.g., added features) be accessible for removal by subtractive manufacturing. For example, the shape modification processing device may modify a model to reduce or remove support structures needed during production. The added features may later be removed by subtractive manufacturing to restore any functional or desired shape.
    Type: Application
    Filed: April 7, 2022
    Publication date: October 12, 2023
    Inventors: Qian Ye, Matt Patterson, Amirmassoud Mirzendehdel, Morad Behandish
  • Publication number: 20230310319
    Abstract: Several approaches to produce, isolate, and characterize exosomes recovered from a cultivated placenta or a portion thereof are provided. The alternatives described herein facilitate the production, isolation, and characterization of exosomes, which can be used as biotechnological tools and therapeutics. Also provided herein are populations of exosomes derived from placenta organ culture or culture of portions of the placenta. Also provided are compositions comprising the populatons of exosomes and methods of their use for the treatment of subjects.
    Type: Application
    Filed: June 2, 2023
    Publication date: October 5, 2023
    Applicant: Celularity Inc.
    Inventor: Qian YE
  • Patent number: 11723930
    Abstract: Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: August 15, 2023
    Inventors: James W. Edinger, Robert J. Hariri, Jia-Lun Wang, Qian Ye, Herbert Faleck
  • Publication number: 20230210909
    Abstract: Provided herein are methods of using CD10+, CD34?, CD105+, CD200+ tissue culture plastic-adherent placental cells, e.g. placental stem cells, in the treatment of SARS-CoV-2 related acute respiratory failure and ARDS (COVID-19).
    Type: Application
    Filed: May 10, 2021
    Publication date: July 6, 2023
    Applicant: Celularity Inc.
    Inventors: Robert J. HARIRI, Xiaokui ZHANG, Shuyang HE, Kathy KARASIEWICZ-MENDEZ, Qian YE, Tanel MAHLAKOIV, Stacy HERB, Corey CASPER
  • Publication number: 20230181649
    Abstract: The present invention provides method of treating diseases, disorders and conditions in a human subject comprising administering to the subject a population of exosomes or a composition comprising a population of exosomes, wherein said population of exosomes is positive for CD1c, CD20, CD24, CD25, CD29, CD2, CD3, CD8, CD9, CD11c, CD14, CD19, CD31, CD40, CD41b, CD42a, CD44, CD45, CD49e, CD4, CD56, CD62P, CD63, CD69, CD81, CD86, CD105, CD133-1, CD142, CD146, CD209, CD326, HLA-ABC, HLA-DRDPDQ, MCSP, ROR1, SSEA-4, or combinations thereof. Such diseases, disorders and conditions include lung, liver, central nervous system, kidney, cardiovascular, gastrointestinal, spleen, eye, systemic and ageing associated diseases, disorders, and conditions.
    Type: Application
    Filed: June 19, 2020
    Publication date: June 15, 2023
    Applicant: Celularity Inc.
    Inventors: Robert J. HARIRI, Xiaokui ZHANG, Qian YE, Bhavani STOUT, Haley M. HARIRI, Navjot SHAH, Srinivas Somanchi, Shuyang He
  • Patent number: 11579158
    Abstract: An automatic human urine detection system comprises a control module, a urine collection module, a detection module, an output module and a cleaning module. The control module controls operation of the system and comprises an instruction input unit. The urine collecting module is used for collecting urine to be detected; the detection module comprises a detection probe holder which is used for detecting the urine to be collected and obtains a corresponding detection report according to a detection result; the output module is used for outputting the detection report; and the cleaning module is used for cleaning system components through which the urine flows or is stored in the system. The automatic human urine detection system integrates automatic collection and subsequent automatic detection of human urine, the whole urinalysis process is effectively simplified, the operation process is humanized, and the user experience is good.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: February 14, 2023
    Assignee: ZHEJIANG DEYEETEC MEDICAL TECHNOLOGY CO., LTD.
    Inventor: Zhi Qian Ye
  • Publication number: 20220348875
    Abstract: Provided herein are genetically modified (GM) natural killer (NK) cells and methods of producing populations of GM NK cells. Further provided herein are methods of using the GM NK cells described herein, to, e.g., suppress the proliferation of tumor cells, or to inhibit pathogen infection, e.g., viral infection. In certain alternatives, GM NK cells provided herein lack expression of CBLB, NKG2A and/or TGFBR2 and/or function or show reduced expression and/or function of CBLB, NKG2A and/or TGFBR2. In certain alternatives, GM NK cells provided herein comprise modified CD16.
    Type: Application
    Filed: December 17, 2021
    Publication date: November 3, 2022
    Applicant: Celularity Inc.
    Inventors: Xiaokui Zhang, Qian Ye, Tianjian Li, Chuan Wang, Mini Bharathan, Uri Herzberg, Robert J. HARIRI
  • Publication number: 20220160787
    Abstract: The present invention provides an isolated non-human placenta derived stem cell, wherein the stem cell expresses CD90 or wherein the stem cell expresses CD29. The present invention also provides a composition comprising an isolated non-human placenta derived stem cell of the invention or a population of isolated non-human placenta derived stem cells of the invention, and a carrier. The present invention also provides a composition of the invention for use in the manufacture of a medicament to reduce the incidence of rejection in a patient receiving a xenotransplant form a non-human donor. The present invention provides a method of treating a subject receiving a xenotransplant or xenotransfusion comprising the step of administering to the patient an effective amount of a non-human placenta derived stem cells.
    Type: Application
    Filed: March 16, 2020
    Publication date: May 26, 2022
    Applicant: Celularity Inc.
    Inventors: QIAN YE, Joseph GLEASON, Lin KANG, Robert J. HARIRI, Shuyang HE, Xiaokui ZHANG, Valentina ROUSSEVA
  • Publication number: 20220096352
    Abstract: The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal.
    Type: Application
    Filed: May 13, 2021
    Publication date: March 31, 2022
    Applicant: Celularity Inc.
    Inventors: Mohit B. BHATIA, Chris LUGO, Qian YE, James W. EDINGER
  • Publication number: 20220096564
    Abstract: Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.
    Type: Application
    Filed: May 13, 2021
    Publication date: March 31, 2022
    Applicant: Celularity Inc.
    Inventors: James W. EDINGER, Robert J. HARIRI, Jia-Lun WANG, Qian YE, Kristen S. LABAZZO, Marian PEREIRA, Sasha Dawn ABRAMSON
  • Publication number: 20210221854
    Abstract: This disclosure describes a system for generating influenza virus or influenza virus proteins, methods of making that system, and methods of using that system.
    Type: Application
    Filed: January 15, 2021
    Publication date: July 22, 2021
    Inventors: Wei-Shou Hu, Thu Phan, Christopher S. Stach, Ryan A. Langlois, Qian Ye
  • Publication number: 20210145872
    Abstract: Provided herein are methods for forming three-dimensional tissues in vivo. In one embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells. In another embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells and at least one composition that comprises an extracellular matrix (ECM). In another embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells, at least one composition that comprises an extracellular matrix (ECM), and at least one other additional components.
    Type: Application
    Filed: June 23, 2020
    Publication date: May 20, 2021
    Applicant: Celularity Inc.
    Inventors: Robert J. HARIRI, Mohit B. BHATIA, Wolfgang HOFGARTNER, Jia-Lun WANG, Qian YE
  • Publication number: 20210018525
    Abstract: An automatic human urine detection system comprises a control module, a urine collection module, a detection module, an output module and a cleaning module. The control module controls operation of the system and comprises an instruction input unit. The urine collecting module is used for collecting urine to be detected; the detection module comprises a detection probe holder which is used for detecting the urine to be collected and obtains a corresponding detection report according to a detection result; the output module is used for outputting the detection report; and the cleaning module is used for cleaning system components through which the urine flows or is stored in the system. The automatic human urine detection system integrates automatic collection and subsequent automatic detection of human urine, the whole urinalysis process is effectively simplified, the operation process is humanized, and the user experience is good.
    Type: Application
    Filed: July 9, 2020
    Publication date: January 21, 2021
    Inventor: Zhi Qian YE
  • Publication number: 20200397830
    Abstract: Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
    Type: Application
    Filed: January 24, 2020
    Publication date: December 24, 2020
    Applicant: CELULARITY, INC.
    Inventors: James W. Edinger, Robert J. Hariri, Jia-Lun Wang, Qian Ye, Herbert Faleck
  • Publication number: 20200246385
    Abstract: Provided herein are micro-organoids, referred to herein as Functional Physiological Units (FPUs), that are capable of replacing or augmenting one or more physiological functions in an individual, which are useful in the treatment of individuals lacking, or suffering a deficit in, said physiological function.
    Type: Application
    Filed: April 21, 2020
    Publication date: August 6, 2020
    Applicant: Celularity Inc.
    Inventors: Robert J. HARIRI, Mohit BHATIA, Jia-Lun WANG, Wolfgang HOFGARTNER, Qian YE
  • Patent number: 10622507
    Abstract: A nitride underlayer includes: a pattern substrate with lattice planes of different growth rates; a nitride nucleating layer over the pattern substrate; a first nitride layer with three-dimensional growth over the nitride nucleating layer, and forming a nanopillar structure at a top of the substrate; a second nitride layer with two-dimensional growth over the first nitride layer, and folding into an uncracked plane over the nanopillar structure.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: April 14, 2020
    Assignee: XIAMEN SANAN OPTOELECTRONICS TECHNOLOGY CO., LTD.
    Inventors: Da-qian Ye, Dongyan Zhang, Chaoyu Wu, Duxiang Wang
  • Patent number: D938511
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: December 14, 2021
    Assignee: Wenzhou Yijie Trading Co., Ltd.
    Inventor: Qian Ye