Abstract: An active energy-absorbing shock absorber for perforation combined well testing includes a first energy-absorbing mechanism, a second energy-absorbing mechanism and an axial-force cushioning mechanism. The first energy-absorbing mechanism includes a gun body, a gun head, a gun tail joint, a support frame, an energy-absorbing filling layer and a detonation mechanism. The second energy-absorbing mechanism includes an intermediate connecting cylinder, an outer cylinder, a limiting step, a movable impact head, a support base, a hydraulic buffer mechanism, a piston rod, an energy-absorbing spring and an inner cavity piston. The axial-force cushioning mechanism includes a housing, a guide mechanism, a buffer shaft and a multi-stage buffer spring. The absorber with a multi-layer structure is filled with a foam aluminum material.

Abstract: The present application provides compounds as shown in Formula (I) and uses thereof. The compounds shown in Formula (I) provided by the present application may serve as effective glucagon-like peptide-1 (GLP-1) receptor agonists. They have excellent GLP-1R receptor agonist activity and significant blood glucose-reducing effect, have better pharmacokinetic characteristics, represent more options for the prevention and/or treatment of GLP-1 activity-related diseases, conditions, or disorders, and thereby have better clinical application prospects.

Abstract: Provided is an organic electroluminescent device. The organic electroluminescent device comprises an anode, a cathode, and a first organic layer and a second organic layer disposed between the anode and the cathode, where the first organic layer comprises a first compound represented by Formula 1, and the second organic layer comprises a second compound represented by Formula 2 or Formula 3 and a third compound represented by Formula 4. The first compound can be used as an electron blocking material in the organic electroluminescent device, and the second compound and the third compound can be used as dual host materials in the organic electroluminescent device. The electroluminescent device is capable of maintaining a low voltage or further reducing the device voltage and improving device efficiency and lifetime, thereby improving the overall performance of the device. Further provided is an electronic device including the organic electroluminescent device.

Abstract: The present invention relates to an N-substituted phenylsulfonamide compound and a use thereof. Specifically, the present invention provides a compound represented by formula I, or an optical isomer thereof, or a racemate thereof, or a pharmaceutically acceptable salt thereof. The compound described in the present invention has an excellent inhibitory effect on transient receptor potential channel proteins, and has an excellent therapeutic effect on transient receptor potential channel protein-related diseases, such as inflammatory bowel disease, irritable bowel syndrome, pain, and inflammation.

Abstract: Provided herein are novel conjugates of TGF-beta inhibitors and bisphosphonates, pharmaceutical compositions comprising the conjugates, methods of preparing the conjugates, and methods of using the conjugates, for example, for the treatment of a bone disease or disorder, such as osteoarthritis.

Abstract: Provided herein are novel compounds (e.g., Formula I or II), pharmaceutical compositions, and methods of using related to Tyrosine kinase 2 (TYK2). The compounds herein are typically TYK2 inhibitors, which can be used for treating a variety of diseases or disorders, such as an autoimmune disorder or an inflammatory disorder, e.g., psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis, inflammatory bowel disease, and/or systemic lupus erythematosus.

Abstract: The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to compounds with ALK inhibitory activity and preparation method and use thereof. The compounds with ALK inhibitory activity provided by the present application are ALK inhibitors for treating diseases responsive to the inhibition of ALK kinase, can be used for treating ALK-positive diseases, such as tumors and cancers, and have broad application prospects.

Abstract: A tunnel tunneling system includes a bolter miner, a bolter-integrated transportation machine, a transfer machine, a self-moving tail and a belt conveyor. The bolter miner includes a rack, a cutting device, a drilling device and a control device. The cutting device is arranged on the rack and is swingable in an up-down direction, and has a lowest swing angle and a highest swing angle. The drilling device is arranged on the rack, and includes a drilling rig and a sensor. The drilling rig is configured to drill a tunnel floor and/or a tunnel roof, and the sensor is configured to monitor a set parameter of the drilling rig and generate a monitoring data signal when the drilling rig is drilling. The control device is configured to receive and analyze the monitoring data signal.

Abstract: Provided herein are novel compounds (e.g., Formula I or II), pharmaceutical compositions, and methods of using related to cyclin dependent kinases (CDKs). The compounds herein are typically CDK2 inhibitors, which can be used for treating a variety of diseases or disorders, such as cancer.

Abstract: A method for storing video data includes, when receiving the I-frame data to be stored, detecting whether the written data exists in the video cache space; when detecting that the written data exists in the video cache space, reading a target writing position of the I-frame data to be stored and determining whether the target writing position is located within a position range corresponding to the written data in the first cache space; when determining the target writing position is located within the position range, writing, based on the target writing position, the I-frame data to be stored to the first cache space for caching and detecting whether the first cache space is full; and when detecting that the first cache space is full, writing all the video data in the video cache space to a memory space of the terminal device for storage and emptying the video cache space.

Abstract: A medical dental grinding apparatus comprises an apparatus body, wherein an air pipeline, a clamping mechanism, and a grinding mechanism are provided in the apparatus body; the air pipeline includes an air inlet pipeline, an air outlet pipeline, and a U-shaped connection pipeline; a silencer is connected to an upper port of the air outlet pipeline; a plane where the air pipeline is located is perpendicular to a plane where the clamping mechanism is located, and the grinding mechanism is provided below the air pipeline; the grinding mechanism is driven by high-pressure air in the air pipeline to operate, so that a hidden danger of electric leakage caused by using an electric apparatus in a fragile oral environment is avoided; and a steel wire is fixed by the clamping mechanism, so that the grinding safety is ensured.

Abstract: A method for checking a medium-term and long-term maintenance plan of a power grid. A predicted load value and one or more historical load values of a power grid are acquired and clustered through a clustering algorithm, and a historical moment at which a historical load value is in a same cluster as the predicted load value and has a largest load value is selected as a target historical moment. A power grid operation mode model at the target historical moment is acquired, and the power grid operation mode model is updated according to the maintenance plan and open loop point information by using a full wiring approach to obtain a future-state power grid operation mode model. Ground state power flow data of the power grid are calculated based on the operation mode model, and safety check is carried out according to a preset ground state power flow limit.

Abstract: Provided are a compound as represented by formula I, a preparation method therefor, and a hydrochloride crystal form A thereof. The compound as represented by formula I and the hydrochloride crystal form A thereof have excellent inhibitory effects on transient receptor potential (TRP) channels, and have good therapeutic effects on TRP channel-associated diseases.

Abstract: The present disclosure provides a single or multi-coupled fault test system and fault diagnosis method for a rotor system. With the modular design, and by setting different rotating conditions and structural forms of the flexible rotor system for simulation on operation states and fault types of the rotor system, the present disclosure can implement the simulation test of the rotor system in different fault conditions and can ensure the accuracy of the test performance in the simulation test. With the establishment of the fault determination models of the rotor system in the different fault conditions, the present disclosure can accurately predict and warn the fault of the rotor system, accurately analyze the fault type, and ensure the operational reliability of the rotor system.

Abstract: The present invention relates to a recombinant strain for producing shikimic acid, in which a target gene that regulates the asymmetric cell division and target genes that regulate the shikimic acid production are expressed The target gene that regulates the asymmetric cell division includes cytoskeletal protein PopZ coding gene popZ, and the target genes that regulate the shikimic acid production include DAHP synthase coding gene aroG, 3-dehydroquinate synthase coding gene aroB, and transketolase coding gene tktA. The recombinant strain of the present invention realizes the de novo synthesis of shikimic acid using glucose as a substrate, with a low cost. After fermentation with the strain in a 7.5 L fermentor, the highest production of shikimic acid is 88.1 g/L, the yield is 0.33 g/g, and the production intensity of shikimic acid is 1.1 g/L/h.

Abstract: Disclosed is a radial fault simulation test system for rotary mechanical equipment. The system comprises a simulation test bed, a data collection system and a control system, wherein the data collection system is used for collecting the operation state data of a rotating shaft; and the control system is used for receiving the data collected by the data collection system, analyzing and processing the data, and controlling the simulation test bed according to an analysis result. The system adopts a modular design, can simulate the operation state and the fault type of the rotary mechanical system under different rotation conditions and structural forms, can realize a simulation test of the rotary mechanical system under different fault states, and can preferably ensure the accuracy of the test performance of the simulation test.

Abstract: A component of a kinetic sculpture is provided which comprises a bearing unit (400), a column (100) vertically disposed on the bearing unit (400) and a blade unit (200) disposed on the column (100); the blade unit (200) comprises a plurality of blade groups spaced apart along an axial direction of the column (100), the blade group comprises one or more movable blades (201-S), and a blade driving unit (300) for driving the movable blades (201-S) in a same blade group to freely switch between a gathered state and a separated state is disposed on the column (100).

Abstract: A method for storing video data includes, when receiving the I-frame data to be stored, detecting whether the written data exists in the video cache space; when detecting that the written data exists in the video cache space, reading a target writing position of the I-frame data to be stored and determining whether the target writing position is located within a position range corresponding to the written data in the first cache space; when determining the target writing position is located within the position range, writing, based on the target writing position, the I-frame data to be stored to the first cache space for caching and detecting whether the first cache space is full; and when detecting that the first cache space is full, writing all the video data in the video cache space to a memory space of the terminal device for storage and emptying the video cache space.

Abstract: A 3-aryloxyl-3-five-membered heteroaryl propylamine compound, and crystal form and use thereof are provided. Specifically, a compound, or a pharmaceutically acceptable salt or a prodrug thereof, the compound having a structure of formula I is described. The compound, or pharmaceutically acceptable salt or prodrug thereof has an excellent inhibition function for a transient receptor potential channel protein (TPR), and has a good treatment function for diseases associated with the TPR.