Abstract: Antibody-drug conjugates (ADC) useful for preventing, treating, and/or acting as an adjuvant in treating c-MET and/or EGFR-related diseases are disclosed. The ADCs comprise a bispecific antibody or antigen-binding fragment thereof comprising an arm specific for binding to EGFR and an arm specific for binding to c-MET conjugated to a cytotoxic drug.

Abstract: A hinge mechanism includes a base, a first rotation component, and a second rotation component, and the first rotation component and the second rotation component are disposed on two sides of the base respectively. The first rotation component includes a first support arm, a first rotation plate, a first pin shaft, and a first torsion spring. The first support arm is rotatably coupled to the base. A first side of the first rotation plate is rotatably coupled to the first support arm via the first pin shaft. The first torsion spring is sleeved on the first pin shaft, a first torsion arm of the first torsion spring is fastened to the first support arm, and a second torsion arm of the first torsion spring abuts against the first side of the first rotation plate.

Abstract: A polymorph of a reduced ?-nicotinamide mononucleotide disodium salt, and a preparation method therefor and the use thereof as a pharmaceutical ingredient, a healthcare product ingredient, a cosmetic ingredient, or a food additives, and a preparation containing the salts are provided. A polymorph of NMNH disodium salt has excellent solubility, stability, flow performance, and hygroscopicity resistance. Its purification effects is better than that of amorphous forms.

Abstract: The invention relates to an optoelectronic device including a light-emitting layer, the light-emitting layer including (i) a host material, and (ii) an organic molecule including a structure of Formula I: wherein RX is selected from the group consisting of: a halogen group; a cyano group; a substituted or unsubstituted alkyl group; a substituted or unsubstituted alkynyl group; a substituted or unsubstituted alkoxy group; a substituted or unsubstituted alkenyl group; a substituted or unsubstituted silyl group; a substituted or unsubstituted aryloxy group; a substituted or unsubstituted aryl group; a substituted or unsubstituted heterocyclic group; and a substituted or unsubstituted hydrocarbon ring group.

Abstract: Provided are a method for constructing a transverse audible noise model for an electric transmission corridor, a microphone support apparatus, and an audible noise measurement device.

Abstract: A foldable electronic device and a hinge mechanism thereof are provided. In addition to the hinge mechanism, the electronic device further includes two housings and a flexible display. The two housings are respectively disposed on two opposite sides of the hinge mechanism and are rotatably connected to the hinge mechanism. The hinge mechanism includes a base and a main shaft module. The base includes a bearing surface. The main shaft module includes two rotating assemblies. The two rotating assemblies are disposed on two opposite sides of the base. Each rotating assembly includes a swing arm and a housing fastening bracket, and each housing fastening bracket may be fastened to a housing on a corresponding side. In an unfolded state, the bearing surface independently supports a foldable portion of the flexible display. In a folded state, a screen accommodation space is formed between the two housing fastening brackets and the base.

Abstract: A foldable mounting device for a photographing device includes a base plate, a side plate, and a locking member. The base plate includes a connecting end defining an accommodation slot and a connecting opening. The connecting opening passes through a side of the base plate, the accommodation slot includes a slot opening passing through another side of the base plate. The side plate is connected to the connecting end. The locking member slidably received in the accommodation slot includes a locking part and an operation part. The operation part is received in the slot opening. The locking member is operatable to move from a locked state in which the locking part passes through the connecting opening to engage with the side plate to an unlocked state in which the locking part is disengaged from the side plate and the side plate is rotatable relative to the base plate.

Abstract: A cutting insert comprising a variable function cutting edge wherein said cutting edge has a variable cutting edge height along a length of said cutting edge. This invention further provides a cutting insert comprising a cutting edge having a nose and a depth of cut location, and wherein the cutting edge has a generalized first height, and wherein the cutting edge of the depth of cut location has a second height, and wherein the cutting edge of the nose has a third height, and wherein the second height of the cutting edge of the depth of cut location is smaller than the third height of the cutting edge of the nose of the cutting insert.

Abstract: An example sensor includes a flow cell, a detection device, and a controller. The flow cell includes a passivation layer having opposed surfaces and a reaction site at a first of the opposed surfaces. The flow cell also includes a lid operatively connected to the passivation layer to partially define a flow channel between the lid and the reaction site. The detection device is in contact with a second of the opposed surfaces of the passivation layer, and includes an embedded metal layer that is electrically isolated from other detection circuitry of the detection device. The controller is to ground the embedded metal layer.

Abstract: The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.

Abstract: Disclosed herein are anti-MASP-2 antibodies and antigen-binding fragments, polynucleotides encoding the antibodies and antigen-binding fragments, and pharmaceutical compositions comprising the antibodies and antigen-binding fragments. Uses of the anti-MASP-2 antibodies and antigen-binding fragments described herein in treatment of conditions and disorders associated completement activation are also disclosed.

Abstract: The present disclosure relates to a touch panel and a touch display panel. The touch panel includes: a substrate including a front surface, including first and second directions that intersect with each other; first touch electrodes extending in the first direction and arranged in the second direction are disposed on the front surface, the first touch electrode includes first sub electrodes, and adjacent first sub electrodes are electrically connected to each other via a connecting member; second touch electrodes extending in the second direction and arranged in the first direction are further on the front surface, the second touch electrode includes second sub electrodes, and adjacent second sub electrodes are electrically connected to each other via a bridging member; the connecting member partially overlaps with the bridging member and is insulated from the bridging member; the bridging member is provided with at least one transparent hole penetrating the bridging member.

Abstract: A scene flow estimation method includes: inputting a frame pair into an artificial intelligence (AI) network, and obtaining therefrom a motion embedding feature and a non-occluded-category label embedding feature corresponding to a target pixel in the frame pair; and estimating a scene flow corresponding to the frame pair based on the motion embedding feature and the non-occluded-category label embedding feature, the frame pair includes a first frame and a second frame, the first frame including a first color image and a first depth image and the second frame including a second color image and a second depth image, the non-occluded-category label embedding feature includes category information of an object corresponding to a pixel pair in the frame pair, the pixel pair includes a first pixel of the first frame and a second pixel of the second frame, and the second pixel corresponds to the first pixel.

Abstract: Glass-ceramic containers and methods of making glass ceramic containers with high transparency and fracture toughness suitable for use as, for example a beverage or food container, such as for example, a baby bottle or personal hydration bottle. The glass ceramic containers may have an average wall thickness in the range of 1 mm to 2.5 mm and a fracture toughness of 1 MPa*m{circumflex over (?)}1/2 or more.

Abstract: The present disclosure provides a transmission line defect identification method based on a saliency map and a semantic-embedded feature pyramid, including the following steps: step 1: cleaning and classifying a dataset; step 2: generating a super-resolution image for a small target of a transmission line by using an Electric Line-Enhanced Super-Resolution Generative Adversarial Network (EL-ESRGAN) model; step 3: performing image saliency detection on the dataset by constructing a U2-Net; step 4: performing data augmentation on the dataset by using GridMask and random cutout algorithms based on a saliency map, and generating a classified dataset; and step 5: performing image classification on a normal set and a defect set by using a ResNet34 classification algorithm and a deep semantic embedding (DSE)-based feature pyramid classification network.

Abstract: Provided in the present application is an ultrasonic probe, including: an ultrasonic transducer configured to send/receive an ultrasonic signal; a housing including a top plate and a side wall that collectively define a cavity with an opening located below the cavity, wherein a top portion of the ultrasonic transducer is configured to be accommodated in the cavity via the opening; and an elastic element accommodated in the cavity, the elastic element being connected to the top portion of the ultrasonic transducer and the top plate of the housing, and the elastic element being configured to provide an elastic force to the ultrasonic transducer to enable part of the ultrasonic transducer to retract and spring back within the cavity. Further provided in the present application are a scanning assembly including the ultrasonic probe and an ultrasonic imaging device including the scanning assembly.

Abstract: An MR-PET apparatus is provided. The MR-PET apparatus may include a supporting component, a PET detection device, an RF coil, and a signal shielding component. The PET detection device may be supported on the supporting component. The PET detection device may be configured to receive a plurality of photons. The RF coil may be configured to generate or receive a radio frequency (RF) signal. The signal shielding component may be placed between the PET detection device and the RF coil. The signal shielding component may be configured to shield the PET detection device from at least part of the RF signal.

Abstract: The present disclosure presents blockchain-based cyber security management systems and related methods. One such method comprises obtaining cyber intelligence input data from a cyber defender computing device, wherein the cyber defender computing device manages network security of a network, wherein the cyber intelligence input data identifies a cyber attacker or a victim of a cyber attack on the network; executing one or more Cyber Security Management (CSM) functions with the cyber intelligence input data received from the cyber defender computing device and cyber data stored in the blockchain ledger, wherein the cyber data stored in the blockchain ledger provides details on a cyber attack on a network that is managed by another cyber defender computing device; and outputting an alert to the cyber defender computing device with a potential cyber attacker or potential victim of the cyber attack on the network managed by the cyber defender computing device.

Abstract: An integrated circuit (IC) package may be fabricated having an interposer, one or more microfluidic channels through the interposer, a first IC chip attached to a first side of the interposer, and a second IC chip attached to a second side of the interposer, where the first side of the interposer includes first bond pads coupled to first bond pads of the first IC chip, and the second side of the interposer includes second bond pads coupled to first bond pads of the second IC chip. In an embodiment of the present description, a liquid cooled three-dimensional IC (3DIC) package may be formed with the IC package, where at least two IC devices may be stacked with a liquid cooled interposer. In a further embodiment, the liquid cooled 3DIC package may be electrically attached to an electronic board. Other embodiments are disclosed and claimed.

Abstract: A method with image processing includes: determining a feature map of an image; determining a spatial position weight of pixel points of the feature map; determining a corrected feature map by correcting the feature map based on the spatial position weight of the pixel points; and determining a key point based on the corrected feature map.