Abstract: Provided herein are methods and compositions relating to adenosine A2A receptor libraries having nucleic acids encoding for a scaffold comprising an adenosine A2A binding domain. adenosine A2A receptor libraries described herein encode for immunoglobulins such as antibodies.

Abstract: Provided herein are methods and compositions relating to variant nucleic acid libraries encoding for antibodies including single domain antibodies. Libraries generated using methods described herein have improved characteristics including improved binding affinity. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

Abstract: A rolling bearing combined fault diagnosis method based on a multi-domain feature construction is provided, including: collecting vibration signals of rolling bearings, extracting time-domain and frequency-domain features of fault-sensitive vibration signals of the rolling bearings, and obtaining an in-domain feature set; performing an improved empirical mode decomposition on the vibration signals of the rolling bearings to obtain time-frequency features; constructing a multi-domain fault sample set based on the in-domain feature set and the time-frequency features; performing a fault mechanism analysis on the multi-domain fault sample set to obtain modulation features under each single fault; carrying out a feature engineering on the time-domain and frequency-domain features, and screening out relevant features, redundant features and irrelevant features; performing an unsupervised hierarchical clustering on test set fault samples, and then inputting the test set fault samples into a KNN model for a classifi

Abstract: A selective catalytic reduction (SCR) system, comprising a box body, a mixer, a baffle and a carrier, the mixer, the baffle and the carrier being sequentially arranged inside the box body in an airflow direction inside the box body, the baffle being provided with a plurality of through holes, and the distribution density of the through holes and/or the hole area of the through holes being negatively correlated with a distribution uniformity index of NH3 at the baffle. The configuration of the distribution density and the hole area of the through holes can improve the mixing uniformity of ammonia gas, so that a reaction effect of a catalyst and a mixed gas in the carrier is enhanced. The settings of the distribution density and the hole area of the through holes can improve the mixing uniformity of an ammonia gas.

Abstract: Provided herein are methods and compositions relating to CD3 libraries having nucleic acids encoding for a scaffold comprising a CD3 domain. CD3 libraries described herein encode for immunoglobulins such as antibodies.

Abstract: The present disclosure provides a method for preparing a gallium nitride (GaN) single-crystal substrate with an edge metal mask technology. The method includes: preparing a metal mask ring on a composite epitaxial substrate, epitaxially growing a GaN single-crystal sacrificial layer in a confined manner, performing separation with interlayer decoupling of single-crystal graphene through an in-situ temperature gradient method to obtain a self-supporting GaN single-crystal sacrificial layer, epitaxially growing a GaN single-crystal thick film in a diameter expanded manner, and performing chemico-mechanical trimming on the GaN single-crystal thick film to obtain a stress-free self-supporting GaN single-crystal substrate. The metal mask ring is compatible with the GaN single-crystal preparation process (hydride vapor phase epitaxy (HVPE)), and efficiently catalyzes decomposition reaction of the nitrogen source.

Abstract: The present disclosure relates to a multi-cutting-edge diamond composite, including a columnar hard alloy substrate (102) and a diamond composite layer (101), the diamond composite layer (101) being disposed at a top end of the hard alloy substrate (102), wherein a circumferential edge of a top end of the diamond composite layer (101) is provided with at least two segments of different chamfers (103, 104) to form different cutting edges. By providing different chamfers on the circumferential edge of the top end of the diamond composite layer, multiple cutting edges are formed in the circumferential direction of an end face of the diamond composite, such that different edges of the same composite sheet have different attacking abilities and impact resistance abilities.

Abstract: A process for thin strip production integrates continuous casting and rolling, with steps including continuous casting, rough rolling, induction heating, finish rolling, laminar cooling, high-speed shearing, and coiling. A key feature is the in-line heating between casting and rough rolling, where wide surfaces, narrow surfaces, and corners of the casting blank are heated simultaneously. This process improves rough rolling efficiency, enhances uniformity and thickness stability of thin strips, reduces out-of-tolerance rates, and minimizes rolling-induced cracks.

Abstract: Various example embodiments for supporting communication network management may be configured to support communication network management based on various policies which may include one or more static rule-based policies (e.g., a rule-based resource management policy) and one or more machine learning (ML) based policies (e.g., an ML-based resource management policy). Various example embodiments for supporting communication network management may be configured to support communication network management based on evaluation and selection of policies to be applied for supporting communication network management. Various example embodiments for supporting communication network management may be configured to support communication network management based on regulation of network management actions generated based on selected policies before application of the network management actions to the communication network.

Abstract: Disclosed are a dynamic error measurement apparatus, system, and method for an electricity meter. The measurement apparatus includes a test signal generation unit configured to generate a voltage test signal and two-circuit current test signals, output the voltage test signal to a measurement unit, and output the two-circuit current test signals to the measurement unit and a current summation unit; the measurement unit configured to determine two-circuit electric energy values based on the voltage test signal and the two-circuit current test signals, and output the two-circuit electric energy values to a calculation control unit; the current summation unit configured to determine a combined current signal based on the two-circuit current test signals; and the calculation control unit configured to determine a total electric energy value based on the two-circuit electric energy values. The system includes a standard meter and a measurement apparatus.

Abstract: The antenna includes a plurality of radiating units arranged by column and including a plurality of radiating bodies and a reflecting plate which is configured to reflect a portion of electromagnetic waves radiated by the plurality of radiating bodies, such that the electromagnetic waves are radiated in a radiation orientation; and a dielectric component arranged in the radiation orientation of at least one radiating unit of the plurality of radiating units and including an undulating portion spaced apart from the at least one radiating unit by a distance, wherein a first undulating structure is provided on a lower surface of the undulating portion at least facing the at least one radiating unit in a transverse direction, the transverse direction being vertical to the column and parallel to the reflecting plate.

Abstract: The instant invention provides a deblocking double-layer chromatography and cassette for isolating nucleic acids from liquid biopsy samples such as urine with large sample volumes, small nucleic acid sizes, and low nucleic acid concentrations. Compared with the prior art of Ding et al. (U.S. Pat. No. 9,163,230) which proved the principle of double-layer chromatography comprising a positively charged DEAE membrane and a silica membrane, we further explored and optimized the membrane compositions and solution compositions for plasma and urine samples. More importantly, we set up a “deblocking” mechanism to overcome a “blocking” problem that the membrane is blocked by solid particles in the plasma and urine samples, thus greatly increasing its flowability. In addition, it omits a pre-filtering step, thus particularly suitable for its automation.

Abstract: In a method for predicting product assembly quality based on longitudinal unified learning, sample alignment is performed on a data sample of each participant to resolve problems of decentralization, nonuniformity, and scarcity of data; data partitioning is performed by a multi-player parallel structure on product assembly data by using a customized data partitioning policy, layer normalization is firstly performed by an encoder on partitioned data, and feature extraction is performed by a multi-thread attention layer to mine a correlation between each assembly production line inside the participant and assembly data of each device, so that a model feature extraction capability is enhanced; gradient security aggregation is performed on the local model of each participant by using a homomorphic encipherment method of secure multi-player computation, to obtain a global model, so that data of a plurality of sub-factories is merged to co-train a high-precision assembly quality prediction model.

Abstract: An optical satellite remote sensing transfer calibration method based on near-space aerostat, including: performing a temporal-spatial matching between first observation image data of a target region collected by a benchmark radiometric payload and second observation image data of the target region collected by a satellite-borne payload, to obtain a plurality of matchups of observation image data (S1); obtaining an average radiance of the benchmark radiometric payload from a plurality of first observation image data (S2); obtaining an average DN captured by the satellite payload in the target region from a plurality of second observation image data (S3); obtaining a matching radiance for an observation band of the benchmark radiometric payload corresponding to the satellite payload based on the average radiance of the benchmark radiometric payload (S4); and obtaining a calibration coefficient of the satellite payload based on the matching radiance and the average DN (S5).

Abstract: An intelligent modeling method of a Selective Catalytic Reduction (SCR) reaction process of diesel vehicle exhaust includes the following steps: S1: acquiring a time sequence data set of an SCR reaction process of diesel vehicle exhaust for modeling, where the time sequence data set includes an input variable sequence and an output variable sequence; S2: selecting a multi-layer type-II fuzzy neural network as an SCR reaction process model of diesel vehicle exhaust based on the input variable sequence and the output variable sequence obtained in Si. The intelligent modeling method of the SCR reaction process of diesel vehicle exhaust can effectively model dynamic characteristics of the SCR reaction process such as nonlinearity, time delay and uncertain interference, and improve the accuracy, robustness and generalization ability of the SCR reaction process model.

Abstract: Provided herein are methods and compositions relating to adenosine A2A receptor libraries having nucleic acids encoding for a scaffold comprising an adenosine A2A binding domain. adenosine A2A receptor libraries described herein encode for immunoglobulins such as antibodies.

Abstract: The present disclosure provides an isolated monoclonal antibody or an antigen-binding fragment thereof that binds specifically to leukocyte immunoglobulin-like receptor 4 (LILRB4). In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, modulates the activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, activates LILRB4. In certain embodiments, the antibody or antigen binding fragment, when bound to LILRB4, suppresses activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, specifically blocks binding of ApoE to LILRB4. In another aspect, there is provided a method of treating or ameliorating the effects of a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the antibody or an antigen-binding fragment thereof or an engineered cell as provided herein.

Abstract: Provided herein are methods and compositions relating to libraries of optimized antibodies having nucleic acids encoding for an antibody comprising modified sequences. Libraries described herein comprise nucleic acids encoding SARS-CoV-2 or ACE2 antibodies. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

Abstract: A signal processing system and method for a radiation detector based on a metal oxide semiconductor (MOS) transistor are disclosed. The signal processing system includes a power supply generation module, an analog signal processing module, and a digital signal acquiring-processing module. The power supply generation module provides a novel power supply method, and converts a positive high voltage power supply into a negative high voltage power supply to supply power to a last dynode of a photomultiplier tube (PMT). The analog signal processing module converts a negative current pulse signal into a voltage difference signal. The digital signal acquiring-processing module acquires a signal of the analog signal processing module, and converts the signal into a digital signal for identification.