Abstract: Disclosed is an implementation method for ultrasensitive Brink control for a delayed enzymatic reaction based on DNA strand displacement (DSD), relating to the field of feedback control technology based on DSD in biological systems. The method includes obtaining an enzymatic reaction process model with time delay; constructing a CRN-based Brink controller; obtaining a static mapping expression between an output of the Brink controller and an output of the system under a steady state condition; constructing a Brink controller by DSD reaction; obtaining a time delay representation, and applying it to DNA implementations of the enzymatic reaction process model; and combined with the Brink controller, controlling a delayed enzymatic reaction process model. The present invention is structurally free of subtraction, reduces the number of abstract chemical reactions required to implement, and greatly simplifies DNA implementation.

Abstract: An isolated monoclonal antibody capable of specifically binding to Trop2 is provided, together with a nucleic acid molecule encoding the antibody, as well as an expression vector, a host cell, and a method for expressing the antibody. An immunoconjugate, a bispecific molecule, a chimeric antigen receptor, an oncolytic virus, and a pharmaceutical composition containing the antibody, and a diagnostic or therapeutic method using the antibody are also provided.

Abstract: Methods, systems, and computer-readable storage media for providing a VM vector representative of resources that are to be consumed by the VM within the cloud computing environment, comparing the VM vector to each physical node vector in a set of physical node vectors to determine a distance, each physical node vector representative of resources available by a respective physical node, and selecting a physical node from a set of physical nodes based on a respective distance between the VM vector and a physical node vector representative of the physical node, and in response, automatically: deploying the VM to the physical node within the cloud computing environment at least partially by installing the VM on the physical node for execution thereon.

Abstract: Disclosed is a binding protein having at least two protein functional regions, the binding protein comprising a protein functional region A and a protein functional region B; the protein functional region A and the protein functional region B target different antigens or epitopes, the protein functional region A is a Fab or a scFv structure, the protein functional region B is a VH structure, and there are one or more of each of the protein functional region A and the protein functional region B. A multi-specific binding protein has a smaller molecular weight, fewer polypeptide chains, and a simpler structure. By means of different structure types, relative positions, binding valence and other parameters, the functional activities for different targets can be adjusted, and then different combinations of activities can be designed so as to meet the needs of different dose combinations of clinical combinations.

Abstract: A color wheel phase detection method and system, and a projection device. The phase detection system comprises a color wheel (1), a color wheel motor (2) that drives the color wheel (1) to rotate, and a control circuit (3); the color wheel motor (2) is a three-phase motor, and the control circuit (3) comprises a three-phase driving circuit (31) for driving the color wheel motor (2) to operate. The phase detection system further comprises a phase detection device (4) for detecting the three-phase driving circuit (31); when detecting a preset phase, the phase detection device (4) sends a pulse signal to the control circuit (3) to implement color wheel phase detection. Therefore, the effects of low costs, high accuracy, and high reliability are achieved.

Abstract: Provided is a binding protein, which comprises a protein functional region A and a protein functional region B, both of which target different antigens or different epitopes of antigens. The protein functional region A is Fab; the protein functional region B is VH; and the binding protein also comprises an Fc homodimer. There are two of both the protein functional region A and the protein functional region B. The binding protein has a left-right symmetrical structure. The binding protein consists of the protein functional region A, the protein functional region B and Fc in sequence from the N-terminus to the C-terminus, wherein the protein functional region A and the protein functional region B are connected by means of L1, and the protein functional region B is connected to the Fc by means of L2. The binding protein has a relatively small molecular mass, few polypeptide chains and a simpler structure. The protein has a versatile structure and may be applied to a variety of different target combinations.

Abstract: Disclosed is a use of 5?-methylthioadenosine in preparation of obesity-suppressing drugs or health care products. It is demonstrated from animal experiments that the 5?-methylthioadenosine has a significant suppression effect on obesity and has an excellent application prospect in preparation of obesity-suppressing drugs or health care products.

Abstract: Methods, systems, and computer-readable storage media for determining a set of estimated task execution times based on a set of task execution times, each estimated task execution time being calculated for a computing resource size that is different than a computing resource size of a corresponding task execution time in the set of task execution times, assigning a tag to each task in the set of tasks, each tag indicating a computing resource size that the respective tasks is to be executed by, providing the set of tasks and assigned tags for execution of the set of tasks in an iteration within the cloud system, and receiving actual task execution times from computing resources, each actual task execution time indicating an actual time required by a respective computing resource to execute a respective task.

Abstract: A color wheel phase detection method and system, and a projection device. The phase detection system comprises a color wheel (1), a color wheel motor (2) that drives the color wheel (1) to rotate, and a control circuit (3); the color wheel motor (2) is a three-phase motor, and the control circuit (3) comprises a three-phase driving circuit (31) for driving the color wheel motor (2) to operate. The phase detection system further comprises a phase detection device (4) for detecting the three-phase driving circuit (31); when detecting a preset phase, the phase detection device (4) sends a pulse signal to the control circuit (3) to implement color wheel phase detection. Therefore, the effects of low costs, high accuracy, and high reliability are achieved.

Abstract: An oxaazaquinazolin-7(8H)-ketone compound with a selective inhibition effect on KRAS gene mutation and pharmaceutically acceptable salts thereof, stereoisomers, solvent compounds or prodrugs (as shown in formula I or formula II, see the details of the definition to each group in the formulas in the specification), as well as the pharmaceutical composition containing the compound, and the application thereof in preparation of cancer medicine.

Abstract: A substituted heterocyclic amide compound having a selective inhibitory effect on RIPK1, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, and a pharmaceutical composition containing the compound, and the use of same in the preparation of a drug for treating a RIPK1-related diseases or conditions.

Abstract: A BLyS antibody, preparation method therefor and application thereof, the BLyS antibody comprising one or more of CDR1, CDR2 and CDR3 of a heavy chain variable region of the BLyS antibody, and/or one or more of CDR1, CDR2 and CDR3 of a light chain variable region of the BLyS antibody. An amino acid sequence of the antibody is shown in a sequence listing. The BLyS antibody has a high affinity, and may observably and effectively seal a BLyS protein at a protein level and a cell level, and prevent the BLyS protein from binding to a receptor. The BLyS antibody lacks a cross-reaction with homologous protein antigens such as human APRIL, and enjoys good biological activity. The BLyS antibody may inhibit the proliferation of human BLyS-induced mouse B cells and may therefore be used for preparing a drug for preventing or treating diseases associated with BLyS expression or dysfunction.

Abstract: The present invention discloses an N-sulfonyl benzamide derivative with a heterocyclic substituent, and a preparation method therefor and a pharmaceutical application thereof. More specifically, the invention discloses a compound represented by formula (II) or a pharmaceutically acceptable salt, stereoisomer, solvent compound, or prodrug thereof, and a preparation method therefor and an application thereof. Refer to the specification for definitions of each group in the formula.

Abstract: The present invention provides a class of 2,4-substituted phenylene-1,5-diamine derivatives, having an inhibiting effect on EGFR tyrosine kinases, and pharmaceutically acceptable salt, stereoisomer, solvate or prodrug of said derivatives. See the description for the definition of each group in the formula. In addition, the present invention also discloses pharmaceutical compositions, pharmaceutically acceptable compositions and applications thereof.

Abstract: A high-strength biological scaffold and preparation method thereof. The biological scaffold is comprised of a framework of boiled-off silk woven material, the form of the framework is determined by actual needs; the framework surface is coated with a layer of silk protein scaffold material, fibroin protein/gelatin biological scaffold material or fibroin protein/collagen biological scaffold material having a thickness of 100 micrometers to 5 centimeters. The high-strength biological scaffold material has high tear resistance strength and mechanical strength and good biocompatibility, has a porous structure suitable for tissue regeneration, and can be used for preparing anal fistula repair plugs.

Abstract: The present invention discloses an N-sulfonyl benzamide derivative with a heterocyclic substituent, and a preparation method therefor and a pharmaceutical application thereof. More specifically, the invention discloses a compound represented by formula (II) or a pharmaceutically acceptable salt, stereoisomer, solvent compound, or prodrug thereof, and a preparation method therefor and an application thereof.

Abstract: The present invention discloses a graphene/porous iron oxide nanorod composite and a method for preparing the same. The composite includes graphene and Fe2O3 nanoparticles loaded on the graphene. The Fe2O3 nanoparticles have a honeycomb porous structure. The synthesis method of the composite is simple and the raw materials are inexpensive.

Abstract: The present invention discloses a series of piperidine derivatives as orexin receptor antagonists and compositions thereof, and relates to the application thereof in preparing medications for the treatment of insomnia, chronic obstructive pulmonary disease, obstructive sleep apnea, hypersomnia, anxiety, obsessive-compulsive disorder, panic attack, nicotine addiction, or binge eating disorder.

Abstract: A vacuum electric kettle includes a vacuum layer disposed between a liner and an outer shell with a heating disc component disposed inside. A matched electrical connector is disposed between the heating disc component and the base that includes a disc body compounded with a heating body. A seal ring clamping platform is arranged at the edge of the disc body. At least two elastic supporting legs are integrated with the disc body and disposed below the clamping platform. A supporting leg locating ring and a seal ring limiting rib are disposed on the liner with a seal ring between the limiting rib and the clamping platform. The heating disc component and the kettle body are positioned in a matched mode through the elastic supporting legs and the supporting leg locating ring. No welding is required between the heating disc component and the kettle body of the vacuum electric kettle.