Abstract: Disclosed herein are compounds that inhibit cullin-RING E3 ubiquitin ligase 4, a method of inhibiting the catalytic activity of a Cullin-RING E3 Ubiquitin (Ub) Ligase (CRL) in a cell, compositions comprising the inhibitor compounds, a method of treating a tumor, and a method of treating a subject for cancer.

Abstract: The present invention provides an annular linear induction electromagnetic pump having axial guide vanes, wherein m axial guide vanes are uniformly arranged in a flow channel of the electromagnetic pump in a circumferential direction, a magnitude of m is equal to a number of external stators, and a length of each of the guide vanes is determined together by the number of the external stators, a central radius of the flow channel, a magnetic Reynolds number, and a wave number of a traveling magnetic field. The axial guide vanes can significantly mitigate the impact on the flow field stability caused by uneven circumferential disturbances of the magnetic field and flow field, thereby achieving a flow stabilization effect and greatly improving the flow stability in operation under off-design conditions.

Abstract: An annular linear induction electromagnetic pump having axial guide vanes is provided. m axial guide vanes are uniformly arranged in a flow channel of the electromagnetic pump in a circumferential direction, and a magnitude of m is equal to a number of external stators. A length of each of the guide vanes is precisely determined by a parameter P, and the value of the parameter P is calculated together by the number of the external stators, a central radius of the flow channel, a magnetic Reynolds number, a wave number of a traveling magnetic field and the mean fluid velocity. The axial guide vanes can significantly mitigate the impact on the flow field stability caused by uneven circumferential disturbances of the magnetic field and flow field, thereby achieving a flow stabilization effect with less hydraulic losses and greatly improving the flow stability in operation under off-design conditions.

Abstract: The present invention relates to a Salmonella bacteriophage, in particular to a Siphoviridae bacteriophage with a wide host spectrum and a strong lytic activity against Salmonella pullorum. The above-mentioned Salmonella pullorum bacteriophage is named SP4, and is deposited at the China General Microbiological Culture Collection Center, the deposit date is Jul. 27, 2017 and the deposit number is CGMCC No, 14332, The bacteriophage has a strong lysis effect on Salmonella, and the bacteriophage can also reduce the mortality rate of chicks infected with Salmonella pullorum, The preparation can be used alone or as a cocktail, and provides a safe, non-toxic and side-effect-free and residual effect-free bacteriophage product for the treatment of the infections caused by Salmonella of chicken origin, Salmonella of duck origin, Salmonella of mink origin, Salmonella of food origin and Salmonella of pig origin.

Abstract: The present disclosure provides methods for inhibiting intra and inter-cellular signaling pathways by modification of post-translation modification sites on select target RNA molecules. In certain example embodiments, the present disclosure provides methods for inhibiting intracellular phosphorylation of serine, threonine and tyrosine residues by editing the genetic codon of these amino acids by means of site-directed RNA editing or RNA molecules. Embodiments disclosed herein further provide methods of inhibiting pathological activation of cell signaling meditated by post-translational modifications, such as phosphorylation, which are involved in many diseases, including cancer, immunodeficiency, infectious diseases, inflammatory disorders and neurodegenerative disorders.

Abstract: A platform motor driving module includes a platform main controller, a complex driving unit, and a plurality of motor driving feedback units each including a motor driver and a driving signal feedback circuit. The driving signal feedback circuit is electrically connected to the motor driver and the platform main controller, and is configured to send a feedback signal of the motor driver to the platform main controller. The complex driving unit is individually connected to the motor drivers of the plurality of motor driving feedback units and is configured to respectively provide driving controlling signals to the motor drivers. The platform main controller is electrically connected to the complex driving unit to control the complex driving unit to generate the driving controlling signals, and electrically connected to the driving signal feedback circuits to receive the feedback signals. A platform system and a platform controlling system are also disclosed.

Abstract: A prepaid accounting system for a wireless local area network (WLAN) and a method thereof are provided. The system includes: an authentication control point, an authentication server, and a service control point. The authentication control point is used to control access of a subscriber to WLAN; the authentication server is used to perform authentication, authorization and accounting for the subscriber; and the service control point is used to store and update subscriber information. The method includes the steps of: upon the start of accounting, an authentication server requesting a service control point to check account balance of a subscriber; during the accounting, the authentication server periodically requesting the service control point to check the account balance of the subscriber; and upon the termination of accounting, the authentication server notifying the service control point of the termination of accounting and the service control point updating the balance.

Abstract: A symmetric dual-voltage charge pump and its control circuit generate bipolar output voltages. The charge pump converts a unipolar power source to a set of dual-voltage outputs of opposite polarity that are completely independent of each other. The charge pump includes two voltage-boosting transfer capacitors and two output capacitors. Two-phase operation generates an increased-magnitude output voltage of a negative polarity and another two phases of operation generate an increased output voltage of a positive polarity. The charge pump selectively charges one or both of the bipolar outputs with individual 2-phase charge cycles or with a sequence of charge cycles. When controlled by comparators with unequal reference voltages, the charge pump can force the bipolar outputs to unequal positive and negative voltages. Charge pumping is faster since only 2 phases are needed for charging either the positive or negative output.