Abstract: Provided are methods and compositions for treating hematological malignancies in patients carrying an IDH1 mutation using a combination of an inhibitor of mutant IDH1 enzyme, (S)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide, or a pharmaceutically acceptable salt thereof (COMPOUND 2) and a DNA demethylating agent.

Abstract: Methods and structures of a three-dimensional memory device are disclosed. In an example, the memory device includes a substrate, a first tier of conductor layers of a first length comprising a first plurality of conductor layers extending along a first direction over the substrate. The first direction is substantially parallel to a top surface of the substrate. In some embodiments, the memory device also includes at least one connection portion conductively connecting two or more conductor layers of the first tier, and a first metal contact via conductively shared by connected conductor layers of the first tier and connected to a first metal interconnect.

Abstract: A filtering device having UV light, that includes shell body having a water passage chamber, UV light is disposed in the water passage chamber. A glass tube set is disposed in the water passage chamber around outer periphery of the UV light. The glass tube set includes a first glass tube and a second gas tube both disposed around the outer periphery of the UV light. The lower end of the first glass tube is connected to and acts in cooperation with the lower end of the water passage chamber. The upper end of the first glass tube is separated from the upper end wall of the water passage chamber. The second glass tube is located around the outer periphery of the first glass tube. The lower end of the second glass tube is separated from the lower end wall of the water passage chamber.

Abstract: The invention discloses a low-frequency electrostatic ultrasonic atomization nozzle that relates to an electrostatic atomizer in the field of agricultural engineering. The low-frequency electrostatic ultrasonic atomization nozzle comprises a transducer back cover, piezoelectric ceramics, a transducer front cover, an ultrasonic horn and a fastening screw. Furthermore, the fastening screw is set through the transducer back cover, the piezoelectric ceramics and the center round hole of the transducer front cover in sequence; a liquid inlet channel is designed in the axial center of the ultrasonic horn; an air intake channel is designed in a position that deviates from the axial center; the top of the ultrasonic horn is machined as a concave spherical surface; and a suspended ball is arranged on the concave spherical surface.

Abstract: An ESD protection device for bidirectional diode string triggering SCR structure belongs to the field of electro-static discharge of an integrated circuit. A deep N well is arranged on a P substrate, and a first P well, a first N well, a second P well and a second N well are successively arranged from left to right on a surface region of the deep N well. In a second N well region, a mask preparing plate is used to insert the P wells at intervals. The circumference of each P well is isolated by the N well. Each P well is respectively provided with a pair of P+ implantation region and N+ implantation region. The metal wire is connected with the implantation region, and a positive electrode and a negative electrode are led out from the metal wire for forward conduction and reverse conduction.

Abstract: An in-water suction cleaner includes a portable housing for disposing at water of a pool or tank, a motorized unit supported in the portable housing for vacuuming a suction cavity of the portable housing to suck the water in the suction cavity out of the portable housing through a fluid outlet of the portable housing so as to create a suction at a fluid inlet of the portable housing, a manual scrubbing arrangement detachably coupled at the fluid inlet of the portable housing for scrubbing pool or tank surfaces and for sucking the water into the suction cavity at the same time, and a filtering element replaceably disposed in the suction cavity for filtering the water from the fluid inlet to the fluid outlet through the suction cavity so as to ensure the water after filtered being discharged back to the pool or tank via the fluid outlet.

Abstract: An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (HPLC), in particular, HPLC employing a reverse phase amide column with ELSD detection; the HPLC can be followed by tandem mass spectroscopy. The method can further comprise the step of performing preparative HPLC collection of at least one specific substance peak present in a preparation of dianhydrogalactitol.

Abstract: Disclosed are various embodiments for optimizing energy management. A quantity of renewable power that will be generated by renewable energy generation sources can be forecasted. The energy demand for a building or a cluster of buildings can be forecasted. A pricing model for buying energy from a grid can be determined. A quantity of energy to import from the grid or export to the grid can be scheduled based on the quantity of renewable energy forecasted and the state of charge or health of battery energy storage system, current and future operations of building HVAC, lighting and plug loads system, the forecasted energy demand for the building, and the pricing of the energy from the grid.

Abstract: Methods, systems, and computer programs are presented for cloud-offloaded position calculation with on-device acquisition. One method includes operations for collecting raw global positioning system (GPS) signals for a set of positions, and storing in memory the raw GPS signals. The method further includes processing the raw GPS signals in batch mode at the computing device to obtain acquisition data for the positions, where the processing includes identifying tasks for parallel processing by a graphics processing unit (GPU), performing, by the GPU, the tasks in parallel by assigning each of the tasks to a core processor within the GPU, and combining results from performing the tasks to obtain the acquisition data. Additionally, the method includes an operation for transmitting the acquisition data to a server for calculating locations for the set positions at the server, the server storing the locations and making the locations available for location-tracking applications.

Abstract: The present invention relates to a PI3K inhibitor, and a pharmaceutically acceptable salt, polycrystalline form, and application thereof. The invention specifically provides a polycrystalline form of 4-chloro-5-(6-(1-(methylsulfonyl)cyclopropyl)-2-morpholinopyrimidin-4-yl)pyridin-2-amine, a pharmaceutically acceptable salt thereof, or a polycrystalline form of the salt. The invention further discloses a pharmaceutical composition comprising the inhibitor and an application of the pharmaceutical composition.

Abstract: A reverse rotary sprinkler drilling pipe system with anti-sticking function and its application method. This system comprises the front and rear drilling pipes which are arranged in sequence, a water spraying device, a rotary device. The rear drilling pipe is connected with an external drilling rig. The front and rear drilling pipes are respectively arranged with through holes in an inner axial direction. The water spraying device comprises a first cylinder and a connecting body, and symmetrical multiple groups of water spraying holes are arranged on the inner sidewall of the first cylinder. A limit block is arranged in the upper part of the inner sidewall. The connecting body is disposed with water conveyance hole which is connected with the through hole and the inner part of the first cylinder.

Abstract: A water pump vibration damping device, that includes: a water pump, a main body, a soft pad, and a connection piece. The main body is disposed for the water pump to fix thereon, and is provided with a second connection hole. The soft pad is disposed between the water pump and the main body, and on the soft pad is disposed a first connection hole acting in cooperation with the second connection hole. The connection piece is used for penetrating it through the first connection hole and the second connection hole, to fix the soft pad and the main body together.

Abstract: A window air conditioner is provided. The window air conditioner includes an air conditioner body; and a sealing plate assembly disposed at at least one side of the air conditioner body and including a fixed sealing plate group and a sliding sealing plate group connected with the fixed sealing plate group in a sealing manner, in which the fixed sealing plate group is disposed on a side wall of the air conditioner body, and the sliding sealing plate group is disposed at a side of the fixed sealing plate group away from the air conditioner body slidably in a direction approaching to or moving away from the air conditioner body.

Abstract: A window air conditioner is provided. The window air conditioner includes an air conditioner body configured to be mounted to a mounting window; and a heat-insulation sealing assembly having at least two layers and provided between the air conditioner body and the mounting window to insulate an inside of the mounting window from an outside of the mounting window.

Abstract: [Problem] The main purpose is to provide a novel carbon-containing solid acid which has an excellent catalytic activity and of which the catalytic activity cannot be deteriorated easily even when used repeatedly. [Solution] A carbon-containing solid acid which comprises a carbonaceous material having a sulfonate group, wherein the carbonaceous material has a graphene structure in at least a part thereof and contains boron.

Abstract: The present disclosure relates to the field of ceramics, and discloses a metal-based aluminum nitride composite material. The composite material includes an aluminum nitride ceramic skeleton and a metal filling at least part of pores of the aluminum nitride ceramic skeleton. The aluminum nitride ceramic skeleton contains aluminum nitride and CuAlO2, and the aluminum nitride ceramic skeleton has a porosity of 20 to 40 percent. The present disclosure further discloses a method for preparing the metal-based aluminum nitride composite material and the metal-based aluminum nitride composite material obtained by the method. A CuAlO2 substance is formed in the aluminum nitride ceramic skeleton obtained in the present disclosure.

Abstract: Embodiments of the invention provide a method, system, and computer readable medium for classifying network traffic based on application signatures generated during a training phase. The application signatures are generated based on tokens extracted from a training set that is generated by a particular application during the training phase. Accordingly, a new token extracted in real-time from current network data is compared to the application signatures to determine if the current network data is generated by the particular application.

Abstract: The present invention relates to a PI3K inhibitor, and a pharmaceutically acceptable salt, polycrystalline form, and application thereof. The invention specifically provides a polycrystalline form of 4-chloro-5-(6-(1-(methylsulfonyl)cyclopropyl)-2-morpholinopyrimidin-4-yl)pyridin-2-amine, a pharmaceutically acceptable salt thereof, or a polycrystalline form of the salt. The invention further discloses a pharmaceutical composition comprising the inhibitor and an application of the pharmaceutical composition.

Abstract: A filter cartridge having a double water-stop function, that comprises: a filter cartridge main body, a rotation body, and a water channel main body. The filter cartridge main body includes: an outer shell body, a filter cartridge, a filter cartridge cover, a first water outlet, a second water outlet, a first compression spring, a second compression spring, a first tight seal ring, a second tight seal ring, a first water input port, a second water input port, a first water outlet channel, and a second water outlet channel. The rotation body includes: a first water channel, a second water channel, a third water channel. The water channel main body includes: a first water input hole, a first water output hole, and a second water output hole.