Abstract: The invention relates to uricase-drug conjugates comprising a uricase with a linker-drug attached to either the protein core or other moiety attached to the protein core. The pegylated uricase-drug conjugates mitigate the formation of anti-drug antibodies to improve the therapeutic efficacy of enzymes such as uricase. The uricase-drug conjugate may be administered subcutaneously or intravenously.

Abstract: Various embodiments include a camera system that includes an actuator arrangement that enables autofocus (AF) and/or optical image stabilization (OIS) motion. In various embodiments, the actuator arrangement may include one or more shape memory alloy (SMA) actuators. For example, the camera system may include an AF SMA actuator comprising a plurality of SMA wires configured to move a lens group of the camera system, relative to an image sensor of the camera system, in directions parallel to an optical axis. In some embodiments, the camera system may include an OIS actuator configured to tilt the lens group, together with the image sensor, about multiple axes orthogonal to the optical axis.

Abstract: The present invention relates to the synthesis of 3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a salt thereof, and related synthetic intermediate compounds.

Abstract: A head protection device for wrapping a shoulder belt and a length adjustment device of a carrier, the shoulder belt connected to a backrest and a seat of the carrier, and the shoulder belt wound around the length adjustment device, the length adjustment device slideable relative to the shoulder belt along a length extension direction of the shoulder belt. The head protection device includes a protection sheet, including a first part located between the length adjustment device and the backrest, and a limiting structure, arranged on the first part, wherein, the shoulder belt passes through the protection sheet twice in opposite directions at at least one position on the first part through the limiting structure, and the protection sheet is slidable relative to the shoulder belt along a length extension direction of the shoulder belt, the length adjustment device synchronously slides with the protection sheet on the shoulder belt.

Abstract: The various embodiments of the present application provide a switch, which includes: a first detection circuit, a control circuit, and a power extraction circuit; wherein, the first detection circuit is configured to detect an operating mode of the switch; the operating mode includes a first mode and a second mode; the control circuit is connected to the first detection circuit and the power extraction circuit, and is configured to control the power extraction circuit to draw power according to the corresponding power extraction mode based on the operating mode of the switch. The embodiments of the present application solve the problem that exists in the related art, where the single with neutral universal switch is not yet capable of providing a rich set of functional circuits, leading to a low usage rate.

Abstract: A method and a system for optimizing operating swing of a vertical shaft suspended hydrogenerator unit, and the method includes: measure turning swing and operating parameters of the unit during turning, calculate direction of relative displacement between the rotating center of each bearing for the unit and a center line of a main shaft, and calculate and adjust offset distance of an installation center for a guide bearing to a certain direction by the temperature of a bearing bush; then carry out a temperature rise test of the unit, optimize the operating swing of the hydrogenerator unit while the bush temperature is less than the design requirement, and select optimal bush gap to achieve optimal operating swing and ensure that the bush temperature, the cooling oil level, the cooling oil temperature and the operating swing reach the most scientific and reasonable balanced state.

Abstract: A camera includes a lens carrier to which lens(es), defining an optical axis, are mounted. The lens carrier and the lens(es) are movable along the optical axis. The camera includes an autofocus (AF) damping structure for dampening motion of the lens carrier and the lens(es) in a direction along the optical axis. The camera includes a flexure platform having a dynamic platform to which an image sensor and a substrate are connected for movement together with the dynamic platform, a static platform connected to a static portion of the camera, and multiple flexure arms that mechanically connect the dynamic platform to the static platform. The camera includes electronic component(s) and a volume of space vertically aligned with the AF damping structure and extending from the AF damping structure to the substrate. The volume of space does not include a mounting location of the electronic component(s).

Abstract: In one embodiment, a method for achieving zero packet loss in wireless roaming is implemented by a processor of a wireless client device in a system. The wireless client device establishes a first data plane in association with a first radio connected to a first access point and a second data plane in association with a second radio. The first data plane is different from and operates concurrently with the second data plane. The wireless client device determines a second access point by scanning a plurality of operating channels using the second radio. The wireless client device synchronizes the second data plane with a network controller to connect the second radio with the second data plane to the second access point. The wireless client device switches traffic of the first data plane connected to the first access point to the second data plane connected to the second access point.

Abstract: A battery pack and an electrical consumer are provided. The battery pack includes multiple battery cells, a box, and a handle. The box defines a first accommodation cavity and a second accommodation cavity, the second accommodation cavity is defined at a side of the first accommodation cavity, the multiple battery cells are accommodated in the first accommodation cavity, at least one reinforcing portion is disposed in the second accommodation cavity, and the at least one reinforcing portion protrudes from a top of the second accommodation cavity towards a bottom of the second accommodation cavity. The handle includes a handle body and a connecting portion. The connecting portion is connected with the handle body, the connecting portion defines at least one top-open groove at a top of the connecting portion, and the connecting portion is disposed in the second accommodation cavity.

Abstract: The present application relates to a warming-up control method for a fuel cell system in a starting process and a fuel cell system, applied to the technical field of fuel cells. The method includes: starting the fuel cell system, turning on a small-cycle cooling circuit, and pull-loading an output power to a first power; in response to an inlet temperature of a stack reaching a first temperature, rotating a three-way valve at a first rotating rate; calculating a variance of a cell voltage value; in response to the variance being smaller than a third threshold and reducing the variance to be within the first threshold, returning to the rotating the three-way valve at the first rotating rate until all turn-on of a large-cycle cooling circuit and all turn-off of the small-cycle cooling circuit; pull-loading the output power to a rated power.

Abstract: In one embodiment, a method for achieving zero packet loss in wireless roaming is implemented by a processor of a wireless client device in a system. The wireless client device establishes a first data plane in association with a first radio connected to a first access point and a second data plane in association with a second radio. The first data plane is different from and operates concurrently with the second data plane. The wireless client device determines a second access point by scanning a plurality of operating channels using the second radio. The wireless client device synchronizes the second data plane with a network controller to connect the second radio with the second data plane to the second access point. The wireless client device switches traffic of the first data plane connected to the first access point to the second data plane connected to the second access point.

Abstract: An ultrasonic surgical instrument includes a waveguide for transmitting ultrasonic energy, the distal end of the waveguide connected to a blade; a jaw member pivotable with respect to the blade; an inner tube sleeved on the waveguide; and an outer tube sleeved on the inner tube. The jaw member is pivotally connected to the distal end of the outer tube, the distal end of the inner tube acting on the jaw member, and the inner tube sliding with respect to the outer tube and driving the jaw member to pivot with respect to the blade. A first abutting portion provided on the distal ends of the inner tube and the outer tube forms a support between the inner and outer tube, so as to avoid a radial clearance change between the inner tube and the outer tubes without affecting the relative sliding movement of the inner and outer tubes.

Abstract: A camera includes a lens carrier to which lens(es), defining an optical axis, are mounted. The lens carrier and the lens(es) are movable along the optical axis. The camera includes an autofocus (AF) damping structure for dampening motion of the lens carrier and the lens(es) in a direction along the optical axis. The camera includes a flexure platform having a dynamic platform to which an image sensor and a substrate are connected for movement together with the dynamic platform, a static platform connected to a static portion of the camera, and multiple flexure arms that mechanically connect the dynamic platform to the static platform. The camera includes electronic component(s) and a volume of space vertically aligned with the AF damping structure and extending from the AF damping structure to the substrate. The volume of space does not include a mounting location of the electronic component(s).

Abstract: The present invention provides for the use of recombinant Endo-S2 mutants (named Endo-S2 glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent.

Abstract: A microscopy imaging system comprises a fluorescence lifetime imaging microscopy (FLIM) system comprising a pulsed light source configured to direct a plurality of excitation light pulses onto a sample, a photo detector configured to detect emitted fluorescent photons created by the plurality of excitation pulses interacting with the sample, and a FLIM data acquisition system configured to measure the time interval between the excitation light pulses and the detected emitted fluorescent photons, a scanning light microscopy (SLM) system comprising a SLM data acquisition system, a fast scanning mirror and a slow scanning mirror, wherein the mirrors are configured to scan the light pulses across the sample; and a data processing system communicatively connected to the FLIM and SLM systems. Microscopy imaging methods are also disclosed.

Abstract: A method of fractionating lignocellulosic biomass includes fractionating lignocellulos biomass in an aqueous phenol-4-sulfonic acid (PSA). The process may provide complete or nearly complete fractionation under mild conditions.

Abstract: Various embodiments include a damper arrangement that may be used to dampen motions of a dynamic component. In some embodiments, the damper arrangement may be used in a camera module that includes a stationary component and a dynamic component. For instance, the dynamic component may hold a lens such that the lens moves together with the dynamic component. In various examples, the damper arrangement may include an interface member that extends from the stationary component or the dynamic component to at least partially into a viscoelastic material within a pocket configured in the stationary component, the dynamic component, or both. The interface member may be configured to traverse within the viscoelastic material to dampen motion of the dynamic component, for example, during operation of a lens actuator to move the dynamic component along an optical axis of the lens.

Abstract: The present application relates to a startup control method and apparatus for a fuel cell system, an electronic device, and a medium, applied to the technical field of fuel cells. The method includes: setting a loading current as a first current value, in response to a monolithic voltage value of a stack being smaller than the first voltage value, decreasing the loading current; in response to the decreased loading current being larger than a second current value and the monolithic voltage value being larger than or equal to the first voltage value, running the fuel cell system for a period of time under the loading current, and then returning for setting the loading current as the first current value.

Abstract: The present application relates to a warming-up control method for a fuel cell system in a starting process and a fuel cell system, applied to the technical field of fuel cells. The method includes: starting the fuel cell system, turning on a small-cycle cooling circuit, and pull-loading an output power to a first power; in response to an inlet temperature of a stack reaching a first temperature, rotating a three-way valve at a first rotating rate; calculating a variance of a cell voltage value; in response to the variance being smaller than a third threshold and reducing the variance to be within the first threshold, returning to the rotating the three-way valve at the first rotating rate until all turn-on of a large-cycle cooling circuit and all turn-off of the small-cycle cooling circuit; pull-loading the output power to a rated power.