Abstract: A modified adeno-associated virus (AAV) capsid protein and use thereof are disclosed. The capsid protein contains a substitution(s) of approximately 5-14 amino acids with respect to a parent AAV capsid protein. The AAV containing the modified capsid protein has increased infectiousness with respect to a target tissue or target cell (e.g. retinal cell) in comparison with an AAV containing an unmodified parent AAV capsid protein.

Abstract: The present application relates to an electrode sheet, a battery cell and a battery. The electrode sheet includes a current collector and a protective layer. The current collector includes a coated region provided with an active material layer and an uncoated region without being provided with the active material layer. The protective layer is provided on at least a part of a surface of the uncoated region, and has a porosity of 0% to 95%. For the electrode sheet according to the present application, by providing the current collector with the protective layer, the contact resistance may be increased when the electrode sheet is short-circuited, and the discharge power and the thermal runaway probability of the battery cell may be reduced when the battery cell is internally short-circuited, thereby improving the safety performance of the battery cell.

Abstract: Embodiments of the present disclosure relate to a music generation method, apparatus, system and storage medium. In at least some embodiments of the present disclosure, by displaying a music generation interface including a text input box, a music generation control and a music configuration item in response to an operation by a user triggering the music generation control, so that the user can input a custom text in the text input box and configure a music melody through the music configuration item, and then in response to an operation by the user triggering the music generation control, it is possible to generate a voice based on the custom text input by the user, and generate a music including the voice corresponding to the custom text based on the generated voice and the user configured music melody.

Abstract: An electrode sheet has a first end and a second end opposite each other, and includes a current collector, active materials disposed on a first coated zone and a second coated zone, and a plurality of electrode tabs. The current collector includes a side edge, opposing first and second surfaces. The first surface includes a first coated zone and a first uncoated zone, and the second surface includes a second coated zone. At the first end, the first coated zone and the second coated zone are flush. At the second end, the first coated zone is misaligned with the second coated zone. The sum of the length of the first coated zone and the length of the first uncoated zone is equal to the length of the second coated zone. Each electrode tab is coupled to the current collector and protrudes beyond the side edge.

Abstract: The present invention relates to the field of ophthalmic therapies, specifically to ocular injection assemblies, injection devices and methods of use. The ocular injection assembly comprises a sleeve and a needle. The needle is capable of being set within the sleeve. A clamping port is provided at the end of the sleeve. A tip portion of the needle can pass through the clamping port during use. When using the ocular injection assembly, the clamping port of the sleeve is contacted with and pressed against the ocular tissue at the injection site to cause the ocular tissue at the injection site to protrude into the sleeve, which can significantly improve the success rate of the injection.

Abstract: An electrode sheet has a first end and a second end opposite each other, and includes a current collector, active materials disposed on a first coated zone and a second coated zone, and a plurality of electrode tabs. The current collector includes a side edge, opposing first and second surfaces. The first surface includes a first coated zone and a first uncoated zone, and the second surface includes a second coated zone. At the first end, the first coated zone and the second coated zone are flush. At the second end, the first coated zone is misaligned with the second coated zone. The sum of the length of the first coated zone and the length of the first uncoated zone is equal to the length of the second coated zone. Each electrode tab is coupled to the current collector and protrudes beyond the side edge.

Abstract: An electrochemical apparatus includes a negative electrode, and the negative electrode includes a porous carbon material layer and a negative electrode active material layer, where the porous carbon material layer includes porous carbon material particles, each porous carbon material particle includes at least two types of pores among micropores, mesopores, and macropores, and the at least two types of pores communicate with each other, where a pore size of each micropore<2 nm, 2 nm?a pore size of each mesopore?50 nm, and 50 nm<a pore size of each macropore?500 nm.

Abstract: An electrochemical device, including a cell and a shell enclosing the cell; the cell includes a jelly roll including a first electrode and a second electrode spaced from each other, a separator is disposed between the first electrode and the second electrode, the first electrode and the second electrode are wound to form the cell; the first electrode includes a first current collector, the first current collector includes a first surface and a second surface disposed oppositely; the first surface faces the shell, and includes a coated region coated with a first active material and an uncoated region; the uncoated region includes a first uncoated region disposed at an end of the jelly roll, and the first uncoated region includes alternating bent portions and straight portions; and the bent portions are provided with an insulating layer.

Abstract: An electrochemical device, including a cell and a shell enclosing the cell; the cell includes a jelly roll including a first electrode and a second electrode spaced from each other, a separator is disposed between the first electrode and the second electrode, the first electrode and the second electrode are wound to form the cell; the first electrode includes a first current collector, the first current collector includes a first surface and a second surface disposed oppositely; the first surface faces the shell, and includes a coated region coated with a first active material and an uncoated region; the uncoated region includes a first uncoated region disposed at an end of the jelly roll, and the first uncoated region includes alternating bent portions and straight portions; and the bent portions are provided with an insulating layer.

Abstract: The disclosure relates, in some aspects, to compositions and methods for treating corneal disease (e.g., corneal neovascularization. In some embodiments, the disclosure relates to rAAV-mediated delivery of an cornea-associated transgene to a subject. In some embodiments, the rAAV transduces the corneal tissue of a subject.

Abstract: The application refers to a pharmaceutical composition, containing elemene, a protein carrier, and oil for injection, having improved safety and stability.

Abstract: A cell, formed by winding or stacking a first electrode and a second electrode which are arranged at an interval, and a separator is disposed between the first electrode and the second electrode. The first electrode includes a first current collector, and the first current collector includes a coated region coated with a first active material and an uncoated region without the first active material; the uncoated region is at least partially provided with an insulating layer. The adhesion between the insulating layer and the first current collector is not less than about 0.5 N/m.

Abstract: The present application relates to an electrochemical device. Specifically, the present application provides a cell, wherein the cell is formed by winding or stacking a first electrode and a second electrode which are arranged at an interval, and a separator is disposed between the first electrode and the second electrode. Wherein the first electrode includes a first current collector, and the first current collector includes a coated region coated with a first active material and an uncoated region without the first active material; the uncoated region is at least partially provided with an insulating layer. The adhesion between the insulating layer and the first current collector is not less than about 0.5 N/m. The electrochemical device provided by the present application has improved safety performance.

Abstract: A method for enhancing battery cycle performance. The method is applied in a battery and includes: charging, at a first stage, the battery at a first-stage current until reaching a first-stage voltage; and charging, at a second stage, the battery at a second-stage current until reaching a second-stage voltage. The second-stage voltage is greater than the first-stage voltage, and the second-stage current is less than the first-stage current. The battery includes an electrolytic solution containing an organic solvent. The organic solvent includes a chain carboxylate compound. A weight percent of the chain carboxylate compound in the organic solvent is 10% to 70%. This application further provides an electronic device. The method can enhance high-temperature cycle and storage performance of the battery.

Abstract: An electrochemical device, including a cell and a shell enclosing the cell; the cell includes a jelly roll including a first electrode and a second electrode spaced from each other, a separator is disposed between the first electrode and the second electrode, the first electrode and the second electrode are wound to form the cell; the first electrode includes a first current collector, the first current collector includes a first surface and a second surface disposed oppositely; the first surface faces the shell, and includes a coated region coated with a first active material and an uncoated region; the uncoated region includes a first uncoated region disposed at an end of the jelly roll, and the first uncoated region includes alternating bent portions and straight portions; and the bent portions are provided with an insulating layer.

Abstract: The present application relates to an electrochemical device. Specifically, the present application provides an electrochemical device, including a cell and a shell enclosing the cell; the cell includes a jelly roll including a first electrode and a second electrode spaced from each other, a separator is disposed between the first electrode and the second electrode, the first electrode and the second electrode are wound to form the cell; the first electrode includes a first current collector, the first current collector includes a first surface and a second surface disposed oppositely; the first surface faces the shell, and includes a coated region coated with a first active material and an uncoated region; the uncoated region includes a first uncoated region disposed at an end of the jelly roll, and the first uncoated region includes alternating bent portions and straight portions; and the bent portions are provided with an insulating layer.

Abstract: Provided are electrochemical cells and methods of manufacturing these cells. An electrochemical cell comprises a positive electrode and an electrolyte layer, printed over the positive electrode. In some examples, each of the positive electrode, electrolyte layer, and negative electrode comprises an ionic liquid enabling ionic transfer. The negative electrode comprises a negative active material layer (e.g., comprising zinc), printed over and directly interfacing the electrolyte layer. The negative electrode also comprises a negative current collector (e.g., copper foil) and a conductive pressure sensitive adhesive layer. The conductive pressure sensitive adhesive layer is disposed between and adhered to, directly interfaces, and provides electronic conductivity between the negative active material layer and the negative current collector. In some examples, the conductive pressure sensitive adhesive layer comprises carbon and/or metal particles (e.g., nickel, copper, indium, and/or silver).

Abstract: The disclosure relates, in some aspects, to compositions and methods for treating corneal disease (e.g., corneal neovascularization. In some embodiments, the disclosure relates to rAAV-mediated delivery of an cornea-associated transgene to a subject. In some embodiments, the rAAV transduces the corneal tissue of a subject.

Abstract: Provided are electrochemical cells and methods of manufacturing these cells. An electrochemical cell comprises a positive electrode and an electrolyte layer, printed over the positive electrode. In some examples, each of the positive electrode, electrolyte layer, and negative electrode comprises an ionic liquid enabling ionic transfer. The negative electrode comprises a negative active material layer (e.g., comprising zinc), printed over and directly interfacing the electrolyte layer. The negative electrode also comprises a negative current collector (e.g., copper foil) and a conductive pressure sensitive adhesive layer. The conductive pressure sensitive adhesive layer is disposed between and adhered to, directly interfaces, and provides electronic conductivity between the negative active material layer and the negative current collector. In some examples, the conductive pressure sensitive adhesive layer comprises carbon and/or metal particles (e.g., nickel, copper, indium, and/or silver).

Abstract: The disclosure relates, in some aspects, to compositions and methods for treating corneal disease (e.g., corneal neovascularization. In some embodiments, the disclosure relates to rAAV-mediated delivery of an cornea-associated transgene to a subject. In some embodiments, the rAAV transduces the corneal tissue of a subject.