Abstract: Systems and methods for analyzing samples are provided. In some embodiments, a mass spectrometer may include a source configured to output one or more ions, a plurality of chambers having different pressures, a detector configured to detect the one or more ions, and a particle guide. The plurality of chambers may include at least a first chamber having a first pressure that is less than atmospheric pressure and a second chamber having a second pressure that is less than the first pressure. In some embodiments, the particle guide may include a conduit through which the one or more ions may travel an entire length of the particle guide. The conduit may be disposed within at least the first chamber and the second chamber, and vents may be disposed to define passages between the chambers and the conduit.

Abstract: Methods of sequencing a protein using a novel digestion-on-emitter technology are provided.

Abstract: Systems and methods for analyzing samples are provided. In some embodiments, a mass spectrometer may include a source configured to output one or more ions, a plurality of chambers having different pressures, a detector configured to detect the one or more ions, and a particle guide. The plurality of chambers may include at least a first chamber having a first pressure that is less than atmospheric pressure and a second chamber having a second pressure that is less than the first pressure. In some embodiments, the particle guide may include a conduit through which the one or more ions may travel an entire length of the particle guide. The conduit may be disposed within at least the first chamber and the second chamber, and vents may be disposed to define passages between the chambers and the conduit.

Abstract: Systems and methods for analyzing samples are provided. In some embodiments, a mass spectrometer may include a source configured to output a plurality of particles, a tube having a central axis, and a skimmer. In some embodiments, the skimmer may include an aperture arranged to receive the one or more charged particles deflected by a deflector and a contact surface comprising an intersection point that intersects the central axis of the tube. The intersection point may be spaced from the aperture by a distance of at least 5 mm.

Abstract: Methods of sequencing a protein using a novel digestion-on-emitter technology are provided.

Abstract: Methods of sequencing a protein using a novel digestion-on-emitter technology are provided.

Abstract: A holder for capillary columns (130) is realized by a mechanical holding device, also called a lead holder, which can be a mechanical pencil. The user holds the holding device in one hand and presses on an actuator (100) at the top of the holder, springably urging a plurality of jaws (115) to open. The user then slidably inserts the capillary column into the holder a desired distance and releases the actuator, causing the jaws to close around the capillary column and hold it in position within the holder. Next, a cap (140, 140?) is optionally slidably urged over the end of the holder in order to protect the exposed tip (135) of the capillary column. Removal of the capillary column is accomplished by reversing the above procedure to release the capillary column, allowing the column to be withdrawn.