Abstract: The present disclosure belongs to the technical field of medicine, and relates to a use of a GABAA receptor as a target in the preparation or screening of a drug for reducing blood lipid, treating obesity, and/or improving metabolism. The present disclosure provides a use of a GABAA receptor as a target in the preparation or screening of a drug with one or more functions selected from the group consisting of functions (1) to (4): (1) reducing blood lipid; (2) treating obesity; (3) improving metabolic syndrome; and (4) inhibiting small intestinal lipid absorption. The GABAA receptor is closely related to a lipid absorption ability of a small intestine, and the use of the present disclosure provides a new drug target and a new therapeutic means for treating obesity, reducing blood lipid, and improving metabolism.