Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.

Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), intermediates of formula (IV), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.

Abstract: An optimization method for a digital integrated circuit is provided. Under the precondition of satisfying certain timing constraints, circuit-level, path-level and gate cell-level features of a circuit are extracted to construct a leakage power optimization model, and optimization data from commercial circuit optimization tools is used to train the model to predict voltage threshold types of gate cells after circuit optimization, such that the circuit can be optimized by adjusting voltage thresholds of gate cells in a post-routing gate-level netlist, thus realizing the optimization objective of reducing leakage power.

Abstract: An optimization method for a digital integrated circuit is provided. Under the precondition of satisfying certain timing constraints, circuit-level, path-level and gate cell-level features of a circuit are extracted to construct a leakage power optimization model, and optimization data from commercial circuit optimization tools is used to train the model to predict voltage threshold types of gate cells after circuit optimization, such that the circuit can be optimized by adjusting voltage thresholds of gate cells in a post-routing gate-level netlist, thus realizing the optimization objective of reducing leakage power.

Abstract: A method of ctDNA library construction and sequencing data analysis for simultaneously detecting multiple common mutations in liver cancer. The library construction method and sequencing data analysis process have the following advantages: 1. Simultaneous detection of multiple mutation forms in liver cancer without capturing; 2. Suitable for efficient capture of ultra-small target regions; 3. The library may support 10-20 tests; 4. Ligate the DNA barcode to the starting ctDNA molecule during the library construction process, and cooperate with the biological information analysis process to achieve high specific detection of low-frequency mutations in ctDNA; 5. The library is usable for PCR hot spots detection and sequencing by a capture method at the same time, the added DNA barcode may effectively filter out false positive mutations and achieve high-specificity sequencing based on duplex.

Abstract: A method and system for detecting dirt on an electrode of an electromagnetic flowmeter are provided. The method includes: under three different conditions acquiring resistance values between the electrode and ground to form a first dataset, second datasets, and a sample set to be tested; extracting a positive definite feature matrix corresponding to each sample batch and calculating a Riemann center thereof; calculating a similarity index between the sample feature matrix and each of the first feature matrices and the second feature matrices; extracting l feature matrices with a largest similarity index, and calculating a local Riemann center thereof; and calculating proximity between the local Riemann center and each of the second Riemann centers, and determining that a Riemann center with the greatest proximity corresponds to dirt on the electrode corresponding to the sample set to be tested. The method can achieve a online rapid detection of dirt on the electrode.

Abstract: The present invention discloses a method for detecting the mutation and methylation of tumor-specific genes in ctDNA, and this method can simultaneously detect the mutation (including point mutation, insertion-deletion mutation, HBV integration and other mutation forms) and/or methylation of tumor-specific genes in ctDNA in one sample. Not only the sample size requirement is low, but the MC library prepared by this method can support 10-20 subsequent detections. The results of each test can represent the mutation status of all the original ctDNA specimens and the methylation modification status of the region covered by the restriction sites, without reducing the sensitivity and specificity. The present invention has important clinical significance for early tumor screening, disease tracking, efficacy evaluation, prognosis prediction and the like, and has great application value.

Abstract: Disclosed is a near-threshold cell circuit delay model, where obtaining parameters includes obtaining process parameters, current parameters and delay parameters with slow input transition; judging a cell circuit type includes judging whether a cell circuit is an inverter, a stacked structure cell or a parallel structure cell, calculating currents and a current integral according to the cell circuit type, calculating a mean value, a variance and a skewness of a logarithm of the current sum, and calculating a mean value and a variance of an equivalent threshold voltage; judging a delay type includes calculating an overshoot time and a delay according to the cell circuit type, comparing the magnitude relationship among an input transition time, the overshoot time and the delay, and judging whether the delay type is ultra-fast input, fast input or slow input; establishing a cell circuit nominal delay model is establishing the cell circuit nominal delay model according to the cell circuit type and the delay type,

Abstract: The present invention provides a kit for early screening of hepatocellular carcinoma, comprising a gene marker detection reagent and a protein marker detection reagent. The invention also provides a preparation method and application of the kit. The kit comprising specific gene markers and protein markers of the present invention has been demonstrated to be effective in achieving early screening of HCC in community populations, particularly in prospective studies.

Abstract: A method of ctDNA library construction and sequencing data analysis for simultaneously detecting multiple common mutations in liver cancer. The library construction method and sequencing data analysis process have the following advantages: 1. Simultaneous detection of multiple mutation forms in liver cancer without capturing; 2. Suitable for efficient capture of ultra-small target regions; 3. The library may support 10-20 tests; 4. Ligate the DNA barcode to the starting ctDNA molecule during the library construction process, and cooperate with the biological information analysis process to achieve high specific detection of low-frequency mutations in ctDNA; 5. The library is usable for PCR hot spots detection and sequencing by a capture method at the same time, the added DNA barcode may effectively filter out false positive mutations and achieve high-specificity sequencing based on duplex.

Abstract: A loudspeaker module, relating to the technical field of electroacoustic products. The loudspeaker module comprises a housing. A loudspeaker unit is accommodated in the housing. An electrical connection member which is a metal sheet is fixed on the housing. An inner bonding pad is disposed at one end of the electrical connection member, and an outer bonding pad is disposed at the other end of the electrical connection member. The inner bonding pad is located in the housing and is electrically connected to the loudspeaker unit. The outer bonding pad is exposed outside the housing and is electrically connected to a terminal circuit. The loudspeaker module of the present invention solves the technical problems in the prior art such as poor tone quality, low reliability, and a complicated assembling process of a loudspeaker module.

Abstract: A loudspeaker module, relating to the technical field of electroacoustic products. The loudspeaker module comprises a housing. A loudspeaker unit is accommodated in the housing. An electrical connection member which is a metal sheet is fixed on the housing. An inner bonding pad is disposed at one end of the electrical connection member, and an outer bonding pad is disposed at the other end of the electrical connection member. The inner bonding pad is located in the housing and is electrically connected to the loudspeaker unit. The outer bonding pad is exposed outside the housing and is electrically connected to a terminal circuit. The loudspeaker module of the present invention solves the technical problems in the prior art such as poor tone quality, low reliability, and a complicated assembling process of a loudspeaker module.

Abstract: A loudspeaker vibration system includes a diaphragm body part and a voice coil engaged at a lower side of the diaphragm body part. The diaphragm body part includes a rigid dome part, a silicon rubber membrane, and a plastic support engaged to an edge of the silicon rubber membrane. The dome part is engaged at a middle position of the silicon rubber membrane. A convex or concave bent ring part is provided at a location at an outer side of the dome part on the silicon rubber membrane. A spacing between the edge at an outer side of the dome part and an edge of the bent ring part closer to the dome part is in a range of 0.02 mm and 0.2 mm, and colloid is disposed in a gap between the dome part and the bent ring part. The loudspeaker vibration system according to the present disclosure may improve product sensitivity, reduce distortion and enhance acoustic performance of the product.

Abstract: A loudspeaker vibration system includes a diaphragm body part and a voice coil engaged at a lower side of the diaphragm body part. The diaphragm body part includes a rigid dome part, a silicon rubber membrane, and a plastic support engaged to an edge of the silicon rubber membrane. The dome part is engaged at a middle position of the silicon rubber membrane. A convex or concave bent ring part is provided at a location at an outer side of the dome part on the silicon rubber membrane. A spacing between the edge at an outer side of the dome part and an edge of the bent ring part closer to the dome part is in a range of 0.02 mm and 0.2 mm, and colloid is disposed in a gap between the dome part and the bent ring part. The loudspeaker vibration system according to the present disclosure may improve product sensitivity, reduce distortion and enhance acoustic performance of the product.