Abstract: Disclosed are nucleic acid-calcium phosphate nanoparticle complexes and application thereof in biomineralization. Specifically, disclosed are a biological mineralizer and a preparation method thereof. The mineralizer contains a complex formed by nucleic acid and amorphous calcium phosphate nanoparticles. Further, disclosed is a collagen fiber product containing the biological mineralizer or treated with the biological mineralizer, such as a medical device for being implanted into a patient. Further, disclosed is use of the biological mineralizer or the collagen fiber product in treatment of bone-associated diseases or disorders or improvement of bone conditions of patients. Further, disclosed is a method of using the biological mineralizer to induce biomimetic mineralization of collagen fibers or a preparation method of a mineralized collagen fiber product.

Abstract: The present disclosure is related to systems and methods for determining motion information of a subject. The method may include obtaining a first image of a subject. The first image may be obtained by performing a first scan on the subject using a first medical device of a first modality. The method may include obtaining a second image of the subject. The second image may be obtained by an image acquisition device during a second scan. The second scan may be performed on the subject using a second medical device of a second modality. The method may include generating a first model of the subject based on the first image. The method may include generating a second model of the subject based on the second image. The method may include determining motion information of the subject based on the first model and the second model.

Abstract: Delivery systems and their methods of use for delivering one or more therapeutic compounds to a user are described. A delivery system may include an implantable pump and an external actuator. The implantable pump may include an actuatable portion that may be actuated to dispense a volume of fluid. The external actuator may include a pusher configured to deform skin to engage an actuatable portion of the pump. The external actuator may also include a positioning magnet configured to magnetically attract a portion of the implantable pump such that the external actuator and the pump may be aligned prior to applying force to the portion of the skin between the external actuator and the actuatable portion of the pump.