Abstract: The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: This application discloses a method and apparatus for displaying a heat map, a computer device, and a readable storage medium, and relates to the field of interface display. The method includes: acquiring coordinate data of a heat point position, and transmitting the coordinate data to a graphics processing unit (GPU); converting a point primitive set corresponding to the coordinate data into a patch primitive set by the GPU; shading and rendering the patch primitive set by the GPU; and displaying a heat map corresponding to the heat point position. In a process of calculating and rendering the heat map, a central processing unit (CPU) only needs to confirm coordinate data of a heat point position before transmitting point primitives corresponding to the coordinate data to the GPU, and the heat map is calculated by the GPU for rendering.

Abstract: A small window exit method, applied to a terminal and includes: showing an exit region corresponding to a small window under the condition that the small window is displayed in a screen of the terminal; and executing an exit operation of the small window when a preset operation specific to the exit region is detected.

Abstract: This application discloses a method and apparatus for displaying a heat map, a computer device, and a readable storage medium, and relates to the field of interface display. The method includes: acquiring coordinate data of a heat point position, and transmitting the coordinate data to a graphics processing unit (GPU); converting a point primitive set corresponding to the coordinate data into a patch primitive set by the GPU; shading and rendering the patch primitive set by the GPU; and displaying a heat map corresponding to the heat point position. In a process of calculating and rendering the heat map, a central processing unit (CPU) only needs to confirm coordinate data of a heat point position before transmitting point primitives corresponding to the coordinate data to the GPU, and the heat map is calculated by the GPU for rendering.

Abstract: A vehicle comprising a Heating, Ventilation, and Air-Conditioning (HVAC) control assembly for navigating a menu associated with an HVAC system of the vehicle, the menu controlling operation of the HVAC system. A multiple input tactile control device, interface, and system is provided. In addition to providing input by rotating the tactile control device, a user can provide input via touching a touchpad, actuating the touchpad, and/or actuating the tactile control dial in the linear axial direction.