Abstract: An online system manages presentation of content items in various presentation contexts such as when the users are browsing pages or when the users have entered a search query. The online system trains a single unified machine learning model that predicts one or more likelihoods of a target event associated with presentation of a content item in the different presentation contexts. The learned model is applied to a set of candidate content items associated with a presentation opportunity in a specific context. Features that are inapplicable to the specific context may be masked when applying the model. The online system may select between the candidate content items based on the predicted likelihoods using the model trained across the multiple different contexts, such that the prediction for one context may be based in part on learned outcomes in other related contexts.

Abstract: Provided are a DNA nanovaccine, a preparation method therefor and the use thereof. The DNA nanovaccine comprises a DNA nanostructure, a tumor antigen polypeptide-DNA complex and an immunologic adjuvant, and the immunologic adjuvant comprises a double-stranded RNA immunologic adjuvant and/or a CpG immunologic adjuvant. In the present invention, a nanostructure is constructed, wherein the nanostructure is assembled from a DNA template, a DNA chain for assisting in folding and a capture DNA chain.

Abstract: An online concierge system allows a user to provide a nutritional goal and uses the nutritional goal as a constraint for selecting candidate orders to display to the user. From prior orders from the user, the online concierge system generates order templates including combinations of generic item descriptions corresponding to items previously included in orders from the user. From the order templates, the online concierge system generates candidate orders including specific items from a warehouse corresponding to the generic item descriptions. The online concierge system selects a set of the candidate orders that each include specific items with combined nutritional information satisfying the user's nutritional goal. Based on probabilities of the user purchasing different candidate orders of the set, the online concierge system selects one or more candidate orders of the set for display to the user.

Abstract: An online concierge system enables users to create lists of items and generate a link allowing other receiving users to access a list by selecting the link. When a receiving user selects the link, the online concierge system generates a user-specific list from the original list. The user-specific list includes user-specific items selected for the receiving user that replace items in the original list based on item availability to the receiving user, receiving user preferences, and other receiving user-specific criteria. The receiving user can then view the user-specific items in the user-specific list via an interface allowing the user-specific items in the user-specific list to be included in an order in a single interaction.

Abstract: The invention relates to ligands able to bind to microvesicles, comprising a plurality of metal(II)-dipicolylamine moieties and their use in the diagnosis or prognostic of disorders in a subject.

Abstract: The present disclosure discloses a method for safely preparing pimavanserin and tartrate thereof by using triphosgene. The synthesis route includes: Raw materials used in the method of the present disclosure are safe and inexpensive, thereby effectively reducing the production costs. The method of the present disclosure has mild reaction conditions, and avoids using phosgene, which is highly toxic and difficult to handle is avoided. Thus, the method is readily implemented industrially.

Abstract: The present disclosure discloses a method for safely preparing pimavanserin and tartrate thereof by using triphosgene. The synthesis route includes: Raw materials used in the method of the present disclosure are safe and inexpensive, thereby effectively reducing the production costs. The method of the present disclosure has mild reaction conditions, and avoids using phosgene, which is highly toxic and difficult to handle is avoided. Thus, the method is readily implemented industrially.

Abstract: In certain embodiments, the present invention provides a DNA nanostructure nanorobot comprising: a single stranded DNA scaffold strand of about 5,000 to 10,000 bases in length; a plurality of staple strands of DNA, wherein each staple strands are about 20 to 40 bases in length, wherein each staple strand has a unique sequence and is hybridized to a specific position on the DNA scaffold strand, wherein the plurality of staple strands hybridized to the DNA scaffold form a sheet having a top surface and a bottom surface; and one or more fastener strands of DNA, wherein the one or more fastener strands of DNA is capable of fastening the sheet into an origami structure.

Abstract: Embodiments of the present disclosure provide an array substrate and a manufacturing method for the same, and a display device. The array substrate includes a display region, and a package region arranged around the display region. The package region includes a plurality of separated signal line regions. In at least one of the signal line regions, at least two signal lines which are insulated from and overlapped with each other are arranged. In embodiments of the present disclosure, the coverage area of the signal lines on the package region may be effectively reduced as compared with the conventional structure in which the signal lines are arranged in one circuit layer. Therefore, the influence of the signal lines on the package region on the curing effect may be effectively reduced when the UV light is irradiated from the array substrate side for UV curing.

Abstract: A method is disclosed for preparing Ticagrelor using the compounds as represented by intermediates of formula (2), formula (1-b), formula (1-c), formula (1-d) and formula (1-e), wherein the definition of R is as described in the description, and also disclosed is a method for preparing the intermediate of formula (2) and the use thereof in the preparation of Ticagrelor.