Abstract: Disclosed is a compound having a structure in formula I. The compound of the present invention has good enzyme inhibitory activity against EGFR mutants (L858R/T790M/C797S, del19/T790M/C797S, del19/C797S, L858R/C797S), a weak inhibitory effect on wild-type EGFR, and good selectivity. The compound has significant inhibitory activity against the proliferation of EGFR mutant cells, and has potential application value in the treatment of diseases related to cell proliferation. The compound of the present invention has good solubility and permeability, good in-vivo metabolic stability, high in-vivo exposure, and high bioavailability, and is a potential pharmaceutical compound.

Abstract: Disclosed in the present disclosure are crystal forms of a fused ring compound, and a composition thereof, a preparation method therefor and use thereof. The crystal forms comprise a crystal form I, a crystal form II, a crystal form III, a crystal form IV and a crystal form V, which have, when using X-ray diffraction, characteristic diffraction peaks at about 11.3 degrees, 17.2 degrees and 21.1 degrees, at about 25.1 degrees, 21.2 degrees and 14.1 degrees, or at about 6.6 degrees, 13.4 degrees and 8.0 degrees, at about 11.8 degrees, 13.3 degrees and 16.7 degrees, and at about 6.5 degrees, 13.3 degrees and 20.0 degrees. The crystal form I or IV is obtained by dissolving a fused ring compound in a proper solvent, followed by stirring, filtering and drying. The use of crystal form I or crystal form IV in preparation of anti-cancer drugs for inhibiting phosphatidylinositol 3-kinase. The use thereof for targeted therapy for tumors, and for anti-inflammation or treatment of autoimmune diseases.

Abstract: The present invention provides a use of canagliflozin in preparation of an antitumor drug, especially in preparation of a drug for treating solid tumors. It has been proven through researches that canagliflozin has a significant down-regulation effect on immune checkpoint protein PD-L1 in various tumor cells and can effectively enhance the killing effect of T cells on tumor cells in a co-incubation model of T cells and tumor cells, thereby broadening a clinical application scope of the chemical drug canagliflozin in tumor immunotherapy. The present invention provides a new medical use of canagliflozin, and also provides new approaches and potential targets for the development of small molecular drugs based on PD-L1.

Abstract: The present disclosure relates to an unmanned lane keeping method and device, a computer device, and a storage medium. The method includes that: a vehicle road image collected by a data collector of the vehicle is received; the vehicle road image is transmitted to a preset DNN model of the vehicle for processing to obtain a steering wheel angle corresponding to the vehicle road image, wherein the DNN model of the vehicle is established by deep learning, and is used for characterizing a correspondence between the vehicle road image and the steering wheel angle; and the vehicle is controlled to keep driving in a corresponding lane according to the steering wheel angle.

Abstract: Provided are an automatic parking method and device. The automatic parking method includes: acquiring a global waypoint map of a parking lot where a vehicle is to be parked and position information of available parking spaces, and performing global path planning according to the global waypoint map and the available parking space position information; starting automatic driving according to the global path planning, acquiring vehicle visual information, and performing local path planning and obstacle avoidance processing according to the vehicle visual information; and searching for a parking space when automatically driving to the vicinity of the available parking spaces, and performing parking after finding an available parking space that satisfies a parking condition.

Abstract: An intersection traffic control method, apparatus and system are provided.

Abstract: Provided are a full-automatic parking method and system. The full-automatic parking method comprises: receiving a start instruction sent by a user, and activating an automatic parking system according to the start instruction; controlling a vehicle to automatically move forward and search, during moving, whether there is an available parking space at the left side or the right side of the vehicle, and when there is an available parking space, identifying basic information of the target parking space; planning a parking path according to the identified basic information of the target parking space, and obtaining a start point of parking and a parking path from the start point of parking to an end point of parking; controlling the vehicle to automatically move to the start point of parking; and controlling the vehicle to automatically park in the parking space according to the planned parking path.

Abstract: A polyfluoro-substituted aromatic heterocyclic derivative having the structure as represented by formula I or formula I?, wherein at least one of R1 and R2 is a fluorine atom, and at least two substituents of Rc, Rd, Re, and Rf are fluorine atoms; and an optical isomer of the derivative, or a pharmaceutically acceptable salt or solvate of the same, or a pharmaceutically acceptable salt or solvate of the optical isomer of the same. A composition containing the polyfluoro-substituted aromatic heterocyclic derivative and an application of the composition in preparing an anti-tumour medicament. The compound provides significant inhibitory effects with respect to Akt1 and demonstrates strong proliferation inhibitory activity with respect to tumour cell lines such as an ovarian cancer cell line, a colon cancer cell line, and a prostate cancer cell line.

Abstract: Provided are a diagonal parking space detection method and device, and an automatic parking method and system. The diagonal parking space detection method includes: operation S11, determining a target diagonal parking space in multiple diagonal parking spaces arranged along a reference line, wherein the target diagonal parking space is located between a first reference parking space and a second reference parking space; operation S12, detecting a first reference point identifying an intersection point between the first reference parking space and the reference line; operation S13, calculating a slope of the target diagonal parking space; operation S14, detecting a second reference point identifying an intersection point between the second reference parking space and the reference line; and operation S15, calculating a width of the target diagonal parking space.

Abstract: The present disclosure provides a use of a nicotinamide composition in preparation of a drug for treating hand-foot skin reaction (HFSR) induced by sorafenib, the composition being consisted of nicotinamide and sorafenib in a dosage ratio of 2:3. The composition provided by the present disclosure can alleviate the HFSR caused by excessive keratinization induced by sorafenib. This protective effect is achieved by inhibiting HB-EGF/SIRT1 pathway. The present disclosure provides a mechanism of sorafenib-induced HFSR, i.e., the excessive activation of the HB-EGF/SIRT1 pathway, thereby providing a theoretical foundation for clinical research of sorafenib-induced HFSR. The present disclosure also provides a drug that can effectively treat sorafenib-induced HFSR, thereby greatly broadening the clinical application of sorafenib. Nicotinamide is highly clinically feasible due to its moderate price, and thus can be prepared in any suitable formulation according to the requirements.

Abstract: The present invention provides a use of canagliflozin in preparation of an antitumor drug, especially in preparation of a drug for treating solid tumors. It has been proven through researches that canagliflozin has a significant down-regulation effect on immune checkpoint protein PD-L1 in various tumor cells and can effectively enhance the killing effect of T cells on tumor cells in a co-incubation model of T cells and tumor cells, thereby broadening a clinical application scope of the chemical drug canagliflozin in tumor immunotherapy. The present invention provides a new medical use of canagliflozin, and also provides new approaches and potential targets for the development of small molecular drugs based on PD-L1.

Abstract: Disclosed is a device which incorporates a process by which an absorptive material is used to absorb fluid, the weight of said fluid causes the device to move without any outside energy source. The fluid, by way of evaporation or by being absorbed into another absorptive material, substantially disappears, causing the device to return back to its starting position on its own, and repeat the process. The fluid, which is stocked in a holding area, remains stagnant, until the device in its starting position is made in contact with the fluid by use of a counterweight, and thereby absorbs the fluid, however, when the device is saturated, the greater volume of absorbent on one side causes the device to move to its activated position. In its activated position, the device is not exposed to the fluid and therefore remains until the fluid is evaporated or absorbed into another absorbent.

Abstract: Provided are a diagonal parking space detection method and device, and an automatic parking method and system. The diagonal parking space detection method includes: operation S11, determining a target diagonal parking space in multiple diagonal parking spaces arranged along a reference line, wherein the target diagonal parking space is located between a first reference parking space and a second reference parking space; operation S12, detecting a first reference point identifying an intersection point between the first reference parking space and the reference line; operation S13, calculating a slope of the target diagonal parking space; operation S14, detecting a second reference point identifying an intersection point between the second reference parking spacer and the reference line; and operation S15, calculating a width of the target diagonal parking space.

Abstract: Provided are a full-automatic parking method and system. The full-automatic parking method comprises: receiving a start instruction sent by a user, and activating an automatic parking system according to the start instruction; controlling a vehicle to automatically move forward and search, during moving, whether there is an available parking space at the left side or the right side of the vehicle, and when there is an available parking space, identifying basic information of the target parking space; planning a parking path according to the identified basic information of the target parking space, and obtaining a start point of parking and a parking path from the start point of parking to an end point of parking; controlling the vehicle to automatically move to the start point of parking; and controlling the vehicle to automatically park in the parking space according to the planned parking path.

Abstract: The present disclosure relates to an unmanned lane keeping method and device, a computer device, and a storage medium. The method includes that: a vehicle road image collected by a data collector of the vehicle is received; the vehicle road image is transmitted to a preset DNN model of the vehicle for processing to obtain a steering wheel angle corresponding to the vehicle road image, wherein the DNN model of the vehicle is established by deep learning, and is used for characterizing a correspondence between the vehicle road image and the steering wheel angle; and the vehicle is controlled to keep driving in a corresponding lane according to the steering wheel angle.

Abstract: The present disclosure provides a use of a nicotinamide composition in preparation of a drug for treating hand-foot skin reaction (HFSR) induced by sorafenib, the composition being consisted of nicotinamide and sorafenib in a dosage ratio of 2:3. The composition provided by the present disclosure can alleviate the HFSR caused by excessive keratinization induced by sorafenib. This protective effect is achieved by inhibiting HB-EGF/SIRT1 pathway. The present disclosure provides a mechanism of sorafenib-induced HFSR, i.e., the excessive activation of the HB-EGF/SIRT1 pathway, thereby providing a theoretical foundation for clinical research of sorafenib-induced HFSR. The present disclosure also provides a drug that can effectively treat sorafenib-induced HFSR, thereby greatly broadening the clinical application of sorafenib. Nicotinamide is highly clinically feasible due to its moderate price, and thus can be prepared in any suitable formulation according to the requirements.

Abstract: Provided are an automatic parking method and device. The automatic parking method includes: acquiring a global waypoint map of a parking lot where a vehicle is to be parked and position information of available parking spaces, and performing global path planning according to the global waypoint map and the available parking space position information; starting automatic driving according to the global path planning, acquiring vehicle visual information, and performing local path planning and obstacle avoidance processing according to the vehicle visual information; and searching for a parking space when automatically driving to the vicinity of the available parking spaces, and performing parking after finding an available parking space that satisfies a parking condition.

Abstract: A polyfluoro-substituted aromatic heterocyclic derivative having the structure as represented by formula I or formula I?, wherein at least one of Ri and R2 is a fluorine atom, and at least two substituents of Rc, Rd, Re, and Rf are fluorine atoms; and an optical isomer of the derivative, or a pharmaceutically acceptable salt or solvate of the same, or a pharmaceutically acceptable salt or solvate of the optical isomer of the same. A composition containing the polyfluoro-substituted aromatic heterocyclic derivative and an application of the composition in preparing an anti-tumour medicament. The compound provides significant inhibitory effects with respect to Aktl and demonstrates strong proliferation inhibitory activity with respect to tumour cell lines such as an ovarian cancer cell line, a colon cancer cell line, and a prostate cancer cell line.

Abstract: Disclosed are new substituted nitrogen-containing heterocyclic derivatives represented by formula (I) as AKT inhibitors, optical isomers, pharmaceutically acceptable salts or solvates thereof, wherein the definition of R1, R2, R3, R4, R5, R6, ring A, ring C, B, Q, Y, Z and m is shown in the description for details. In addition, medicaments comprising the derivatives as active components are also disclosed, which can be useful for treating proliferative diseases, such as cancer and inflammation, especially diseases relating to AKT kinase.

Abstract: Disclosed are a tripeptide epoxyketone compound, a preparation method thereof, and a use thereof in the preparation of anti-tumor drugs.