Abstract: Disclosed are a fusion protein, and a preparation method and use thereof, which belong to the field of biomedicine technologies. The fusion protein comprises a polypeptide specifically bound to a KRas protein, a specific tumor-cell-penetrating peptide and a lysosome recognition peptide. The fusion protein with tumor targeting, penetrability and specific protein degradation is designed and constructed direct to an undruggable protein for the first time, thus providing a new idea for development of an anti-cancer targeted drug. Different from the prior art in which one molecule can only target one target protein, the fusion protein can simultaneously induce degradation of wild-type and mutant-type KRas proteins. Meanwhile, the fusion protein can improve the sensitivity of the KRas mutant-type tumor to the tumor-targeted drug by inducing degradation of KRas, thus expanding an application range of existing anti-cancer targeted drugs and having important significance in tumor clinic treatment.

Abstract: Disclosed are a bismuth sodium potassium titanate-barium titanate (BNKT-BT)-based composite ceramic material with high depolarization temperature and a preparation method thereof, belonging to the technical field of piezoelectric ceramics of electronic materials. The chemical general formula of the BNKT-BT based composite ceramic material is: 0.85(Bi0.5Na0.5)TiO3-0.11(Bi0.5K0.5)TiO3-0.04BaTiO3-xZnO, where 0.1?x?0.3. The composite ceramic material takes BNKT-BT ceramics as the substrate, and single-phase ZnO is embedded in the middle of the substrate to form a 0-3 composite structure.

Abstract: The present invention relates to a data-driven rapid traceability method for air pollution in small-scale regions, comprising: localizing the land use type information of air pollution diffusion model and simulating the meteorological field; according to local meteorological conditions, constructing the meteorological scenarios with the combination of equidistantly divided meteorological parameters; forming the pollution traceability database by the traceability results which is obtained by stimulating the meteorological scenarios via the air pollution diffusion simulation platform; building the data-driven model by taking the pollution traceability database as training data for fitting; realizing the rapid pollution traceability by matching the pollution traceability database or triggering the data-driven model by the real-time meteorological conditions.