Patents by Inventor Qiaoning HE

Qiaoning HE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12146132
    Abstract: Genetically modified Zymomonas mobilis to utilize inorganic N source, methods and uses thereof are provided. The genetically modified Z. mobilis has a genome with the knockout of a locus ZMO1107 from Z. mobilis ZM4 could ferment inorganic N source.
    Type: Grant
    Filed: April 3, 2024
    Date of Patent: November 19, 2024
    Assignee: Hubei University
    Inventors: Shihui Yang, Mimi Hu, Qiaoning He
  • Publication number: 20240352403
    Abstract: Genetically modified Zymomonas mobilis to utilize inorganic N source, methods and uses thereof are provided. The genetically modified Z. mobilis has a genome with the knockout of a locus ZMO1107 from Z. mobilis ZM4 could ferment inorganic N source.
    Type: Application
    Filed: April 3, 2024
    Publication date: October 24, 2024
    Applicant: Hubei University
    Inventors: Shihui YANG, Mimi HU, Qiaoning HE
  • Patent number: 12098410
    Abstract: Recombinant Zymomonas mobilis for producing ethylene glycol, method and uses thereof are provided. The recombinant Zymomonas mobilis carries and expresses genes related to a synthesis pathway of xylonic acid and genes related to a synthesis pathway of ethylene glycol.
    Type: Grant
    Filed: December 31, 2023
    Date of Patent: September 24, 2024
    Assignee: Hubei University
    Inventors: Shihui Yang, Xiongying Yan, Mian Li, Xia Wang, Qiaoning He
  • Publication number: 20240301448
    Abstract: Recombinant Zymomonas mobilis for producing ethylene glycol, method and uses thereof are provided. The recombinant Zymomonas mobilis carries and expresses genes related to a synthesis pathway of xylonic acid and genes related to a synthesis pathway of ethylene glycol.
    Type: Application
    Filed: December 31, 2023
    Publication date: September 12, 2024
    Applicant: Hubei University
    Inventors: Shihui YANG, Xiongying YAN, Mian LI, Xia WANG, Qiaoning HE
  • Publication number: 20240093247
    Abstract: A genetically engineered strain of Z. mobilis and uses thereof are provided. The genetically engineered strain named ZMNP is obtained by knockouts of four endogenous plasmids of pZM32, pZM32, pZM36, pZM33, and pZM39 from strain ZM4-Cas12a. ZMNP contains a reduced genome and has a series of excellent traits, such as high transformation efficiency, enhanced tolerance to inhibitors, improved capability to use secondary mother liquor and other excellent performance. ZMNP can be used as a chassis cell to construct diverse cell factories for biochemical production using different feedstocks especially the lignocellulosic biomass.
    Type: Application
    Filed: September 18, 2023
    Publication date: March 21, 2024
    Applicant: Hubei University
    Inventors: Shihui YANG, Binan GENG, Qiaoning HE, Jun DU, Mian LI
  • Patent number: 11879124
    Abstract: A construction method of a regulation system for gene expression in Zymomonas mobilis and applications are provided. The T7 expression system in Zymomonas mobilis has been constructed. The T7 expression system is used to construct a regulation circuit, help analyze the function of toxic genes and realize the regulation of metabolic pathways in Zymomonas mobilis. At the same time, shuttle plasmids that can be used in Zymomonas mobilis and Escherichia coli, also be constructed to facilitate the construction of plasmid and improve the expression efficiency of foreign genes in Zymomonas mobilis, laying a foundation for subsequent protein expression and secretion and metabolic engineering pathway optimization regulation.
    Type: Grant
    Filed: May 10, 2023
    Date of Patent: January 23, 2024
    Assignee: Hubei University
    Inventors: Shihui Yang, Yi Wang, Yunhao Chen, Yueyue Chen, Qiaoning He
  • Publication number: 20230407242
    Abstract: The disclosure relates to a genetically engineered Z. mobilis ZM4 for producing PHB and uses thereof. A variety of strains capable of producing both PHB and ethanol that are constructed by integrating three codon-optimized essential genes for exogenous PUB biosynthesis, phaA, phaB and phaC, together with a tetracycline-inducible promoter Ptet into the genome of ZM4.
    Type: Application
    Filed: December 27, 2022
    Publication date: December 21, 2023
    Applicant: Hubei University
    Inventors: Shihui YANG, Qiaoning HE, Yang LI
  • Publication number: 20230287398
    Abstract: A construction method of a tight regulation system for gene expression in Zywmmonas mobilis and applications are provided. The T7 expression system in Zymomonas mobilis has been constructed. The T7 expression system is used to construct a tight regulation circuit, help analyze the function of toxic genes and realize the tight regulation of metabolic pathways in Zymomonas mobilis. At the same time, a shuttle plasmids that can be used in Zymomonas mobilis and Escherichia coli., also be constructed to facilitate the construction of plasmid and improve the expression efficiency of foreign genes in Zymomonas mobilis, laying a foundation for subsequent protein expression and secretion and metabolic engineering pathway optimization regulation.
    Type: Application
    Filed: May 10, 2023
    Publication date: September 14, 2023
    Applicant: Hubei University
    Inventors: Shihui YANG, Yi WANG, Yunhao CHEN, Yueyue CHEN, Qiaoning HE