Patents by Inventor Qihong Huang

Qihong Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210242793
    Abstract: A multi-function switch has a Junction-Field Effect Transistor (JFET) that outputs a voltage for both charging and timing/sense the synchronous rectifier controller. Current is provided to a synchronous rectifier controller from a JET having its drain conductively coupled to the drain electrode of the secondary side rectifying MOSFET, wherein the current from the source of the JET is used for both timing/sense and powering the synchronous rectifier controller. The JFET is biased for a fixed output with its source to gate voltage at a turn on threshold voltage of the JFET for charging. The JFET is fully conducting from the secondary side of transformer with a small voltage drop across the drain to source electrode of the secondary side rectifying MOSFET for timing/sense.
    Type: Application
    Filed: January 30, 2020
    Publication date: August 5, 2021
    Inventors: Jian Yin, Qihong Huang
  • Patent number: 10763221
    Abstract: A high voltage (HV) converter implemented on a printed circuit board (PCB) includes a double diffused metal oxide semiconductor (DMOS) package comprising a lead frame and a main DMOS chip. The lead frame includes a gate section electrically connected to a gate electrode of the main DMOS chip, a source section electrically connected to a source electrode of the main DMOS chip and a drain section electrically connected to a drain electrode of the main DMOS chip. The PCB layout includes a large area source copper pad attached to and overlapping the source section of the DMOS package to facilitate cooling and a small area drain copper pad attached to and overlapping the drain section of the DMOS package to reduce electromagnetic interference (EMI) noise.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: September 1, 2020
    Assignee: ALPHA AND OMEGA SEMICONDUCTOR (CAYMAN), LTD.
    Inventors: Zhiqiang Niu, Kuang Ming Chang, Lin Chen, Ning Sun, QiHong Huang, Tzu-Hsin Lu
  • Patent number: 10745761
    Abstract: The present invention relates to methods and systems for high risk screening, diagnosis, prognosis, and surveillance of lung cancer. Accordingly, in one aspect, the invention provides a method for diagnosing or evaluating whether a subject has, or is at risk of having, lung cancer such as NSCLS. The method comprises obtaining a first expression level of the AKAP4 gene of a population of cells from the blood of a test subject; and comparing the first expression level with a first predetermined reference value. A difference between the first expression level and first predetermined reference value correlates with a diagnosis or evaluation of a lung cancer.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: August 18, 2020
    Assignees: Valley Health System, The Wistar Institute of Anatomy and Biology
    Inventors: Kiranmai Gumireddy, Qihong Huang, Louise C. Showe, Ganepola A Ganepola
  • Publication number: 20190385953
    Abstract: A high voltage (HV) converter implemented on a printed circuit board (PCB) includes a double diffused metal oxide semiconductor (DMOS) package comprising a lead frame and a main DMOS chip. The lead frame includes a gate section electrically connected to a gate electrode of the main DMOS chip, a source section electrically connected to a source electrode of the main DMOS chip and a drain section electrically connected to a drain electrode of the main DMOS chip. The PCB layout includes a large area source copper pad attached to and overlapping the source section of the DMOS package to facilitate cooling and a small area drain copper pad attached to and overlapping the drain section of the DMOS package to reduce electromagnetic interference (EMI) noise.
    Type: Application
    Filed: August 29, 2019
    Publication date: December 19, 2019
    Applicant: Alpha and Omega Semiconductor (Cayman) Ltd.
    Inventors: Zhiqiang Niu, Kuang Ming Chang, Lin Chen, Ning Sun, QiHong Huang, Tzu-Hsin Lu
  • Patent number: 10438900
    Abstract: A high voltage (HV) converter implemented on a printed circuit board (PCB) includes a double diffused metal oxide semiconductor (DMOS) package comprising a lead frame and a main DMOS chip. The lead frame includes a gate section electrically connected to a gate electrode of the main DMOS chip, a source section electrically connected to a source electrode of the main DMOS chip and a drain section electrically connected to a drain electrode of the main DMOS chip. The PCB layout includes a large area source copper pad attached to and overlapping the source section of the DMOS package to facilitate cooling and a small area drain copper pad attached to and overlapping the drain section of the DMOS package to reduce electromagnetic interference (EMI) noise.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: October 8, 2019
    Assignee: Alpha and Omega Semiconductor (Cayman) Ltd.
    Inventors: Zhiqiang Niu, Kuang Ming Chang, Lin Chen, Ning Sun, QiHong Huang
  • Publication number: 20190304924
    Abstract: A high voltage (HV) converter implemented on a printed circuit board (PCB) includes a double diffused metal oxide semiconductor (DMOS) package comprising a lead frame and a main DMOS chip. The lead frame includes a gate section electrically connected to a gate electrode of the main DMOS chip, a source section electrically connected to a source electrode of the main DMOS chip and a drain section electrically connected to a drain electrode of the main DMOS chip. The PCB layout includes a large area source copper pad attached to and overlapping the source section of the DMOS package to facilitate cooling and a small area drain copper pad attached to and overlapping the drain section of the DMOS package to reduce electromagnetic interference (EMI) noise.
    Type: Application
    Filed: March 29, 2018
    Publication date: October 3, 2019
    Applicant: Alpha and Omega Semiconductor (Cayman) Ltd.
    Inventors: Zhiqiang Niu, Kuang Ming Chang, Lin Chen, Ning Sun, QiHong Huang, Tzu-Hsin Lu
  • Publication number: 20190177799
    Abstract: The present invention relates to methods and systems for high risk screening, diagnosis, prognosis, and surveillance of lung cancer. Accordingly, in one aspect, the invention provides a method for diagnosing or evaluating whether a subject has, or is at risk of having, lung cancer such as NSCLS. The method comprises obtaining a first expression level of the AKAP4 gene of a population of cells from the blood of a test subject; and comparing the first expression level with a first predetermined reference value. A difference between the first expression level and first predetermined reference value correlates with a diagnosis or evaluation of a lung cancer.
    Type: Application
    Filed: June 2, 2015
    Publication date: June 13, 2019
    Applicants: Valley Health System, The Wistar Institute
    Inventors: Kiranmai Gumireddy, Qihong Huang, Louise C. Showe, Ganepola A. Ganepola
  • Patent number: 10250152
    Abstract: A flyback converter implements a Forced Zero Voltage Switching (ZVS) timing control by detecting a positive current excursion of the secondary winding current as the synchronous rectifier turn off trigger. The synchronous rectifier switch is turned on near the end of the switching cycle or the on duration is extended to develop a current ripple on the secondary winding current. The control circuit of the flyback converter detects a positive current excursion on the secondary winding current to turn off the synchronous rectifier and to start the next switching cycle. At this point, the voltage across the primary switch has been discharged and the primary switch can be turned on with zero drain-to-source voltage. In other embodiments, zero voltage switching for the off-transition of the primary switch is realized by coupling a capacitor across the primary switch or by coupling a capacitor across the primary winding, or both.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: April 2, 2019
    Assignee: Alpha and Omega Semiconductor Incorporated
    Inventors: Kuang Ming Chang, Lin Chen, Qihong Huang
  • Publication number: 20180254712
    Abstract: A flyback converter implements a Forced Zero Voltage Switching (ZVS) timing control by detecting a positive current excursion of the secondary winding current as the synchronous rectifier turn off trigger. The synchronous rectifier switch is turned on near the end of the switching cycle or the on duration is extended to develop a current ripple on the secondary winding current. The control circuit of the flyback converter detects a positive current excursion on the secondary winding current to turn off the synchronous rectifier and to start the next switching cycle. At this point, the voltage across the primary switch has been discharged and the primary switch can be turned on with zero drain-to-source voltage. In other embodiments, zero voltage switching for the off-transition of the primary switch is realized by coupling a capacitor across the primary switch or by coupling a capacitor across the primary winding, or both.
    Type: Application
    Filed: May 4, 2018
    Publication date: September 6, 2018
    Inventors: Kuang Ming Chang, Lin Chen, Qihong Huang
  • Patent number: 9998021
    Abstract: A flyback converter implements a Forced Zero Voltage Switching (ZVS) timing control by detecting a positive current excursion of the secondary winding current as the synchronous rectifier turn off trigger. The synchronous rectifier switch is turned on near the end of the switching cycle or the on duration is extended to develop a current ripple on the secondary winding current. The control circuit of the flyback converter detects a positive current excursion on the secondary winding current to turn off the synchronous rectifier and to start the next switching cycle. At this point, the voltage across the primary switch has been discharged and the primary switch can be turned on with zero drain-to-source voltage. In other embodiments, zero voltage switching for the off-transition of the primary switch is realized by coupling a capacitor across the primary switch or by coupling a capacitor across the primary winding, or both.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: June 12, 2018
    Assignee: Alpha and Omega Semiconductor Incorporated
    Inventors: Kuang Ming Chang, Lin Chen, Qihong Huang
  • Publication number: 20180115252
    Abstract: A flyback converter implements a Forced Zero Voltage Switching (ZVS) timing control by detecting a positive current excursion of the secondary winding current as the synchronous rectifier turn off trigger. The synchronous rectifier switch is turned on near the end of the switching cycle or the on duration is extended to develop a current ripple on the secondary winding current. The control circuit of the flyback converter detects a positive current excursion on the secondary winding current to turn off the synchronous rectifier and to start the next switching cycle. At this point, the voltage across the primary switch has been discharged and the primary switch can be turned on with zero drain-to-source voltage. In other embodiments, zero voltage switching for the off-transition of the primary switch is realized by coupling a capacitor across the primary switch or by coupling a capacitor across the primary winding, or both.
    Type: Application
    Filed: October 25, 2016
    Publication date: April 26, 2018
    Inventors: Kuang Ming Chang, Lin Chen, Qihong Huang
  • Patent number: 9899931
    Abstract: A flyback converter implements a Forced Zero Voltage Switching (ZVS) timing control by detecting a positive current excursion of the secondary winding current as the synchronous rectifier turn off trigger. The synchronous rectifier switch is turned on near the end of the switching cycle or the on duration is extended to develop a current ripple on the secondary winding current. The control circuit of the flyback converter detects a positive current excursion on the secondary winding current to turn off the synchronous rectifier and to start the next switching cycle. At this point, the voltage across the primary switch has been discharged and the primary switch can be turned on with zero drain-to-source voltage. In other embodiments, zero voltage switching for the off-transition of the primary switch is realized by coupling a capacitor across the primary switch or by coupling a capacitor across the primary winding, or both.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: February 20, 2018
    Assignee: Alpha and Omega Semiconductor Incorporated
    Inventors: Kuang Ming Chang, Lin Chen, Qihong Huang
  • Publication number: 20170198359
    Abstract: Compositions and methods for diagnosing and treating breast cancer, including metastatic breast cancer, are provided. In one aspect, a diagnostic composition comprising a reagent which is capable of specifically complexing with, or identifying, GABRA3 is provided. In another aspect, a method of detecting breast cancer in a subject comprising measuring the level of GABRA3 in a biological sample from the subject is provided. In yet another aspect, a method of treating breast cancer is provided, the method comprising: measuring the level of GABRA3 in a biological sample from a subject and treating the subject with a reagent that inhibits the action of GABA when GABRA3 is detected in the sample or when there is an increase in the level of GABRA3 in the sample as compared to a control sample from a healthy subject.
    Type: Application
    Filed: January 3, 2017
    Publication date: July 13, 2017
    Inventors: Qihong Huang, Kazuko Nishikura, Kiranmai Gumireddy
  • Publication number: 20140255386
    Abstract: The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
    Type: Application
    Filed: July 24, 2012
    Publication date: September 11, 2014
    Applicants: NORTH CAROLINA STATE UNIVERSITY, THE WISTAR INSTITUTE
    Inventors: Qihong Huang, Alexander Deiters, Kiranmai Gumireddy
  • Publication number: 20130023498
    Abstract: The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
    Type: Application
    Filed: June 20, 2012
    Publication date: January 24, 2013
    Inventors: Qihong Huang, Alexander Deiters, Kiranmai Gumireddy
  • Patent number: 8338392
    Abstract: The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: December 25, 2012
    Assignees: The Wistar Institute, North Carolina State University
    Inventors: Qihong Huang, Alexander Deiters, Kiranmai Gumireddy
  • Patent number: 8119404
    Abstract: The invention provides polypeptides comprising inhibitor of apoptosis protein (IAP) family members, such as BmIAP initially derived from Bombyx mori BmN cells, and nucleic acids encoding them, and methods for making and using these compositions, including their use for inhibiting apoptosis.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: February 21, 2012
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Qihong Huang, John C. Reed, Bruce D. Hammock, Quinn L. Deveraux, Susumu Maeda, Hiroko Maeda, legal representative
  • Publication number: 20120010177
    Abstract: The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
    Type: Application
    Filed: August 1, 2011
    Publication date: January 12, 2012
    Applicant: The Wistar Institute / North Carolina State University
    Inventors: Qihong Huang, Alexander Deiters, Kiranmai Gumireddy
  • Publication number: 20110064828
    Abstract: The present invention generally relates to pharmacology and, in particular, to the treatment of tumors and other conditions. In some aspects, the invention is directed to the treatment of subjects having tumors or cancers that are metastatic. Surprisingly, it has been found that certain compositions comprising oxidized glutathione-based compounds are able to effectively treat such cancers by inhibiting cell migration and/or invasion processes, and thus, inhibiting tumor cell metastases. Without being bound by any theory, it is believed that such compositions are effective since the compositions are able to suppress the activation of critical signaling pathways within cells that are used for cell migration, such as the ErbB2 and/or phosphoinositide-3 kinase (PI3K) pathways, including the downstream RhoA and AKT pathways.
    Type: Application
    Filed: September 10, 2010
    Publication date: March 17, 2011
    Applicants: Novelos Therapeutics, Incorporated, The Wistar Institute
    Inventors: Chris Pazoles, Evgeny Vulfson, Qihong Huang
  • Publication number: 20100317628
    Abstract: The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
    Type: Application
    Filed: February 20, 2009
    Publication date: December 16, 2010
    Inventors: Qihong Huang, Alexander Deiters, Kiranmai Gumireddy