Patents by Inventor Qihua C. Cai

Qihua C. Cai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Zinc finger nuclease-mediated homologous recombination
    Patent number: 10669551
    Abstract: Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into a predetermined target site in a plant genome.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: June 2, 2020
    Assignees: Dow AgroSciences LLC, Sangamo Therapeutics, Inc.
    Inventors: Qihua C. Cai, Jeffrey C. Miller, William M. Ainley, Robbi J. Garrison, Joseph F. Petolino, Beth C. Rubin-Wilson, Lisa L. Schulenberg, Andrew F. Worden
  • Optimized non-canonical zinc finger proteins
    Patent number: 10662434
    Abstract: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: May 26, 2020
    Assignees: Dow AgroSciences LLC, Sangamo Therapeutics, Inc.
    Inventors: Qihua C. Cai, Vipula K. Shukla, Joseph F. Petolino, Lisa W. Baker, Robbi J. Garrison, Ryan C. Blue, Jon C. Mitchell, Nicole L. Arnold, Sarah E. Worden, Jeffrey C. Miller, Fyodor Urnov
  • ZINC FINGER NUCLEASE-MEDIATED HOMOLOGOUS RECOMBINATION
    Publication number: 20160326537
    Abstract: Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into a predetermined target site in a plant genome.
    Type: Application
    Filed: July 22, 2016
    Publication date: November 10, 2016
    Inventors: Qihua C. Cai, Jeffrey C. Miller, William M. Ainley, Robbi J. Garrison, Joseph F. Petolino, Beth C. Rubin-Wilson, Lisa L. Schulenberg, Andrew F. Worden
  • OPTIMIZED NON-CANONICAL ZINC FINGER PROTEINS
    Publication number: 20160130314
    Abstract: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.
    Type: Application
    Filed: November 12, 2015
    Publication date: May 12, 2016
    Inventors: Qihua C. Cai, Vipula K. Shukla, Joseph F. Petolino, Lisa W. Baker, Robbi J. Garrison, Ryan C. Blue, Jon C. Mitchell, Nicole L. Arnold, Sarah E. Worden, Jeffrey C. Miller, Fyodor Urnov
  • Protein production in plant cells and associated methods and compositions
    Patent number: 9249422
    Abstract: The present invention relates to methods and compositions for the expression of protein. Embodiments of methods may comprise the cleavage and repair of a nucleotide sequence encoding a highly expressed protein leading to a reduction in the expression of the highly expressed protein.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: February 2, 2016
    Assignee: Dow AgroSciences LLC
    Inventors: Joseph F. Petolino, Qihua C. Cai, Weiting W. Ni
  • Optimized non-canonical zinc finger proteins
    Patent number: 9187758
    Abstract: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: November 17, 2015
    Assignees: Sangamo BioSciences, Inc., Dow AgroSciences LLC
    Inventors: Qihua C. Cai, Vipula K. Shukla, Joseph F. Petolino, Lisa W. Baker, Robbi J. Garrison, Ryan C. Blue, Jon C. Mitchell, Nicole L. Arnold, Sarah E. Worden, Jeffrey Miller, Fyodor Urnov
  • Optimized non-canonical zinc finger proteins
    Patent number: 8921112
    Abstract: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: December 30, 2014
    Assignees: Dow AgroSciences LLC, Sangamo BioSciences, Inc.
    Inventors: Qihua C. Cai, Vipula K. Shukla, Joseph F. Petolino, Lisa W. Baker, Robbi J. Garrison, Ryan C. Blue, Jon C. Mitchell, Nicole L. Arnold, Sarah E. Worden, Jeffrey Miller, Fyodor Urnov
  • PROTEIN PRODUCTION IN PLANT CELLS AND ASSOCIATED METHODS AND COMPOSITIONS
    Publication number: 20110008833
    Abstract: The present invention relates to methods and compositions for the expression of protein. Embodiments of methods may comprise the cleavage and repair of a nucleotide sequence encoding a highly expressed protein leading to a reduction in the expression of the highly expressed protein.
    Type: Application
    Filed: September 9, 2009
    Publication date: January 13, 2011
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Joseph F. Petolino, Qihua C. Cai, Weiting W. Ni
  • Optimized non-canonical zinc finger proteins
    Publication number: 20090111188
    Abstract: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.
    Type: Application
    Filed: October 1, 2008
    Publication date: April 30, 2009
    Inventors: Qihua C. Cai, Vipula K. Shukla, Joseph F. Petolino, Lisa W. Baker, Robbi J. Garrison, Ryan C. Blue, Jon C. Mitchell, Nicole L. Arnold, Sarah E. Worden, Jeffrey Miller, Fyodor Urnov
  • Optimized non-canonical zinc finger proteins
    Publication number: 20080182332
    Abstract: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.
    Type: Application
    Filed: December 13, 2007
    Publication date: July 31, 2008
    Inventors: Qihua C. Cai, Vipula K. Shukla, Joseph F. Petolino, Lisa W. Baker, Robbi J. Garrison, Ryan C. Blue, Jon C. Mitchell, Nicole L. Arnold, Sarah E. Worden, Jeffrey Miller, Fyodor Urnov