Patents by Inventor Qihui Shi
Qihui Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11098274Abstract: Provided are a method for detecting a free rare tumor cell in a human biological fluid sample and assay kit. Specifically, the method of the invention determines the existence of an active tumor cell in a biological fluid sample of a cancer patient by detecting and confirming the existence of glucose absorption capability of a karyocyte and expression of a leukocyte marker (CD45).Type: GrantFiled: April 29, 2016Date of Patent: August 24, 2021Assignee: SHANGHAI QIANYI BIOTECH CO. LTD.Inventors: Qihui Shi, Shun Lu, Yuliang Deng, Yin Tang
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Publication number: 20210231679Abstract: A marker of fetal trophoblast cells, an identification method, a detection kit and the use thereof. The identification method comprises performing dyeing treatment on a sample containing fetal trophoblast cells with a fluorescence-labeled HK2 antibody substance, and then performing fluorescence detection, wherein HK2 positive cells are target cells. The kit comprises a fluorescence-labeled HK2 antibody substance and a cell nucleus dye. The above-mentioned technical solution can sensitively and reliably detect fetal trophoblast cells in the cervical mucus or blood samples of pregnant women in the first trimester, and especially can be used for prenatal diagnosis in early pregnancy.Type: ApplicationFiled: April 13, 2021Publication date: July 29, 2021Inventors: Qihui Shi, Chunying Wang
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Patent number: 11047858Abstract: A method for detecting and typing rare tumor cells having high metabolic activity in a body fluid sample, comprising the following steps: incubating nucleated cells in a body fluid sample with a first metabolic marker and a second metabolic marker capable of producing fluorescence signals; detecting, by means of high-throughput imaging, uptake of all the fluorescence signals of the metabolic markers by cells, so as to determine the energy metabolism mode and intensity of the cells; and identifying and typing, according to the fluorescence signals of the metabolic marker combination, tumor cells having high metabolic activity in the body fluid sample. Further provided is a kit used for the detecting and typing method, comprising a microwell array chip, a first metabolic marker and a second metabolic marker capable of producing fluorescence signals, and fluorescence-labeled antibodies specific to leukocyte common antigen.Type: GrantFiled: May 5, 2020Date of Patent: June 29, 2021Assignee: Suzhou Junhui Biotechnology Co., Ltd.Inventors: Qihui Shi, Yuliang Deng, Yin Tang, Zhuo Wang
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Publication number: 20200264180Abstract: A method for detecting and typing rare tumor cells having high metabolic activity in a body fluid sample, comprising the following steps: incubating nucleated cells in a body fluid sample with a first metabolic marker and a second metabolic marker capable of producing fluorescence signals; detecting, by means of high-throughput imaging, uptake of all the fluorescence signals of the metabolic markers by cells, so as to determine the energy metabolism mode and intensity of the cells; and identifying and typing, according to the fluorescence signals of the metabolic marker combination, tumor cells having high metabolic activity in the body fluid sample. Further provided is a kit used for the detecting and typing method, comprising a microwell array chip, a first metabolic marker and a second metabolic marker capable of producing fluorescence signals, and fluorescence-labeled antibodies specific to leukocyte common antigen.Type: ApplicationFiled: May 5, 2020Publication date: August 20, 2020Inventors: Qihui Shi, Yuliang Deng, Yin Tang, Zhuo Wang
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Publication number: 20180258378Abstract: Provided are a method for detecting a free rare tumor cell in a human biological fluid sample and assay kit. Specifically, the method of the invention determines the existence of an active tumor cell in a biological fluid sample of a cancer patient by detecting and confirming the existence of glucose absorption capability of a karyocyte and expression of a leukocyte marker (CD45).Type: ApplicationFiled: April 29, 2016Publication date: September 13, 2018Inventors: Qihui SHI, Shun LU, Yuliang DENG, Yin TANG
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Patent number: 9326995Abstract: The invention provides a homogeneous composition comprising a hemostatically effective amount of a charged oxide, wherein the composition has an isoelectric point, as measured in calcium chloride, below 7.3 or above 7.4. Typically, the charged oxide is selected from the group consisting of silaceous oxides, titanium oxides, aluminum oxides, calcium oxides, zinc oxides, nickel oxides and iron oxides. In some embodiments, the composition further comprises a second oxide selected from the group consisting of calcium oxide, sodium oxide, magnesium oxide, zinc oxide, phosphorus oxide and alumina. In a typical embodiment of the invention, the charged oxide is silaceous oxide, the second oxide comprises calcium oxide and the ratio, by molar ratio, of silaceous oxide to calcium oxide is 0.25 to 15. Optionally, the composition further comprises phosphorous oxide. Also described are methods of making and using such compositions.Type: GrantFiled: August 15, 2006Date of Patent: May 3, 2016Assignee: The Regents of the University of CaliforniaInventors: Galen D. Stucky, Todd A. Ostomel, Qihui Shi, April Sawvel, Sarah Baker
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Publication number: 20120037840Abstract: Methods and compositions for removing a contaminant from its environment. The method includes forming a magnetic composition comprising the contaminant and an amphiphilic substance, and applying a magnetic field to the magnetic composition so as to separate the magnetic composition from the environment. One composition includes a micelle array confined in a magnetic mesoporous framework. Another composition is formed by adhering an amphiphilic material comprising functional surface groups to a contaminant, then interacting a magnetic material with the functional surface groups of the amphiphilic material. In various versions, the contaminant can be a hydrophobic organic compound, or a fullerene-related nanoparticle. The methods can also be used to purify hydrophobic organic compounds or fullerene-related nanoparticles.Type: ApplicationFiled: February 25, 2009Publication date: February 16, 2012Inventors: Galen Stucky, Arturo A. Keller, Yifeng Shi, Peng Wang, Qihui Shi, Hongjun Liang
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Patent number: 7858123Abstract: The invention provides compositions, methods and devices relating to a silaceous oxide that generates a reduced heat of hydration upon contact with blood. By reducing the heat of hydration, the compositions provide a hemostatic agent that attenuates a tissue burning side effect of conventional hemostatic agents without adversely affecting the wound healing properties of the composition.Type: GrantFiled: April 4, 2006Date of Patent: December 28, 2010Assignee: The Regents of the University of CaliforniaInventors: Galen D. Stucky, Todd A. Ostomel, Qihui Shi, Peter K. Stoimenov, Patricia A. Holden
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Publication number: 20100209531Abstract: The invention provides a homogeneous composition comprising a hemostatically effective amount of a charged oxide, wherein the composition has an isoelectric point, as measured in calcium chloride, below 7.3 or above 7.4. Typically, the charged oxide is selected from the group consisting of silaceous oxides, titanium oxides, aluminum oxides, calcium oxides, zinc oxides, nickel oxides and iron oxides. In some embodiments, the composition further comprises a second oxide selected from the group consisting of calcium oxide, sodium oxide, magnesium oxide, zinc oxide, phosphorus oxide and alumina. In a typical embodiment of the invention, the charged oxide is silaceous oxide, the second oxide comprises calcium oxide and the ratio, by molar ratio, of silaceous oxide to calcium oxide is 0.25 to 15. Optionally, the composition further comprises phosphorous oxide. Also described are methods of making and using such compositions.Type: ApplicationFiled: August 15, 2006Publication date: August 19, 2010Applicant: The Regents of the University of CaliforniaInventors: Galen Stucky, Todd Ostomel, Qihui Shi, April Sawvel, Sarah Baker
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Publication number: 20090186013Abstract: The invention provides compositions, methods and devices relating to a silaceous oxide that generates a reduced heat of hydration upon contact with blood. By reducing the heat of hydration, the compositions provide a hemostatic agent that attenuates a tissue burning side effect of conventional hemostatic agents without adversely affecting the wound healing properties of the composition.Type: ApplicationFiled: January 12, 2009Publication date: July 23, 2009Inventors: Galen D. Stucky, Todd A. Ostomel, Qihui Shi, Peter K. Stoimenov, Patricia A. Holden
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Publication number: 20070154564Abstract: The invention provides a homogeneous composition comprising a hemostatically effective amount of a charged oxide, wherein the composition has an isoelectric point, as measured in calcium chloride, below 7.3 or above 7.4. Typically, the charged oxide is selected from the group consisting of silaceous oxides, titanium oxides, aluminum oxides, calcium oxides, zinc oxides, nickel oxides and iron oxides. In some embodiments, the composition further comprises a second oxide selected from the group consisting of calcium oxide, sodium oxide, magnesium oxide, zinc oxide, phosphorus oxide and alumina. In a typical embodiment of the invention, the charged oxide is silaceous oxide, the second oxide comprises calcium oxide and the ratio, by molar ratio, of silaceous oxide to calcium oxide is 0.25 to 15. Optionally, the composition further comprises phosphorous oxide. Also described are methods of making and using such compositions.Type: ApplicationFiled: August 15, 2006Publication date: July 5, 2007Applicant: The Regents of the University of CaliforniaInventors: Galen Stucky, Todd Ostomel, Qihui Shi
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Publication number: 20070031515Abstract: The invention provides compositions, methods and devices relating to a silaceous oxide that generates a reduced heat of hydration upon contact with blood. By reducing the heat of hydration, the compositions provide a hemostatic agent that attenuates a tissue burning side effect of conventional hemostatic agents without adversely affecting the wound healing properties of the composition.Type: ApplicationFiled: April 4, 2006Publication date: February 8, 2007Inventors: Galen Stucky, Todd Ostomel, Qihui Shi, Peter Stoimenov, Patricia Holden