Abstract: A brain-inspired cognitive learning method can obtain good learning results in various environments and tasks by selecting the most suitable algorithm models and parameters based on the environments and tasks, and can correct wrong behavior. The framework includes four main modules: a cognitive feature extraction module, a cognitive control module, a learning network module, and a memory module. The memory module includes a data base, a cognitive case base, and an algorithm and hyper-parameter base, which store data of dynamic environments and tasks, cognitive cases, and concrete algorithms and hyper-parameter values, respectively. For dynamic environments and tasks, the most suitable algorithm model and hyper-parameter combination can be flexibly selected. In addition, with “good money drives out bad”, mislabeled data is corrected using correctly labeled data, to achieve robustness of training data.

Abstract: The invention relates to the fields of biomaterials, tissue engineering and regenerative medicine. More specifically, it relates to biomaterial substrates having precise surface properties and the use thereof to investigate cell-material interactions. Provided is a cell culture system having a biomaterial substrate which has at least a first linear surface gradient oriented orthogonally to a second linear surface gradient, wherein the first gradient and the second gradient are selected from the group consisting of stiffness (S), (aligned) topography (T) and wettability (W). Also provided is a cell screening platform having a combination of at least two, preferably at least three, more preferably four distinct cell culture systems.

Abstract: The present invention relates to an immunogen for use in preventing or treating familial frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and/or amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) in patients with C9orf72 repeat expansion. The immunogen is comprising or consisting of a polypeptide consisting of dipeptide-repeats with a sequence selected from the group consisting of (Gly-Ala)a, (Gly-Pro)a, (Gly-Arg)a, (Pro-Ala)a and (Pro-Arg)a, wherein a is an integer of 4 to 25.

Abstract: A protective case for a pearl comprises a wall defining a closed internal volume for containing a pearl when the case is closed. A first case part and a second case part each form a substantial wall portion of the wall of the case. The first and second case parts are adapted to be releasably closed together to define the closed internal volume of the case, and each of the first and second case parts is formed from a transparent material. An irreversible locking mechanism is adapted to lock the first and second parts together when closed and prevent the first and second parts from being opened, such that the locking mechanism must be broken to open the case. The locking mechanism is located inside the case and is visible through the transparent material of at least one of the first and second case parts so that a state of the locking mechanism is discernible from an outside of the case.

Abstract: The invention relates to the fields of biomaterials, tissue engineering and regenerative medicine. More specifically, it relates to biomaterial substrates having precise surface properties and the use thereof to investigate cell-material interactions. Provided is a cell culture system having a biomaterial substrate which has at least a first linear surface gradient oriented orthogonally to a second linear surface gradient, wherein the first gradient and the second gradient are selected from the group consisting of stiffness (S), (aligned) topography (T) and wettability (W). Also provided is a cell screening platform having a combination of at least two, preferably at least three, more preferably four distinct cell culture systems.

Abstract: A protective case for a pearl comprises a wall defining a closed internal volume for containing a pearl when the case is closed. A first case part and a second case part each form a substantial wall portion of the wall of the case. The first and second case parts are adapted to be releasably closed together to define the closed internal volume of the case, and each of the first and second case parts is formed from a transparent material. An irreversible locking mechanism is adapted to lock the first and second parts together when closed and prevent the first and second parts from being opened, such that the locking mechanism must be broken to open the case. The locking mechanism is located inside the case and is visible through the transparent material of at least one of the first and second case parts so that a state of the locking mechanism is discernible from an outside of the case.